PMID- 30243773
OWN - NLM
STAT- MEDLINE
DCOM- 20190610
LR  - 20190613
IS  - 1879-3061 (Electronic)
IS  - 1043-2760 (Linking)
VI  - 29
IP  - 12
DP  - 2018 Dec
TI  - An Evolutionary Perspective on the Obesity Epidemic.
PG  - 819-826
LID - S1043-2760(18)30163-2 [pii]
LID - 10.1016/j.tem.2018.09.002 [doi]
AB  - An evolutionary approach to obesity involves a genomic/anthropological dimension. 
      For 1.8 Myr the lifestyle of hunter-gatherers (HGs) comprised intense physical 
      activity and a high-protein/low-carbohydrate diet. Genomes of HGs were adapted to 
      low insulin sensitivity. When the agrarian epoch began a new 'farmer diet' high 
      in carbohydrates (CHO) emerged. Owing to periodic famines, the genome may not 
      have adapted; they preserved a HG genome. Ever since the industrial revolution 
      our genome is adapting rapidly to a CHO-rich diet. Individuals with preserved HG 
      genome develop obesity at age 4-8 years and need a low-CHO diet. By contrast, 
      those with a farmer genome become obese in infancy; they need a low-calorie diet. 
      This knowledge prompts exploration of the two genomes and their clinical 
      presentations.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Hochberg, Z
AU  - Hochberg Z
AD  - Faculty of Medicine, Technion - Israel Institute of Technology, 31096 Haifa, 
      Israel; https://md.technion.ac.il/faculty_member/zeev-hochberg/. Electronic 
      address: rprzeev@technion.ac.il.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180919
PL  - United States
TA  - Trends Endocrinol Metab
JT  - Trends in endocrinology and metabolism: TEM
JID - 9001516
SB  - IM
MH  - *Biological Evolution
MH  - *Caloric Restriction
MH  - *Diet, High-Protein
MH  - *Genome, Human
MH  - Humans
MH  - Obesity/*diet therapy/*genetics
OTO - NOTNLM
OT  - agrarian epoch
OT  - human evolution
OT  - industrial revolution
OT  - obesity
EDAT- 2018/09/24 06:00
MHDA- 2019/06/14 06:00
CRDT- 2018/09/24 06:00
PHST- 2018/07/05 00:00 [received]
PHST- 2018/08/23 00:00 [revised]
PHST- 2018/09/04 00:00 [accepted]
PHST- 2018/09/24 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2018/09/24 06:00 [entrez]
AID - S1043-2760(18)30163-2 [pii]
AID - 10.1016/j.tem.2018.09.002 [doi]
PST - ppublish
SO  - Trends Endocrinol Metab. 2018 Dec;29(12):819-826. doi: 10.1016/j.tem.2018.09.002. 
      Epub 2018 Sep 19.