PMID- 30237900
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 2056-5909 (Print)
IS  - 2056-5909 (Electronic)
IS  - 2056-5909 (Linking)
VI  - 24
DP  - 2018
TI  - Apolipoprotein A1 mimetic peptide ATI-5261 reverses arterial stiffness at late 
      pregnancy and early postpartum in a COMT(-/-) mouse model of preeclampsia.
PG  - 11
LID - 10.1186/s40885-018-0097-1 [doi]
LID - 11
AB  - BACKGROUND: Preeclampsia (PE) is a serious maternal complication during 
      pregnancy. Associated arterial stiffness in PE patients leads to increased risks 
      of cardiovascular diseases later in life. Cholesterol efflux capacity, especially 
      ATP binding cassette transporter A1 (ABCA1) dependent capacity, has been proposed 
      to be a likely mediator of arterial stiffness. In the present study, we aimed to 
      evaluate the effect of an apolipoprotein A1 mimetic peptide ATI-5261 on arterial 
      stiffness in a mouse model of PE. METHODS: Pregnant COMT(-/-) mice were 
      randomized to receive vehicle or ATI-5261 (30 mg/kg per day) via subcutaneous 
      injection from gestational days (GD) 10.5 to GD 18.5 or to 10 days postpartum. 
      Pregnant C57BL/6 J mice received vehicle during paralleled periods were served as 
      normal controls. RESULTS: COMT(-/-) mice displayed maternal hypertension and 
      proteinuria during pregnancy. Carotid-femoral pulse wave velocity (PWV) was 
      increased at GD 18.5 and 10 days postpartum. ATI-5261 treatment in COMT(-/-) mice 
      significantly reduced PWV and partially normalized impaired ex vivo vascular 
      function at late pregnancy and early postpartum. ATI-5261 treatment also 
      increased serum ABCA1 concentrations and cholesterol efflux capacity, as well as 
      ABCA1 expressions in the placenta. Pup weights, crown to rump lengths and 
      abdominal circumferences were reduced in COMT(-/-) mice. Treatment with ATI-5261 
      did not alter these fetal measurements but significantly reduced placental 
      weights and increased fetal to placental ratios in COMT(-/-) mice. CONCLUSION: 
      ATI-5261 reversed arterial stiffness at late pregnancy and early postpartum in a 
      COMT(-/-) mouse model of PE and may be a potential therapy for arterial stiffness 
      associated with PE.
FAU - Liao, Shutan
AU  - Liao S
AD  - 1Rural Clinical School, University of New South Wales, Sydney, NSW Australia. 
      ISNI: 0000 0004 4902 0432. GRID: grid.1005.4
AD  - 2The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. GRID: 
      grid.412615.5
FAU - Wu, Hao
AU  - Wu H
AD  - 3Chashan Teaching Centre, Department of Physiology, Wenzhou Medical University, 
      Wenzhou, 325035 Zhejiang China. ISNI: 0000 0001 0348 3990. GRID: grid.268099.c
FAU - Chen, Ruiying
AU  - Chen R
AUID- ORCID: 0000-0002-7176-6500
AD  - 3Chashan Teaching Centre, Department of Physiology, Wenzhou Medical University, 
      Wenzhou, 325035 Zhejiang China. ISNI: 0000 0001 0348 3990. GRID: grid.268099.c
LA  - eng
PT  - Journal Article
DEP - 20180915
PL  - England
TA  - Clin Hypertens
JT  - Clinical hypertension
JID - 101669508
PMC - PMC6138905
OTO - NOTNLM
OT  - Apolipoprotein A1
OT  - Arterial stiffness
OT  - Cholesterol efflux
OT  - Mice
OT  - Preeclampsia
OT  - Pulse wave velocity
COIS- This study was performed in accordance to the Guide for the Care and Use of 
      Laboratory Animals published by the US NIH. All protocols were approved by the 
      Animal Ethics Committee of Wenzhou Medical University (WZU38479-567).Not 
      applicable.The authors declare that they have no competing interests.Springer 
      Nature remains neutral with regard to jurisdictional claims in published maps and 
      institutional affiliations.
EDAT- 2018/09/22 06:00
MHDA- 2018/09/22 06:01
PMCR- 2018/09/15
CRDT- 2018/09/22 06:00
PHST- 2018/06/27 00:00 [received]
PHST- 2018/08/09 00:00 [accepted]
PHST- 2018/09/22 06:00 [entrez]
PHST- 2018/09/22 06:00 [pubmed]
PHST- 2018/09/22 06:01 [medline]
PHST- 2018/09/15 00:00 [pmc-release]
AID - 97 [pii]
AID - 10.1186/s40885-018-0097-1 [doi]
PST - epublish
SO  - Clin Hypertens. 2018 Sep 15;24:11. doi: 10.1186/s40885-018-0097-1. eCollection 
      2018.