PMID- 30247509
OWN - NLM
STAT- MEDLINE
DCOM- 20200330
LR  - 20200330
IS  - 1529-7268 (Electronic)
IS  - 0006-3363 (Linking)
VI  - 100
IP  - 2
DP  - 2019 Feb 1
TI  - Intentional endometrial injury increases embryo implantation potentials through 
      enhanced endometrial angiogenesisdagger.
PG  - 381-389
LID - 10.1093/biolre/ioy205 [doi]
AB  - Embryo implantation rates have been found to be enhanced by precedent endometrial 
      injuries, but the underlying mechanism is not fully investigated. Endometrial 
      inflammation occurs both at peri-implantation period and after endometrial 
      injury, in which vascular reaction is a distinctive feature of inflammation. In 
      this study, intentional endometrial injury was done with a 0.7-mm-diameter brush 
      inserted into the left uterine horn of female ICR mice, then turned around 720 degrees  
      (group 2), and the right uterine horn served as the controls without endometrial 
      injuries (group 1). Intraperitoneal equine chorionic gonadotropin 2.5 IU was 
      injected, followed by human chorionic gonadotropin 10 IU injection, and the 
      uterus was dissected 5 days later, roughly at the peri-implantation period. The 
      peri-implantation endometrium was obtained, and angiogenesis protein array 
      revealed that matrix metalloproteinase-3 (MMP-3), plasminogen activator 
      inhibitor-1 (PAI-1), insulin-like growth factor binding protein 1 (IGFBP-1), and 
      IL-1alpha were more strongly expressed in injured endometrium (group 2) than in the 
      controls (group 1). Immunohistochemical CD34 staining was more prominently 
      expressed in group 2 uterus, and the treatment with LY294002, a phosphoinositide 
      3-kinase (PI3K) inhibitor, significantly decreased CD34 immunopositive cells. The 
      capabilities of permeability, proliferation, tube formation, and migration of 
      mouse endometrial endothelial cells were significantly enhanced in group 2 than 
      in group 1. Our results demonstrate that enhanced endometrial angiogenesis is a 
      possible mechanism accounting for the increased endometrial receptivity after 
      endometrial injury.
CI  - (c) The Author(s) 2018. Published by Oxford University Press on behalf of Society 
      for the Study of Reproduction.
FAU - Yang, Jehn-Hsiahn
AU  - Yang JH
AD  - Department of Obstetrics and Gynecology, National Taiwan University Hospital and 
      National Taiwan University College of Medicine, Taipei, Taiwan.
FAU - Chen, Chin-Der
AU  - Chen CD
AD  - Department of Obstetrics and Gynecology, Fu Jen Catholic University Hospital, 
      Taipei, Taiwan.
FAU - Chou, Chia-Hung
AU  - Chou CH
AD  - Department of Obstetrics and Gynecology, National Taiwan University Hospital and 
      National Taiwan University College of Medicine, Taipei, Taiwan.
FAU - Wen, Wen-Fen
AU  - Wen WF
AD  - Department of Pathology, National Taiwan University Hospital and National Taiwan 
      University College of Medicine, Taipei, Taiwan.
FAU - Tsao, Po-Nien
AU  - Tsao PN
AD  - Department of Pediatrics, National Taiwan University Hospital and National Taiwan 
      University College of Medicine, Taipei, Taiwan.
FAU - Lee, Hsinyu
AU  - Lee H
AD  - Department of Life Science, National Taiwan University, Taipei, Taiwan.
FAU - Chen, Shee-Uan
AU  - Chen SU
AD  - Department of Obstetrics and Gynecology, National Taiwan University Hospital and 
      National Taiwan University College of Medicine, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biol Reprod
JT  - Biology of reproduction
JID - 0207224
RN  - 0 (Chorionic Gonadotropin)
SB  - IM
MH  - Animals
MH  - Chorionic Gonadotropin/administration & dosage/pharmacology
MH  - Embryo Implantation/*physiology
MH  - Endometrium/drug effects/*injuries/*physiology
MH  - Endothelial Cells/physiology
MH  - Female
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Neovascularization, Physiologic
MH  - Pregnancy
OTO - NOTNLM
OT  - angiogenesis
OT  - embryo implantation
OT  - endometrial injury
OT  - endometrial receptivity
EDAT- 2018/09/25 06:00
MHDA- 2020/03/31 06:00
CRDT- 2018/09/25 06:00
PHST- 2018/07/09 00:00 [received]
PHST- 2018/08/03 00:00 [revised]
PHST- 2018/09/20 00:00 [accepted]
PHST- 2018/09/25 06:00 [pubmed]
PHST- 2020/03/31 06:00 [medline]
PHST- 2018/09/25 06:00 [entrez]
AID - 5105746 [pii]
AID - 10.1093/biolre/ioy205 [doi]
PST - ppublish
SO  - Biol Reprod. 2019 Feb 1;100(2):381-389. doi: 10.1093/biolre/ioy205.