PMID- 30241508
OWN - NLM
STAT- MEDLINE
DCOM- 20190910
LR  - 20240331
IS  - 1471-2369 (Electronic)
IS  - 1471-2369 (Linking)
VI  - 19
IP  - 1
DP  - 2018 Sep 21
TI  - Urinary epidermal growth factor, monocyte chemoattractant protein-1 or their 
      ratio as predictors for rapid loss of renal function in type 2 diabetic patients 
      with diabetic kidney disease.
PG  - 246
LID - 10.1186/s12882-018-1043-x [doi]
LID - 246
AB  - BACKGROUND: Increased monocyte chemoattractant protein-1 (MCP-1) and decreased 
      epidermal growth factor (EGF) are promising biomarkers to predict progressive 
      decline in kidney function in non-diabetic kidney diseases. We aimed to evaluate 
      the performance of urinary EGF, MCP-1 or their ratio in predicting rapid decline 
      of GFR in a cohort of Type 2 diabetic patients (T2DM) with diabetic kidney 
      disease (DKD). METHODS: T2DM patients (n = 83) with DKD at high risk for renal 
      progression were followed up prospectively. The baseline urine values of MCP-1 to 
      creatinine ratio (UMCP-1), EGF to creatinine ratio (UEGF), EGF to MCP-1 ratio 
      (UEGF/MCP-1) and albumin to creatinine ratio (UACR) were measured. The primary 
      outcome was a decline in estimated glomerular filtration rate (GFR) of >/=25% 
      yearly from baseline. RESULTS: During follow-up time of 23 months, patients with 
      rapid decline in estimated GFR of >/=25% yearly from baseline had significantly 
      higher baseline levels of UMCP-1, and UACR and lower UEGF and UEGF/MCP-1 ratio. 
      All renal biomarkers predicted primary outcomes with ROC (95%CI) for UMCP-1=0.73 
      (0.62-0.84), UEGF=0.68 (0.57-0.80), UEGF/MCP-1=0.74 (0.63-0.85), and UACR =0.84 
      (0.75-0.93). By univariate analysis, blood pressure, GFR, UACR, UMCP-1, UEGF, and 
      UEGF/MCP-1 were associated with rapid decline GFR. By multivariate analysis, 
      UACR, systolic blood pressure, and UMCP-1 or UEGF/MCP-1 were independently 
      associated with rapid GFR decline. CONCLUSIONS: UMCP-1 or UEGF/MCP-1 ratio were 
      associated with rapid renal progression independent from conventional risk 
      factors in DKD.
FAU - Satirapoj, Bancha
AU  - Satirapoj B
AD  - Division of Nephrology, Department of Medicine, Phramongkutklao Hospital and 
      College of Medicine, Bangkok, Thailand.
FAU - Dispan, Rattanawan
AU  - Dispan R
AD  - Division of Nephrology, Department of Medicine, Phramongkutklao Hospital and 
      College of Medicine, Bangkok, Thailand.
FAU - Radinahamed, Piyanuch
AU  - Radinahamed P
AD  - Division of Nephrology, Department of Medicine, Faculty of Medicine Ramathibodi 
      Hospital, Mahidol University, 270 Rama 6 Rd, Bangkok, 10400, Thailand.
FAU - Kitiyakara, Chagriya
AU  - Kitiyakara C
AUID- ORCID: 0000-0001-6340-3534
AD  - Division of Nephrology, Department of Medicine, Faculty of Medicine Ramathibodi 
      Hospital, Mahidol University, 270 Rama 6 Rd, Bangkok, 10400, Thailand. 
      kitiyakc@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180921
PL  - England
TA  - BMC Nephrol
JT  - BMC nephrology
JID - 100967793
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Aged
MH  - Albuminuria/urine
MH  - Biomarkers/urine
MH  - Cardiovascular Diseases
MH  - Chemokine CCL2/*urine
MH  - Creatinine/urine
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Angiopathies
MH  - Diabetic Nephropathies/*diagnosis/physiopathology/urine
MH  - Disease Progression
MH  - Epidermal Growth Factor/*urine
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Factors
PMC - PMC6150979
OTO - NOTNLM
OT  - Biomarker
OT  - Diabetic nephropathy
OT  - Epidermal growth factor (EGF); kidney; cytokine
OT  - Monocyte chemoattractant protein-1 (MCP-1)
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: The study was conducted according to 
      the Declaration of Helsinki, and approved by the Ethics Committee of the Faculty 
      of Medicine, Ramathibodi Hospital and the Royal Thai Army Medical Department. All 
      the subjects gave written informed consent. CONSENT FOR PUBLICATION: Not 
      applicable. COMPETING INTERESTS: The authors declare that they have no competing 
      interests. PUBLISHER'S NOTE: Springer Nature remains neutral with regard to 
      jurisdictional claims in published maps and institutional affiliations.
EDAT- 2018/09/23 06:00
MHDA- 2019/09/11 06:00
PMCR- 2018/09/21
CRDT- 2018/09/23 06:00
PHST- 2018/04/17 00:00 [received]
PHST- 2018/09/11 00:00 [accepted]
PHST- 2018/09/23 06:00 [entrez]
PHST- 2018/09/23 06:00 [pubmed]
PHST- 2019/09/11 06:00 [medline]
PHST- 2018/09/21 00:00 [pmc-release]
AID - 10.1186/s12882-018-1043-x [pii]
AID - 1043 [pii]
AID - 10.1186/s12882-018-1043-x [doi]
PST - epublish
SO  - BMC Nephrol. 2018 Sep 21;19(1):246. doi: 10.1186/s12882-018-1043-x.