PMID- 30237582
OWN - NLM
STAT- MEDLINE
DCOM- 20200207
LR  - 20221207
IS  - 1473-1150 (Electronic)
IS  - 1470-269X (Linking)
VI  - 19
IP  - 3
DP  - 2019 Jun
TI  - HLA-C*12:02 is strongly associated with Xuesaitong-induced cutaneous adverse drug 
      reactions.
PG  - 277-285
LID - 10.1038/s41397-018-0051-3 [doi]
AB  - Xuesaitong (XST) is mainly used to treat cardiovascular and cerebrovascular 
      diseases, sometimes causing cutaneous adverse drug reactions (cADRs) with unknown 
      mechanisms of pathogenicity or risk factors. We aimed to verify whether human 
      leukocyte antigen (HLA) alleles are associated with XST-related cADRs in Han 
      Chinese population. We carried out an association study including 12 subjects 
      with XST-induced cADRs, 283 controls, and 28 XST-tolerant subjects. Five out of 
      12 patients with XST-induced cADRs carried HLA-C*12:02, and all of them received 
      XST via intravenous drip. The carrier frequency of HLA-C*12:02 was significantly 
      high compare to that of the control population (Pc = 4.4 x 10(-4), odds ratio 
      (OR) = 21.75, 95% CI = 5.78-81.88). Compared with that of the XST-tolerant group, 
      the patients who received XST through intravenous drip presented a higher OR of 
      cADRs (Pc = 0.011, OR = 27.00, 95% CI = 2.58-282.98). The results suggest that 
      HLA-C*12:02 is a potentially predictive marker of XST-induced cADRs in Han 
      Chinese, especially when XST is administered via intravenous drip.
FAU - Yan, Sijia
AU  - Yan S
AD  - Children's Hospital & Institutes of Biomedical Sciences, Fudan University, 
      Shanghai, 200032, China.
FAU - Xiong, Hao
AU  - Xiong H
AD  - Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, 
      China.
FAU - Shao, Fengmin
AU  - Shao F
AD  - Department of Nephrology, Henan Provincial People's Hospital (Zhengzhou 
      University People's Hospital), Zhengzhou, Henan, 450003, China.
FAU - Zhang, Wen
AU  - Zhang W
AD  - Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
FAU - Yang, Fanping
AU  - Yang F
AD  - Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, 
      China.
FAU - Qi, Zheng
AU  - Qi Z
AD  - Children's Hospital & Institutes of Biomedical Sciences, Fudan University, 
      Shanghai, 200032, China.
FAU - Chen, Shengan
AU  - Chen S
AD  - Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, 
      China.
FAU - He, Lin
AU  - He L
AD  - Children's Hospital & Institutes of Biomedical Sciences, Fudan University, 
      Shanghai, 200032, China.
AD  - Bio-X Institutes, Key Laboratory for the Genetics of Developmental and 
      Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong 
      University, Shanghai, 200030, China.
FAU - Jiang, Menglin
AU  - Jiang M
AD  - Children's Hospital & Institutes of Biomedical Sciences, Fudan University, 
      Shanghai, 200032, China.
FAU - Su, Yu
AU  - Su Y
AD  - Children's Hospital & Institutes of Biomedical Sciences, Fudan University, 
      Shanghai, 200032, China.
FAU - Zhu, Huizhong
AU  - Zhu H
AD  - Children's Hospital & Institutes of Biomedical Sciences, Fudan University, 
      Shanghai, 200032, China.
FAU - Qin, Shengying
AU  - Qin S
AD  - Children's Hospital & Institutes of Biomedical Sciences, Fudan University, 
      Shanghai, 200032, China.
AD  - Bio-X Institutes, Key Laboratory for the Genetics of Developmental and 
      Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong 
      University, Shanghai, 200030, China.
FAU - Zhu, Qinyuan
AU  - Zhu Q
AD  - Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, 
      China.
FAU - Luo, Xiaoqun
AU  - Luo X
AD  - Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, 
      China. luoxiaoqun913@126.com.
FAU - Xing, Qinghe
AU  - Xing Q
AD  - Children's Hospital & Institutes of Biomedical Sciences, Fudan University, 
      Shanghai, 200032, China. xingqinghe@hotmail.com.
LA  - eng
GR  - 4R00LM009826-03/LM/NLM NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20180920
PL  - United States
TA  - Pharmacogenomics J
JT  - The pharmacogenomics journal
JID - 101083949
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Saponins)
RN  - 0 (xuesetong)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Asian People/genetics
MH  - Drug Eruptions/*genetics
MH  - Drug-Related Side Effects and Adverse Reactions/*genetics
MH  - Drugs, Chinese Herbal/*adverse effects
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - HLA-C Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Saponins/*adverse effects
MH  - Young Adult
EDAT- 2018/09/22 06:00
MHDA- 2020/02/08 06:00
CRDT- 2018/09/22 06:00
PHST- 2018/01/19 00:00 [received]
PHST- 2018/08/10 00:00 [accepted]
PHST- 2018/07/19 00:00 [revised]
PHST- 2018/09/22 06:00 [pubmed]
PHST- 2020/02/08 06:00 [medline]
PHST- 2018/09/22 06:00 [entrez]
AID - 10.1038/s41397-018-0051-3 [pii]
AID - 10.1038/s41397-018-0051-3 [doi]
PST - ppublish
SO  - Pharmacogenomics J. 2019 Jun;19(3):277-285. doi: 10.1038/s41397-018-0051-3. Epub 
      2018 Sep 20.