PMID- 30239833
OWN - NLM
STAT- MEDLINE
DCOM- 20191112
LR  - 20230111
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 219
IP  - 4
DP  - 2019 Jan 29
TI  - Plasmodium falciparum Activates CD16+ Dendritic Cells to Produce Tumor Necrosis 
      Factor and Interleukin-10 in Subpatent Malaria.
PG  - 660-671
LID - 10.1093/infdis/jiy555 [doi]
AB  - BACKGROUND: The malaria causing parasite Plasmodium subverts host immune 
      responses by several strategies including the modulation of dendritic cells 
      (DCs). METHODS: In this study, we show that Plasmodium falciparum skewed CD16+ DC 
      cytokine responses towards interleukin (IL)-10 production in vitro, distinct to 
      the cytokine profile induced by Toll-like receptor ligation. To determine CD16+ 
      DC responsiveness in vivo, we assessed their function after induced P falciparum 
      infection in malaria-naive volunteers. RESULTS: CD16+ DCs underwent distinctive 
      activation, with increased expression of maturation markers human leukocyte 
      antigen (HLA)-DR and CD86, enhanced tumor necrosis factor (TNF) production, and 
      coproduction of TNF/IL-10. In vitro restimulation with P falciparum further 
      increased IL-10 production. In contrast, during naturally acquired malaria 
      episode, CD16+ DCs showed diminished maturation, suggesting increased parasite 
      burden and previous exposure influence DC subset function. CONCLUSIONS: These 
      findings identify CD16+ DCs as the only DC subset activated during primary 
      blood-stage human Plasmodium infection. As dual cytokine producers, CD16+ DCs 
      contribute to inflammatory as well as regulatory innate immune processes.
FAU - Loughland, Jessica R
AU  - Loughland JR
AD  - Menzies School of Health Research and Charles Darwin University, Darwin, 
      Australia.
FAU - Woodberry, Tonia
AU  - Woodberry T
AD  - Menzies School of Health Research and Charles Darwin University, Darwin, 
      Australia.
FAU - Boyle, Michelle J
AU  - Boyle MJ
AD  - Menzies School of Health Research and Charles Darwin University, Darwin, 
      Australia.
AD  - Burnet Institute, Melbourne, Victoria, Australia.
FAU - Tipping, Peta E
AU  - Tipping PE
AD  - Menzies School of Health Research and Charles Darwin University, Darwin, 
      Australia.
FAU - Piera, Kim A
AU  - Piera KA
AD  - Menzies School of Health Research and Charles Darwin University, Darwin, 
      Australia.
FAU - Amante, Fiona H
AU  - Amante FH
AD  - QIMR Berghofer Medical Research Institute, Brisbane, Australia.
FAU - Kenangalem, Enny
AU  - Kenangalem E
AD  - Timika Malaria Research Program, Papuan Health and Community Development 
      Foundation, Indonesia.
AD  - District Health Authority, Timika, Papua, Indonesia.
FAU - Price, Ric N
AU  - Price RN
AD  - Menzies School of Health Research and Charles Darwin University, Darwin, 
      Australia.
AD  - Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United 
      Kingdom.
FAU - Engwerda, Christian R
AU  - Engwerda CR
AD  - QIMR Berghofer Medical Research Institute, Brisbane, Australia.
FAU - Anstey, Nicholas M
AU  - Anstey NM
AD  - Menzies School of Health Research and Charles Darwin University, Darwin, 
      Australia.
FAU - McCarthy, James S
AU  - McCarthy JS
AD  - QIMR Berghofer Medical Research Institute, Brisbane, Australia.
FAU - Minigo, Gabriela
AU  - Minigo G
AD  - Menzies School of Health Research and Charles Darwin University, Darwin, 
      Australia.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 200909/WT_/Wellcome Trust/United Kingdom
GR  - 200909/Z/16/Z/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (FCGR3B protein, human)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (IL10 protein, human)
RN  - 0 (Receptors, IgG)
RN  - 0 (TNF protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - Child
MH  - Dendritic Cells/chemistry/*immunology
MH  - Female
MH  - GPI-Linked Proteins/analysis
MH  - Humans
MH  - Interleukin-10/*metabolism
MH  - Malaria, Falciparum
MH  - Male
MH  - Plasmodium falciparum/*immunology
MH  - Receptors, IgG/analysis
MH  - Tumor Necrosis Factor-alpha/*metabolism
MH  - Young Adult
PMC - PMC6339523
MID - EMS79960
EDAT- 2018/09/22 06:00
MHDA- 2019/11/13 06:00
PMCR- 2018/10/15
CRDT- 2018/09/22 06:00
PHST- 2018/06/06 00:00 [received]
PHST- 2018/09/25 00:00 [accepted]
PHST- 2018/09/22 06:00 [pubmed]
PHST- 2019/11/13 06:00 [medline]
PHST- 2018/09/22 06:00 [entrez]
PHST- 2018/10/15 00:00 [pmc-release]
AID - 5098450 [pii]
AID - jiy555 [pii]
AID - 10.1093/infdis/jiy555 [doi]
PST - ppublish
SO  - J Infect Dis. 2019 Jan 29;219(4):660-671. doi: 10.1093/infdis/jiy555.