PMID- 30246715 OWN - NLM STAT- MEDLINE DCOM- 20181211 LR - 20220330 IS - 2542-5641 (Electronic) IS - 0366-6999 (Print) IS - 0366-6999 (Linking) VI - 131 IP - 19 DP - 2018 Oct 5 TI - Effects of Risperidone and Paliperidone on Brain-Derived Neurotrophic Factor and N400 in First-Episode Schizophrenia. PG - 2297-2301 LID - 10.4103/0366-6999.241802 [doi] AB - BACKGROUND: Risperidone and paliperidone have been the mainstay treatment for schizophrenia and their potential role in neuroprotection could be associated with brain-derived neurotrophic factor (BDNF) and N400 (an event-related brain potential component). So far, different effects on both BDNF and N400 were reported in relation to various antipsychotic treatments. However, few studies have been conducted on the mechanism of risperidone and paliperidone on BDNF and N400. This study aimed to compare the effects of risperidone and paliperidone on BDNF and the N400 component of the event-related brain potential in patients with first-episode schizophrenia. METHODS: Ninety-eight patients with first-episode schizophrenia were randomly divided into the risperidone and paliperidone groups and treated with risperidone and paliperidone, respectively, for 12 weeks. Serum BDNF level, the latency, and amplitude of the N400 event-related potential before and after the treatment and Positive and Negative Syndrome Scale (PANSS) scores were compared between the two groups. RESULTS: A total of 94 patients were included in the final analysis (47 patients in each group). After the treatment, the serum BDNF levels in both groups increased (all P < 0.01), while no significant difference in serum BDNF level was found between the groups before and after the treatment (all P > 0.05). After the treatment, N400 amplitudes were increased (from 4.73 +/- 2.86 muv and 4.51 +/- 4.63 muv to 5.35 +/- 4.18 muv and 5.52 +/- 3.08 muv, respectively) under congruent condition in both risperidone and paliperidone groups (all P < 0.01). Under incongruent conditions, the N400 latencies were shortened in the paliperidone group (from 424.13 +/- 110.42 ms to 4.7.41 +/- 154.59 ms, P < 0.05), and the N400 amplitudes were increased in the risperidone group (from 5.80 +/- 3.50 muv to 7.17 +/- 5.51 muv, P < 0.01). After treatment, the total PANSS score in both groups decreased significantly (all P < 0.01), but the difference between the groups was not significant (P > 0.05). A negative correlation between the reduction rate of the PANSS score and the increase in serum BDNF level after the treatment was found in the paliperidone group but not in the risperidone group. CONCLUSIONS: Both risperidone and paliperidone could increase the serum BDNF levels in patients with first-episode schizophrenia and improve their cognitive function (N400 latency and amplitude), but their antipsychotic mechanisms might differ. FAU - Wu, Rong-Qin AU - Wu RQ AD - Department of Psychiatry, Shanghai Jingan Mental Health Center, Shanghai 200436, China. FAU - Lin, Chong-Guang AU - Lin CG AD - Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang 325005, China. FAU - Zhang, Wei AU - Zhang W AD - Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang 325005, China. FAU - Lin, Xiao-Dong AU - Lin XD AD - Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang 325005, China. FAU - Chen, Xing-Shi AU - Chen XS AD - Department of Electrophysiology, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China. FAU - Chen, Ce AU - Chen C AD - Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang 325005, China. FAU - Zhang, Li-Jun AU - Zhang LJ AD - Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang 325005, China. FAU - Huang, Zi-Ye AU - Huang ZY AD - Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang 325005, China. FAU - Chen, Guang-Dong AU - Chen GD AD - Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang 325005, China. FAU - Xu, Da-Li AU - Xu DL AD - Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang 325005, China. FAU - Lin, Zhi-Guang AU - Lin ZG AD - Department of Electrophysiology, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China. FAU - Zhang, Ming-Dao AU - Zhang MD AD - Department of Electrophysiology, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China. LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - China TA - Chin Med J (Engl) JT - Chinese medical journal JID - 7513795 RN - 0 (Antipsychotic Agents) RN - 0 (Brain-Derived Neurotrophic Factor) RN - L6UH7ZF8HC (Risperidone) RN - R8P8USM8FR (Paliperidone Palmitate) SB - IM MH - Antipsychotic Agents/*pharmacology MH - Brain-Derived Neurotrophic Factor/*drug effects MH - China MH - Electroencephalography MH - Evoked Potentials/drug effects MH - Female MH - Humans MH - Male MH - Paliperidone Palmitate/*pharmacology MH - Risperidone/*pharmacology MH - Schizophrenia/*drug therapy PMC - PMC6166445 OTO - NOTNLM OT - Brain-Derived Neurotrophic Factor OT - Cognitive Function OT - Event-Related Potentials OT - N400 OT - Schizophrenia COIS- There are no conflicts of interest EDAT- 2018/09/25 06:00 MHDA- 2018/12/12 06:00 PMCR- 2018/10/05 CRDT- 2018/09/25 06:00 PHST- 2018/09/25 06:00 [entrez] PHST- 2018/09/25 06:00 [pubmed] PHST- 2018/12/12 06:00 [medline] PHST- 2018/10/05 00:00 [pmc-release] AID - ChinMedJ_2018_131_19_2297_241802 [pii] AID - CMJ-131-2297 [pii] AID - 10.4103/0366-6999.241802 [doi] PST - ppublish SO - Chin Med J (Engl). 2018 Oct 5;131(19):2297-2301. doi: 10.4103/0366-6999.241802.