PMID- 30248919
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240512
IS  - 2306-5354 (Print)
IS  - 2306-5354 (Electronic)
IS  - 2306-5354 (Linking)
VI  - 5
IP  - 4
DP  - 2018 Sep 21
TI  - Non-Inherited Maternal Antigens Identify Acceptable HLA Mismatches: A New Policy 
      for the Hellenic Cord Blood Bank.
LID - 10.3390/bioengineering5040077 [doi]
LID - 77
AB  - BACKGROUND: During pregnancy, the maternal-fetal contact may lead to the 
      development of tolerance against the maternal human leukocyte antigen (HLA) that 
      is not inherited by the fetus. These non-inherited maternal antigens (NIMAs) 
      define acceptable HLA mismatches; therefore, the number of HLA phenotypes that 
      are suitable matches for patients who need a hematopoietic stem cell transplant 
      could be increased. Cord blood unit (CBU) transplantations to patients mismatched 
      for a HLA loci, but similar to the NuIotaMuAs of the CBU, have a prognosis similar to 
      6/6-matched ones. METHODS: The Hellenic Cord Blood Bank (HCBB) identified the 
      maternal HLA of 380 cord blood donors, specifying the NIMA haplotypes of the 
      related cryostored CBUs. RESULTS: The HCBB extended the pool of HLA phenotypes 
      through the generation of unique virtual phenotypes (VPs). A "VP database" was 
      set up, using Microsoft Office-Access, in order to provide NIMA-matched CBUs for 
      potential recipients. The effectiveness of VPs' matching was tested in 80 Greek 
      patients. CONCLUSION: This methodology may contribute to the increase of the 
      number of available CBUs for patients, in the case where there is no available 
      CBU, or in case an additional one is needed. Through this method, the CBUs could 
      be used faster and more effectively, rather than being cryostored for long 
      periods of time.
FAU - Panagouli, Effrosyni
AU  - Panagouli E
AD  - Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, 4 
      Soranou Ephessiou Street, 11527 Athens, Greece. epanagouli@bioacademy.gr.
FAU - Dinou, Amalia
AU  - Dinou A
AD  - Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, 4 
      Soranou Ephessiou Street, 11527 Athens, Greece. adinou@bioacademy.gr.
FAU - Mallis, Panagiotis
AU  - Mallis P
AUID- ORCID: 0000-0001-9429-190X
AD  - Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, 4 
      Soranou Ephessiou Street, 11527 Athens, Greece. pmallis@bioacademy.gr.
FAU - Michalopoulos, Efstathios
AU  - Michalopoulos E
AUID- ORCID: 0000-0002-1901-6294
AD  - Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, 4 
      Soranou Ephessiou Street, 11527 Athens, Greece. smichal@bioacademy.gr.
FAU - Papassavas, Andreas
AU  - Papassavas A
AD  - Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, 4 
      Soranou Ephessiou Street, 11527 Athens, Greece. andreas.papasavvas@yahoo.com.
FAU - Spyropoulou-Vlachou, Maria
AU  - Spyropoulou-Vlachou M
AD  - Immunology Division, General Hospital of Athens "Alexandra", Lourou Street, 11528 
      Athens, Greece. marilynspy@yahoo.gr.
FAU - Meletis, John
AU  - Meletis J
AD  - Department of Hematology and Bone Marrow Transplantation, School of Medicine, 
      National and Kapodistrian University of Athens, 17, Agiou Thoma Street, 11527 
      Athens, Greece. imeletis@med.uoa.gr.
FAU - Angelopoulou, Maria
AU  - Angelopoulou M
AD  - Department of Hematology and Bone Marrow Transplantation, School of Medicine, 
      National and Kapodistrian University of Athens, 17, Agiou Thoma Street, 11527 
      Athens, Greece. mkangelop@gmail.com.
FAU - Konstantopoulos, Kostas
AU  - Konstantopoulos K
AD  - Department of Hematology and Bone Marrow Transplantation, School of Medicine, 
      National and Kapodistrian University of Athens, 17, Agiou Thoma Street, 11527 
      Athens, Greece. kkonstan@med.uoa.gr.
FAU - Vassilakopoulos, Theodoros
AU  - Vassilakopoulos T
AD  - Department of Hematology and Bone Marrow Transplantation, School of Medicine, 
      National and Kapodistrian University of Athens, 17, Agiou Thoma Street, 11527 
      Athens, Greece. theopvass@hotmail.com.
FAU - Stavropoulos-Giokas, Catherine
AU  - Stavropoulos-Giokas C
AD  - Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, 4 
      Soranou Ephessiou Street, 11527 Athens, Greece. cstavrop@bioacademy.gr.
LA  - eng
PT  - Journal Article
DEP - 20180921
PL  - Switzerland
TA  - Bioengineering (Basel)
JT  - Bioengineering (Basel, Switzerland)
JID - 101676056
PMC - PMC6316301
OTO - NOTNLM
OT  - CBU transplantation
OT  - Hellenic Cord Blood Bank
OT  - NIMA
OT  - cord blood
COIS- The authors declare no conflict of interest.
EDAT- 2018/09/27 06:00
MHDA- 2018/09/27 06:01
PMCR- 2018/09/21
CRDT- 2018/09/26 06:00
PHST- 2018/08/10 00:00 [received]
PHST- 2018/09/13 00:00 [revised]
PHST- 2018/09/19 00:00 [accepted]
PHST- 2018/09/26 06:00 [entrez]
PHST- 2018/09/27 06:00 [pubmed]
PHST- 2018/09/27 06:01 [medline]
PHST- 2018/09/21 00:00 [pmc-release]
AID - bioengineering5040077 [pii]
AID - bioengineering-05-00077 [pii]
AID - 10.3390/bioengineering5040077 [doi]
PST - epublish
SO  - Bioengineering (Basel). 2018 Sep 21;5(4):77. doi: 10.3390/bioengineering5040077.