PMID- 30243184
OWN - NLM
STAT- MEDLINE
DCOM- 20190403
LR  - 20191201
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Print)
IS  - 0160-4120 (Linking)
VI  - 121
IP  - Pt 1
DP  - 2018 Dec
TI  - Temporal trends in serum polybrominated diphenyl ether concentrations in the 
      Australian population, 2002-2013.
PG  - 357-364
LID - S0160-4120(18)31172-3 [pii]
LID - 10.1016/j.envint.2018.09.014 [doi]
AB  - In Australia, systematic biomonitoring of persistent organic pollutants (POPs) in 
      pooled serum samples stratified by age and sex has occurred every two years 
      between 2002/03 and 2012/13. Multiple regression modeling on log10-transformed 
      serum pool concentrations of BDEs 47, 99, 100 and 153 and on the sum of these 
      (Sigma(4)PBDE) was conducted to examine trends by sex and time since baseline, 
      stratified by age group. Temporal trends were age- and congener-specific, with 
      the largest changes per year of observation in the 0-4 year old group, with beta 
      (SE) = -0.098 (0.013) for log(10)BDE47; -0.119 (0.012) for log(10)BDE99; -0.084 
      (0.014) for log(10)BDE100, and -0.053 (0.013) for log(10)BDE153, all p < 0.001. 
      Adults over age 16 showed much smaller decreasing temporal trends for BDE47 and 
      BDE99, no significant changes in BDE100, and, for the oldest age groups, slight 
      increases in BDE153. As a result, Sigma(4)PBDE concentrations were stable over the 
      entire time period in adults older than 16. Concentrations of each BDE in pools 
      from females aged 31-60 were significantly lower compared to males. Relative 
      proportions of BDE47 declined, while BDE153 accounted for a greater share of 
      Sigma(4)PBDE over time. Whereas previously we saw a large elevation in the youngest 
      age groups compared to older children and adults, this is no longer the case. 
      This may be due to a decline in infant and toddler exposures in the indoor 
      environment as use of PBDEs in consumer products has been phased out, suggesting 
      temporal changes in the relative sources of exposure for young children in 
      Australia.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Toms, Leisa-Maree L
AU  - Toms LL
AD  - School of Public Health and Social Work and Institute of Health and Biomedical 
      Innovation, Queensland University of Technology, Brisbane, Australia; The 
      University of Queensland, Queensland Alliance for Environmental Sciences, 
      Australia. Electronic address: leisamaree.toms@qut.edu.au.
FAU - Sjodin, Andreas
AU  - Sjodin A
AD  - Centers for Disease Control and Prevention, Atlanta, USA; The University of 
      Queensland, Queensland Alliance for Environmental Sciences, Australia.
FAU - Hobson, Peter
AU  - Hobson P
AD  - Sullivan Nicolaides Pathology, Brisbane, Australia.
FAU - Harden, Fiona A
AU  - Harden FA
AD  - Hunter Industrial Medicine, Newcastle, Australia.
FAU - Aylward, Lesa L
AU  - Aylward LL
AD  - Summit Toxicology, Falls Church, VA, USA; The University of Queensland, 
      Queensland Alliance for Environmental Sciences, Australia.
FAU - Mueller, Jochen F
AU  - Mueller JF
AD  - The University of Queensland, Queensland Alliance for Environmental Sciences, 
      Australia.
LA  - eng
GR  - CC999999/Intramural CDC HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180920
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Australia
MH  - Child
MH  - Child, Preschool
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Halogenated Diphenyl Ethers/*blood
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Young Adult
PMC - PMC6263174
MID - NIHMS996154
EDAT- 2018/09/23 06:00
MHDA- 2019/04/04 06:00
PMCR- 2019/12/01
CRDT- 2018/09/23 06:00
PHST- 2018/06/12 00:00 [received]
PHST- 2018/08/07 00:00 [revised]
PHST- 2018/09/07 00:00 [accepted]
PHST- 2018/09/23 06:00 [pubmed]
PHST- 2019/04/04 06:00 [medline]
PHST- 2018/09/23 06:00 [entrez]
PHST- 2019/12/01 00:00 [pmc-release]
AID - S0160-4120(18)31172-3 [pii]
AID - 10.1016/j.envint.2018.09.014 [doi]
PST - ppublish
SO  - Environ Int. 2018 Dec;121(Pt 1):357-364. doi: 10.1016/j.envint.2018.09.014. Epub 
      2018 Sep 20.