PMID- 30245878
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 2090-2085 (Print)
IS  - 2090-2093 (Electronic)
IS  - 2090-2093 (Linking)
VI  - 2018
DP  - 2018
TI  - Long-Acting Injectable Second-Generation Antipsychotics Improve Negative Symptoms 
      and Suicidal Ideation in Recent Diagnosed Schizophrenia Patients: A 1-Year 
      Follow-up Pilot Study.
PG  - 4834135
LID - 10.1155/2018/4834135 [doi]
LID - 4834135
AB  - Long-acting injectable second-generation antipsychotics (LAI-SGA) are typically 
      used to maintain treatment adherence in patients with chronic schizophrenia. 
      Recent research suggests that they may also provide an effective treatment 
      strategy for patients with early-phase disease. The aim of this study is to 
      evaluate clinical and psychosocial outcomes among recent and long-term diagnosed 
      schizophrenia outpatients treated with LAI-SGA during a follow-up period of 12 
      months. Stable schizophrenia patients receiving LAI-SGA with 5 or less years of 
      illness duration (n = 10) were compared to those with more than 5 years of 
      illness duration (n = 15). Clinical data was assessed through the Positive and 
      Negative Syndrome Scale (PANSS), the Global Assessment of Functioning (GAF), the 
      Columbia Suicide Severity Rating Scale (C-SSRS), the Recovery Style Questionnaire 
      (RSQ), and the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) Managing 
      Emotion branch. Recently diagnosed patients showed greater improvement versus 
      patients diagnosed for more than 5 years in adjusted mean GAF score, in PANSS 
      factor score for negative and depressive symptoms, and in severity and intensity 
      of suicidal ideation. Our preliminary findings support the hypothesis that 
      LAI-SGA may influence the course of the illness if administered at the early 
      phase of the illness. However, replicate studies are needed, possibly with larger 
      samples.
FAU - Corigliano, Valentina
AU  - Corigliano V
AUID- ORCID: 0000-0003-2534-5518
AD  - Department of Neurosciences, Unit of Psychiatry, Sapienza University of Rome, 
      School of Medicine and Psychology, Via di Grottarossa 1035-39, 00198 Rome, Italy.
FAU - Comparelli, Anna
AU  - Comparelli A
AUID- ORCID: 0000-0003-4557-0931
AD  - Department of Neurosciences, Unit of Psychiatry, Sapienza University of Rome, 
      School of Medicine and Psychology, Via di Grottarossa 1035-39, 00198 Rome, Italy.
FAU - Mancinelli, Iginia
AU  - Mancinelli I
AD  - Department of Neurosciences, Unit of Psychiatry, Sapienza University of Rome, 
      School of Medicine and Psychology, Via di Grottarossa 1035-39, 00198 Rome, Italy.
FAU - Montalbani, Benedetta
AU  - Montalbani B
AD  - Department of Neurosciences, Unit of Psychiatry, Sapienza University of Rome, 
      School of Medicine and Psychology, Via di Grottarossa 1035-39, 00198 Rome, Italy.
FAU - Lamis, Dorian A
AU  - Lamis DA
AUID- ORCID: 0000-0001-5405-0239
AD  - Department of Psychiatry and Behavioral Sciences, Emory School of Medicine, Grady 
      Hospital, Atlanta, GA, USA.
FAU - De Carolis, Antonella
AU  - De Carolis A
AD  - Department of Neurosciences, Unit of Neurology, Sapienza University of Rome, 
      School of Medicine and Psychology, Via di Grottarossa 1035-39, 00198 Rome, Italy.
FAU - Erbuto, Denise
AU  - Erbuto D
AD  - Department of Neurosciences, Unit of Psychiatry, Sapienza University of Rome, 
      School of Medicine and Psychology, Via di Grottarossa 1035-39, 00198 Rome, Italy.
FAU - Girardi, Paolo
AU  - Girardi P
AD  - Department of Neurosciences, Unit of Psychiatry, Sapienza University of Rome, 
      School of Medicine and Psychology, Via di Grottarossa 1035-39, 00198 Rome, Italy.
FAU - Pompili, Maurizio
AU  - Pompili M
AD  - Department of Neurosciences, Unit of Psychiatry, Sapienza University of Rome, 
      School of Medicine and Psychology, Via di Grottarossa 1035-39, 00198 Rome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20180830
PL  - Egypt
TA  - Schizophr Res Treatment
JT  - Schizophrenia research and treatment
JID - 101576450
PMC - PMC6136552
EDAT- 2018/09/25 06:00
MHDA- 2018/09/25 06:01
PMCR- 2018/08/30
CRDT- 2018/09/25 06:00
PHST- 2018/05/30 00:00 [received]
PHST- 2018/07/31 00:00 [revised]
PHST- 2018/08/14 00:00 [accepted]
PHST- 2018/09/25 06:00 [entrez]
PHST- 2018/09/25 06:00 [pubmed]
PHST- 2018/09/25 06:01 [medline]
PHST- 2018/08/30 00:00 [pmc-release]
AID - 10.1155/2018/4834135 [doi]
PST - epublish
SO  - Schizophr Res Treatment. 2018 Aug 30;2018:4834135. doi: 10.1155/2018/4834135. 
      eCollection 2018.