PMID- 30240448
OWN - NLM
STAT- MEDLINE
DCOM- 20190304
LR  - 20190304
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 9
DP  - 2018
TI  - Circulating monocyte subsets and heart failure prognosis.
PG  - e0204074
LID - 10.1371/journal.pone.0204074 [doi]
LID - e0204074
AB  - Monocytes are a heterogeneous population of effector cells with key roles in 
      tissue integrity restoration and maintenance. Here, we explore the association of 
      monocyte subsets and prognosis in patients with ambulatory heart failure (HF). 
      Monocyte subsets were classified as classical (CD14++/CD16-), intermediate 
      (CD14++/CD16+), or non-classical (CD14+/CD16++). Percentage distribution and 
      absolute cell count were assessed in each subset, and multivariable Cox 
      regression analyses were performed with all-cause death, HF-related 
      hospitalization, and the composite end-point of both as dependent variables. 400 
      patients were consecutively included (72.8% male, age 69.4+/-12.2 years, 45.5% from 
      ischemic aetiology, left ventricle ejection fraction (LVEF) 41.6% +/-14.5, New York 
      Heart Association (NYHA) class II 62.8% and III 30.8%). During a mean follow-up 
      of 2.6+/-0.9 years, 107 patients died, 99 had a HF-related hospitalization and 160 
      suffered the composite end-point of all-cause death or HF-related 
      hospitalization. Monocyte subsets assessed in percentages were not independently 
      associated to any of the end-points. When considering number of cells/muL, 
      intermediate subset was independently associated with an increase of all-cause 
      death (HR 1.25 [95% CI 1,02-1.52], p = 0.03), and the composite end-point HR 1.20 
      [95% CI 1,03-1.40], p = 0.02). The presented findings show that absolute cell 
      count of monocyte subsets was preferred over monocyte percentage for prognosis 
      stratification for outpatients with HF. The intermediate monocyte subset provides 
      information on increased risk of all-cause death and the composite end-point.
FAU - Elchinova, Elena
AU  - Elchinova E
AD  - Heart Failure Unit and Cardiology Service, Germans Trias i Pujol University 
      Hospital, Badalona, Spain.
AD  - Department of Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain.
AD  - Inselspital, University Hospital, Bern, Switzerland.
FAU - Teubel, Iris
AU  - Teubel I
AD  - Flow Cytometry Facility, Germans Trias i Pujol Health Science Research Institute, 
      Badalona, Spain.
FAU - Roura, Santiago
AU  - Roura S
AUID- ORCID: 0000-0003-4063-9661
AD  - CIBERCV, Instituto de Salud Carlos III, Madrid, Spain.
AD  - ICREC Research Program, Germans Trias i Pujol Health Science Research Institute, 
      Badalona, Spain.
FAU - Fernandez, Marco A
AU  - Fernandez MA
AD  - Flow Cytometry Facility, Germans Trias i Pujol Health Science Research Institute, 
      Badalona, Spain.
FAU - Lupon, Josep
AU  - Lupon J
AD  - Heart Failure Unit and Cardiology Service, Germans Trias i Pujol University 
      Hospital, Badalona, Spain.
AD  - Department of Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain.
AD  - CIBERCV, Instituto de Salud Carlos III, Madrid, Spain.
FAU - Galvez-Monton, Carolina
AU  - Galvez-Monton C
AD  - CIBERCV, Instituto de Salud Carlos III, Madrid, Spain.
AD  - ICREC Research Program, Germans Trias i Pujol Health Science Research Institute, 
      Badalona, Spain.
FAU - de Antonio, Marta
AU  - de Antonio M
AD  - Heart Failure Unit and Cardiology Service, Germans Trias i Pujol University 
      Hospital, Badalona, Spain.
AD  - CIBERCV, Instituto de Salud Carlos III, Madrid, Spain.
FAU - Moliner, Pedro
AU  - Moliner P
AD  - Heart Failure Unit and Cardiology Service, Germans Trias i Pujol University 
      Hospital, Badalona, Spain.
FAU - Domingo, Mar
AU  - Domingo M
AUID- ORCID: 0000-0002-2935-1272
AD  - Heart Failure Unit and Cardiology Service, Germans Trias i Pujol University 
      Hospital, Badalona, Spain.
FAU - Zamora, Elisabet
AU  - Zamora E
AD  - Heart Failure Unit and Cardiology Service, Germans Trias i Pujol University 
      Hospital, Badalona, Spain.
AD  - Department of Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain.
AD  - CIBERCV, Instituto de Salud Carlos III, Madrid, Spain.
FAU - Nunez, Julio
AU  - Nunez J
AD  - CIBERCV, Instituto de Salud Carlos III, Madrid, Spain.
AD  - Cardiology Department, Hospital Clinico Universitario, INCLIVA, Universitat de 
      Valencia, Valencia, Spain.
FAU - Cediel, German
AU  - Cediel G
AUID- ORCID: 0000-0001-9667-7507
AD  - Heart Failure Unit and Cardiology Service, Germans Trias i Pujol University 
      Hospital, Badalona, Spain.
FAU - Bayes-Genis, Antoni
AU  - Bayes-Genis A
AD  - Heart Failure Unit and Cardiology Service, Germans Trias i Pujol University 
      Hospital, Badalona, Spain.
AD  - Department of Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain.
AD  - CIBERCV, Instituto de Salud Carlos III, Madrid, Spain.
AD  - ICREC Research Program, Germans Trias i Pujol Health Science Research Institute, 
      Badalona, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180921
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Aged
MH  - Cause of Death
MH  - *Cell Movement
MH  - Disease-Free Survival
MH  - Female
MH  - Heart Failure/blood/*diagnosis/*pathology
MH  - Humans
MH  - Male
MH  - Monocytes/*pathology
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Risk Factors
PMC - PMC6150659
COIS- The authors have declared that no competing interests exist.
EDAT- 2018/09/22 06:00
MHDA- 2019/03/05 06:00
PMCR- 2018/09/21
CRDT- 2018/09/22 06:00
PHST- 2018/06/04 00:00 [received]
PHST- 2018/08/31 00:00 [accepted]
PHST- 2018/09/22 06:00 [entrez]
PHST- 2018/09/22 06:00 [pubmed]
PHST- 2019/03/05 06:00 [medline]
PHST- 2018/09/21 00:00 [pmc-release]
AID - PONE-D-18-16686 [pii]
AID - 10.1371/journal.pone.0204074 [doi]
PST - epublish
SO  - PLoS One. 2018 Sep 21;13(9):e0204074. doi: 10.1371/journal.pone.0204074. 
      eCollection 2018.