PMID- 3024852
OWN - NLM
STAT- MEDLINE
DCOM- 19870210
LR  - 20131121
IS  - 0392-906X (Print)
IS  - 0392-906X (Linking)
VI  - 5
IP  - 5
DP  - 1986 Oct
TI  - Combination chemotherapy for non small cell lung cancer stage III M0-1 with 
      cisplatin and vinblastine in a divided-dose schedule.
PG  - 351-5
AB  - Twenty-nine patients with advanced non small cell lung cancer (NSCLC) were 
      treated with a combination of high-dose cisplatin and divided-dose vinblastine. 
      In 27 evaluable patients 15% reached partial response and 59% stable disease. 
      Extension of disease, histological type, performance status and weight loss had 
      no relationship to response. Median duration of response was 10.2 months with a 
      median survival time of 15.4 months in responding patients compared with 14 
      months of stable disease (p:n.s.) and 4.8 months of progressive disease (p less 
      than 0.001). Gastrointestinal, neurological side effects and the development of a 
      severe debilitation syndrome were the most troublesome toxicities of this 
      treatment. The regimen is not generally suitable for treatment of advanced NSCLC.
FAU - Scagliotti, G V
AU  - Scagliotti GV
FAU - Bardessono, F
AU  - Bardessono F
FAU - Gozzelino, F
AU  - Gozzelino F
FAU - D'Apuzzo, C
AU  - D'Apuzzo C
FAU - Albera, C
AU  - Albera C
FAU - Pescetti, G
AU  - Pescetti G
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Chemioterapia
JT  - Chemioterapia : international journal of the Mediterranean Society of 
      Chemotherapy
JID - 8401667
RN  - 5V9KLZ54CY (Vinblastine)
RN  - AYI8EX34EU (Creatinine)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Carcinoma, Non-Small-Cell Lung/*drug therapy
MH  - Cisplatin/administration & dosage
MH  - Creatinine/blood
MH  - Drug Administration Schedule
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Vinblastine/administration & dosage
EDAT- 1986/10/01 00:00
MHDA- 1986/10/01 00:01
CRDT- 1986/10/01 00:00
PHST- 1986/10/01 00:00 [pubmed]
PHST- 1986/10/01 00:01 [medline]
PHST- 1986/10/01 00:00 [entrez]
PST - ppublish
SO  - Chemioterapia. 1986 Oct;5(5):351-5.