PMID- 30244363
OWN - NLM
STAT- MEDLINE
DCOM- 20190211
LR  - 20190215
IS  - 1435-4373 (Electronic)
IS  - 0934-9723 (Linking)
VI  - 37
IP  - 12
DP  - 2018 Dec
TI  - Vaginal Ureaplasma species increase chorioamnionitis in very preterm infants with 
      preterm premature rupture of the membranes at < 28 weeks of gestation.
PG  - 2371-2380
LID - 10.1007/s10096-018-3385-5 [doi]
AB  - Our aim was to investigate the association between vaginal Ureaplasma species 
      (spp.) and the subsequent occurrence of chorioamnionitis (CAM), perinatal death, 
      neonatal morbidity, and long-term neurodevelopmental impairments (NDIs) at 
      3 years of age. We analyzed 55 pregnant women with singleton pregnancy who had 
      preterm premature rupture of the membranes (pPROM) at < 28(+0) weeks of 
      gestation, and delivered between 22(+0) and 31(+6) weeks at our tertiary hospital 
      in 2007-2016. NDIs were defined as either cerebral palsy or developmental delay 
      evaluated at 1.5 and/or 3 years old. The presence of Ureaplasma spp. and 
      Mycoplasma hominis were evaluated using urea-arginine broth and Mycoplasma PPLO 
      Agar. The presence of Ureaplasma spp. in the vagina was positive in 41%. Vaginal 
      Ureaplasma spp. was a significant risk factor for CAM; however, it was not 
      significantly associated with the occurrence of perinatal death, pulmonary 
      hypoplasia, respiratory distress syndrome, transient tachypnea of the newborn, 
      intraventricular hemorrhage, periventricular leukomalacia, bronchopulmonary 
      dysplasia defined as oxygen required and occasional ventilatory assistance 
      required at week 36 as modified (BPD(36)), or NDIs. The crude odds ratio (95% 
      confidence interval) of Ureaplasma spp. for the occurrence of CAM was 9.5 
      (1.10-82) (p = 0.041). In very preterm birth infants with pPROM, CAM, BPD(36), 
      and NDIs occurred in 78, 60, and 36%, respectively. Vaginal Ureaplasma spp. was a 
      significant risk factor for CAM in very preterm birth infants with pPROM. The 
      incidences of BPD(36) and NDIs in such infants were very high, nearing 3/5 and 
      1/3, respectively.
FAU - Suzuki, Yu
AU  - Suzuki Y
AD  - Department of Pediatrics, Jichi Medical University School of Medicine, Tochigi, 
      Japan.
FAU - Horie, Kenji
AU  - Horie K
AD  - Department of Obstetrics and Gynecology, Jichi Medical University School of 
      Medicine, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi, 329-0498, Japan.
FAU - Yada, Yukari
AU  - Yada Y
AD  - Department of Pediatrics, Jichi Medical University School of Medicine, Tochigi, 
      Japan.
FAU - Kono, Yumi
AU  - Kono Y
AD  - Department of Pediatrics, Jichi Medical University School of Medicine, Tochigi, 
      Japan.
FAU - Hirashima, Chikako
AU  - Hirashima C
AD  - Department of Obstetrics and Gynecology, Jichi Medical University School of 
      Medicine, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi, 329-0498, Japan.
FAU - Usui, Rie
AU  - Usui R
AD  - Department of Obstetrics and Gynecology, Jichi Medical University School of 
      Medicine, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi, 329-0498, Japan.
FAU - Matsubara, Shigeki
AU  - Matsubara S
AD  - Department of Obstetrics and Gynecology, Jichi Medical University School of 
      Medicine, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi, 329-0498, Japan.
FAU - Ohkuchi, Akihide
AU  - Ohkuchi A
AUID- ORCID: 0000-0002-8861-1572
AD  - Department of Obstetrics and Gynecology, Jichi Medical University School of 
      Medicine, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi, 329-0498, Japan. 
      okuchi@jichi.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20180922
PL  - Germany
TA  - Eur J Clin Microbiol Infect Dis
JT  - European journal of clinical microbiology & infectious diseases : official 
      publication of the European Society of Clinical Microbiology
JID - 8804297
RN  - Preterm Premature Rupture of the Membranes
SB  - IM
MH  - Adult
MH  - Child, Preschool
MH  - Chorioamnionitis/*microbiology
MH  - Female
MH  - Fetal Membranes, Premature Rupture/*etiology/microbiology
MH  - *Gestational Age
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Mycoplasma Infections/complications
MH  - Mycoplasma hominis/isolation & purification
MH  - Neurodevelopmental Disorders/etiology
MH  - Perinatal Mortality
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/*microbiology
MH  - Pregnancy Outcome
MH  - Premature Birth
MH  - Risk Factors
MH  - Ureaplasma/isolation & purification
MH  - Ureaplasma Infections/*complications
MH  - Vagina/*microbiology
OTO - NOTNLM
OT  - Chorioamnionitis
OT  - Neurodevelopmental impairments
OT  - Perinatal death
OT  - Preterm premature rupture of the membranes
OT  - Ureaplasma species
OT  - Very preterm
EDAT- 2018/09/24 06:00
MHDA- 2019/02/12 06:00
CRDT- 2018/09/24 06:00
PHST- 2018/08/20 00:00 [received]
PHST- 2018/09/18 00:00 [accepted]
PHST- 2018/09/24 06:00 [pubmed]
PHST- 2019/02/12 06:00 [medline]
PHST- 2018/09/24 06:00 [entrez]
AID - 10.1007/s10096-018-3385-5 [pii]
AID - 10.1007/s10096-018-3385-5 [doi]
PST - ppublish
SO  - Eur J Clin Microbiol Infect Dis. 2018 Dec;37(12):2371-2380. doi: 
      10.1007/s10096-018-3385-5. Epub 2018 Sep 22.