PMID- 30245555
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 0961-205X (Print)
IS  - 1467-9507 (Electronic)
IS  - 0961-205X (Linking)
VI  - 27
IP  - 3
DP  - 2018 Aug
TI  - The BDNF gene val66met polymorphism and behavioral inhibition in early childhood.
PG  - 543-554
LID - 10.1111/sode.12292 [doi]
AB  - Stably elevated behavioural inhibition (BI) is an established risk factor for 
      internalizing disorders. This stability may be related to genetic factors, 
      including a valine-to-methionine substitution on codon 66 (val66met) of the 
      brain-derived neurotrophic factor (BDNF) gene. Past work on the BDNF met variant 
      has inconsistently linked it to vulnerability to internalizing problems; some of 
      this inconsistency may stem from the failure to consider gene-trait interactions 
      in shaping the course of early BI. Toward elucidating early pathways to anxiety 
      vulnerability, we examined gene-by-trait interactions in predicting the course of 
      BI over time in 476 children, assessed for BI using standardized laboratory 
      methods. We found that children with the met allele showed lower stability of BI 
      between ages 3 and 6 than those without this allele. While the mechanisms that 
      underlie this effect are unclear, our findings are consistent with the notion 
      that the met variant, in the context of early BI, influences the stability of 
      this trait in early development.
FAU - Vandermeer, Matthew R J
AU  - Vandermeer MRJ
FAU - Sheikh, Haroon I
AU  - Sheikh HI
FAU - Singh, Shiva S
AU  - Singh SS
FAU - Klein, Daniel N
AU  - Klein DN
FAU - Olino, Thomas M
AU  - Olino TM
FAU - Dyson, Margaret W
AU  - Dyson MW
FAU - Bufferd, Sara J
AU  - Bufferd SJ
FAU - Hayden, Elizabeth P
AU  - Hayden EP
LA  - eng
GR  - R01 MH069942/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20180313
PL  - England
TA  - Soc Dev
JT  - Social development (Oxford, England)
JID - 101246621
PMC - PMC6142175
MID - NIHMS950659
OTO - NOTNLM
OT  - BDNF
OT  - Gene-trait interaction
OT  - behavioural inhibition
OT  - children
OT  - laboratory assessment
OT  - val66met
EDAT- 2018/09/25 06:00
MHDA- 2018/09/25 06:01
PMCR- 2019/08/01
CRDT- 2018/09/25 06:00
PHST- 2018/09/25 06:00 [entrez]
PHST- 2018/09/25 06:00 [pubmed]
PHST- 2018/09/25 06:01 [medline]
PHST- 2019/08/01 00:00 [pmc-release]
AID - 10.1111/sode.12292 [doi]
PST - ppublish
SO  - Soc Dev. 2018 Aug;27(3):543-554. doi: 10.1111/sode.12292. Epub 2018 Mar 13.