PMID- 30246695
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1735-367X (Electronic)
IS  - 1735-1383 (Linking)
VI  - 15
IP  - 3
DP  - 2018 Sep
TI  - Lower Frequency of HLA-DRB1*01 in Southwestern Iranian Patients with 
      Atherosclerosis.
PG  - 197-206
LID - 10.22034/IJI.2018.39389 [doi]
AB  - BACKGROUND: Human leukocyte antigen (HLA) complex is a gene family involved in 
      antigen presentation associated with protection or susceptibility to 
      inflammatory, infectious and autoimmune diseases. Atherosclerosis is a chronic 
      inflammatory disease in which HLA molecules play a role in the initiation and 
      development of the disease through presentation of self or foreign antigens to T 
      cells. OBJECTIVE: To investigate the association of HLA-DRB1 alleles with 
      atherosclerosis in a sample of southwestern Iranians. METHODS: We performed an 
      analytical cross-sectional study involving 96 patients with atherosclerosis and 
      72 controls. HLA-DRB1 genotyping was performed by PCR-SSP method. RESULTS: We 
      observed a significantly lower frequency of DRB1*01 in patients with coronary 
      artery atherosclerosis than in controls (4.68% vs. 13.1, P=0.0052, OR=3.09, CI 
      95%: 1.35-7.05). However, this allele showed a positive association with high 
      blood pressure (P=0.009) in patients. Furthermore, DRB1*16 allele was associated 
      with hyperlipidemia (P=0.008) in patients. CONCLUSION: Our results demonstrated 
      that DRB1*01 may be a protective allele against atherosclerosis in individuals 
      who live in southwest of Iran. The mechanism of this protection needs further 
      investigation.
FAU - Golmoghaddam, Hossein
AU  - Golmoghaddam H
AD  - Department of Immunology, School of Medicine, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
FAU - Farjadian, Shirin
AU  - Farjadian S
FAU - Khosropanah, Shahdad
AU  - Khosropanah S
FAU - Dehghani, Pooyan
AU  - Dehghani P
FAU - Doroudchi, Mehrnoosh
AU  - Doroudchi M
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Immunol
JT  - Iranian journal of immunology : IJI
JID - 101282932
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*01 antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigen Presentation/genetics
MH  - Atherosclerosis/*genetics/immunology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - *Genotype
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Hypertension/*genetics
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
EDAT- 2018/09/25 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/09/25 06:00
PHST- 2018/09/25 06:00 [entrez]
PHST- 2018/09/25 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
AID - 04 [pii]
AID - 10.22034/IJI.2018.39389 [doi]
PST - ppublish
SO  - Iran J Immunol. 2018 Sep;15(3):197-206. doi: 10.22034/IJI.2018.39389.