PMID- 30242298
OWN - NLM
STAT- MEDLINE
DCOM- 20190111
LR  - 20200825
IS  - 2972-4066 (Electronic)
IS  - 0304-4602 (Linking)
VI  - 47
IP  - 8
DP  - 2018 Aug
TI  - Performance of the Paediatric Index of Mortality 3 and Paediatric Logistic Organ 
      Dysfunction 2 Scores in Critically Ill Children.
PG  - 285-290
AB  - INTRODUCTION: The Paediatric Index of  Mortality 3 (PIM 3) and Paediatric 
      Logistic Organ Dysfunction 2 (PELOD 2) scores were recently revised. We aimed to 
      assess the performance of these scores in a contemporary cohort of critically ill 
      children. MATERIALS AND METHODS: This is a single-centre prospective study 
      conducted in a multidisciplinary paediatric intensive care unit (PICU). 
      Consecutive PICU admissions over 1 year were included and admission PIM 3 and 
      PELOD 2 scores were calculated. The performance of each of the scores was 
      evaluated by calculating the area under the curve (AUC) of the receiver operating 
      characteristic (ROC) and the Hosmer-Lemeshow goodness-of-fit test for the outcome 
      of PICU mortality. RESULTS: A total of  570 patient admissions were eligible for 
      this study. The median age of patients was 3.1 (interquartile range [IQR]: 0.4, 
      8.9 years). Overall median PIM 3 and PELOD 2 scores were 1.2 (IQR: 0.4, 3.2) % 
      and 4 (IQR: 2, 7), respectively. The overall mortality rate was 35/570 (6.1%). 
      The PIM 3 and PELOD 2 scores had good discrimination for mortality (AUCs 0.88 
      [95% confidence interval (CI) 0.85, 0.91] and 0.86 [95% CI 0.83, 0.89], 
      respectively). Goodness-of-fit was satisfactory for both scores. Higher PIM 3 and 
      PELOD 2 scores were also associated with decreasing ventilator and PICU-free 
      days. CONCLUSION: PIM 3 and PELOD 2 scores are robust severity of illness scores 
      that are generalisable to a contemporary cohort of critically ill children in 
      Singapore.
FAU - Wong, Judith Jm
AU  - Wong JJ
AD  - Children's Intensive Care Unit, Department of Paediatric Subspecialities, KK 
      Women's and Children's Hospital, Singapore.
FAU - Hornik, Christoph P
AU  - Hornik CP
FAU - Mok, Yee Hui
AU  - Mok YH
FAU - Loh, Tsee Foong
AU  - Loh TF
FAU - Lee, Jan Hau
AU  - Lee JH
LA  - eng
PT  - Journal Article
PL  - Singapore
TA  - Ann Acad Med Singap
JT  - Annals of the Academy of Medicine, Singapore
JID - 7503289
SB  - IM
MH  - Area Under Curve
MH  - Child
MH  - Child, Preschool
MH  - Critical Illness/*mortality
MH  - Hospital Mortality/*trends
MH  - Humans
MH  - *Intensive Care Units, Pediatric
MH  - Multiple Organ Failure/*mortality
MH  - Prospective Studies
MH  - ROC Curve
MH  - Singapore
EDAT- 2018/09/23 06:00
MHDA- 2019/01/12 06:00
CRDT- 2018/09/23 06:00
PHST- 2018/09/23 06:00 [entrez]
PHST- 2018/09/23 06:00 [pubmed]
PHST- 2019/01/12 06:00 [medline]
PST - ppublish
SO  - Ann Acad Med Singap. 2018 Aug;47(8):285-290.