PMID- 30246883
OWN - NLM
STAT- MEDLINE
DCOM- 20200317
LR  - 20200317
IS  - 1365-2265 (Electronic)
IS  - 0300-0664 (Linking)
VI  - 90
IP  - 1
DP  - 2019 Jan
TI  - Effect of vitamin D supplementation along with weight loss diet on 
      meta-inflammation and fat mass in obese subjects with vitamin D deficiency: A 
      double-blind placebo-controlled randomized clinical trial.
PG  - 94-101
LID - 10.1111/cen.13861 [doi]
AB  - BACKGROUND & AIMS: Low serum 25-hydroxyvitamin D (25OHD) is common in obese 
      people. Obesity is associated with a state of low-grade inflammation 
      (meta-inflammation). There is an increasing evidence indicating that vitamin D 
      has anti-adipogenic activity and immunoregulatory effect. This study aimed to 
      assess the effect of vitamin D supplementation on meta-inflammation and fat mass 
      in obese subjects with vitamin D deficiency. MATERIALS AND METHODS: In this 
      double-blind placebo-controlled randomized clinical trial, 44 obese subjects with 
      vitamin D deficiency (25OHD < 50 nmol/L) were assigned into vitamin D (a weight 
      reduction diet + bolus weekly dose of 50 000 IU vitamin D) or placebo group 
      (weight reduction diet + edible paraffin weekly) for 12 weeks. Weight, fat mass 
      and serum levels of 25OHD, calcium, parathyroid hormone (PTH), monocyte 
      chemoattractant protein-1 (MCP-1), interleukin-1beta (IL-1beta) and Toll-like receptor 
      4 (TLR4) were assessed before and after the intervention. RESULTS: Vitamin D 
      supplementation resulted in significant increase of serum 25OHD level 
      (P < 0.001), and significant decrease in PTH (P < 0.001), MCP-1 (P < 0.05), IL-1beta 
      (P < 0.05) and TLR-4 (P < 0.05); compared to the baseline values in vitamin D 
      group. Weight, BMI and fat mass decreased in both groups (P < 0.05). Between the 
      groups, there were significant decrease in weight, fat mass, serum MCP-1 and PTH 
      concentrations and significant increase in serum 25OHD concentrations after 
      intervention with vitamin D supplementation compared to placebo (P < 0.05). 
      CONCLUSIONS: Improvement in vitamin D status in obese subjects with vitamin D 
      deficiency in combination with weight loss diet resulted in weight, fat mass and 
      MCP-1 decrease. Weight loss and vitamin D supplementation may act synergistically 
      to reduce levels of meta-inflammation.
CI  - (c) 2018 John Wiley & Sons Ltd.
FAU - Lotfi-Dizaji, Lida
AU  - Lotfi-Dizaji L
AUID- ORCID: 0000-0003-0800-2660
AD  - Student Research Committee, Faculty of Nutrition and Food Science, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
FAU - Mahboob, Soltanali
AU  - Mahboob S
AUID- ORCID: 0000-0001-7102-0437
AD  - Nutritional Biochemistry, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
FAU - Aliashrafi, Soodabeh
AU  - Aliashrafi S
AUID- ORCID: 0000-0003-1642-0934
AD  - Student Research Committee, Faculty of Nutrition and Food Science, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
FAU - Vaghef-Mehrabany, Elnaz
AU  - Vaghef-Mehrabany E
AUID- ORCID: 0000-0003-0890-2618
AD  - Student Research Committee, Faculty of Nutrition and Food Science, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
FAU - Ebrahimi-Mameghani, Mehrangiz
AU  - Ebrahimi-Mameghani M
AUID- ORCID: 0000-0002-0311-1289
AD  - Nutrition Research Center, Faculty of Nutrition & Food Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
FAU - Morovati, Ashti
AU  - Morovati A
AUID- ORCID: 0000-0002-2812-1766
AD  - Student Research Committee, Faculty of Nutrition and Food Science, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20181112
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Adipose Tissue/pathology
MH  - Adolescent
MH  - Adult
MH  - *Body Fat Distribution
MH  - Body Mass Index
MH  - Chemokine CCL2/blood
MH  - *Diet, Reducing
MH  - *Dietary Supplements
MH  - Female
MH  - Humans
MH  - Inflammation/*therapy
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - Obesity/complications/pathology/*therapy
MH  - Vitamin D/*analogs & derivatives/pharmacology/therapeutic use
MH  - Vitamin D Deficiency/*drug therapy
MH  - Young Adult
OTO - NOTNLM
OT  - fat mass
OT  - meta-inflammation
OT  - obesity
OT  - vitamin D supplementation
OT  - weight loss
EDAT- 2018/09/25 06:00
MHDA- 2020/03/18 06:00
CRDT- 2018/09/25 06:00
PHST- 2018/07/11 00:00 [received]
PHST- 2018/09/15 00:00 [revised]
PHST- 2018/09/19 00:00 [accepted]
PHST- 2018/09/25 06:00 [pubmed]
PHST- 2020/03/18 06:00 [medline]
PHST- 2018/09/25 06:00 [entrez]
AID - 10.1111/cen.13861 [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 2019 Jan;90(1):94-101. doi: 10.1111/cen.13861. Epub 2018 
      Nov 12.