PMID- 30240124
OWN - NLM
STAT- MEDLINE
DCOM- 20191104
LR  - 20191104
IS  - 1365-2982 (Electronic)
IS  - 1350-1925 (Linking)
VI  - 30
IP  - 12
DP  - 2018 Dec
TI  - Serum cholinesterase activity is elevated in female diarrhea-predominant 
      irritable bowel syndrome patients compared to matched controls.
PG  - e13464
LID - 10.1111/nmo.13464 [doi]
AB  - BACKGROUND: Micro-inflammation is involved in the pathogenesis of irritable bowel 
      syndrome (IBS). The parasympathetic nervous system, via acetylcholine (ACh), and 
      its hydrolytic enzymes, plays a role in regulating inflammation. Increased serum 
      cholinesterase activity, named cholinergic Status (CS), is associated with 
      decreased inflammatory inhibition (ie, pro-inflammation). We assessed the 
      association between IBS diarrhea-predominant (IBS-D) symptoms, CS, and 
      inflammatory biomarkers. METHODS: Women with IBS-D were prospectively recruited. 
      Serum acetylcholinesterase (AChE), CS, and high-sensitivity C-reactive protein 
      (hs-CRP) levels were analyzed and fecal calprotectin (FC) in a subgroup of 
      patients. The control group included women attending routine health checkups 
      (matched by age and BMI). KEY RESULTS: Ninety-four women with IBS-D were compared 
      to matched controls (1:1). Serum CS, AChE, and the AChE/butyrylcholinesterase 
      (BChE) ratios were significantly increased in the IBS-D group compared to matched 
      controls (P = 0.018, P = 0.001, and P = 0.004, respectively). Using a multiple 
      logistic regression model, IBS-D was almost twice as likely in women with high CS 
      compared to women with low CS (adjusted OR=1.84 (95% CI: 1.01-3.33), P = 0.045). 
      Furthermore, IBS-D patients with higher hs-CRP levels demonstrated lower CS and 
      BChE activity and elevated AChE and AChE/BChE ratios compared to patients with 
      lower hs-CRP levels (P = 0.026, P = 0.036, P = 0.002; and P = 0.0007, 
      respectively). CS was not correlated with the IBS symptoms score. CONCLUSIONS AND 
      INFERENCES: This is the first study to explore the potential role of serum CS in 
      IBS-D. The findings emphasize the possible role of the autonomic nervous system 
      and its anti-inflammatory properties in IBS.
CI  - (c) 2018 John Wiley & Sons Ltd.
FAU - Hod, Keren
AU  - Hod K
AUID- ORCID: 0000-0002-8115-7274
AD  - Department of Epidemiology and Preventive Medicine, School of Public Health, 
      Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
AD  - Research Division, Epidemiology Service, Assuta Medical Centers, Tel Aviv, 
      Israel.
FAU - Sperber, Ami D
AU  - Sperber AD
AD  - Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 
      Israel.
FAU - Maharshak, Nitsan
AU  - Maharshak N
AD  - Department of Gastroenterology and Liver Diseases, Tel-Aviv Sourasky Medical 
      Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv, Israel.
FAU - Ron, Yishay
AU  - Ron Y
AD  - Department of Gastroenterology and Liver Diseases, Tel-Aviv Sourasky Medical 
      Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv, Israel.
FAU - Shapira, Izthak
AU  - Shapira I
AD  - Internal Medicine "C", "D" and "E", the Tel Aviv Sourasky Medical Center, 
      affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, 
      Israel.
FAU - David, Zeltser
AU  - David Z
AD  - Internal Medicine "C", "D" and "E", the Tel Aviv Sourasky Medical Center, 
      affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, 
      Israel.
FAU - Rogowski, Ori
AU  - Rogowski O
AD  - Internal Medicine "C", "D" and "E", the Tel Aviv Sourasky Medical Center, 
      affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, 
      Israel.
FAU - Berliner, Shlomo
AU  - Berliner S
AD  - Internal Medicine "C", "D" and "E", the Tel Aviv Sourasky Medical Center, 
      affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, 
      Israel.
FAU - Shenhar-Tsarfaty, Shani
AU  - Shenhar-Tsarfaty S
AD  - Internal Medicine "C", "D" and "E", the Tel Aviv Sourasky Medical Center, 
      affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, 
      Israel.
FAU - Dekel, Roy
AU  - Dekel R
AD  - Department of Gastroenterology and Liver Diseases, Tel-Aviv Sourasky Medical 
      Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv, Israel.
LA  - eng
PT  - Journal Article
DEP - 20180921
PL  - England
TA  - Neurogastroenterol Motil
JT  - Neurogastroenterology and motility
JID - 9432572
RN  - 0 (Biomarkers)
RN  - EC 3.1.1.8 (Cholinesterases)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers/*blood
MH  - Case-Control Studies
MH  - Cholinesterases/*blood
MH  - Diarrhea/blood/enzymology/etiology
MH  - Female
MH  - Humans
MH  - Inflammation/blood/etiology
MH  - Irritable Bowel Syndrome/blood/complications/*enzymology
MH  - Middle Aged
MH  - Young Adult
OTO - NOTNLM
OT  - acetylcholinesterase
OT  - cholinergic status
OT  - irritable bowel syndrome
EDAT- 2018/09/22 06:00
MHDA- 2019/11/05 06:00
CRDT- 2018/09/22 06:00
PHST- 2018/05/23 00:00 [received]
PHST- 2018/08/09 00:00 [revised]
PHST- 2018/08/13 00:00 [accepted]
PHST- 2018/09/22 06:00 [pubmed]
PHST- 2019/11/05 06:00 [medline]
PHST- 2018/09/22 06:00 [entrez]
AID - 10.1111/nmo.13464 [doi]
PST - ppublish
SO  - Neurogastroenterol Motil. 2018 Dec;30(12):e13464. doi: 10.1111/nmo.13464. Epub 
      2018 Sep 21.