PMID- 30249242
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1746-6148 (Electronic)
IS  - 1746-6148 (Linking)
VI  - 14
IP  - 1
DP  - 2018 Sep 24
TI  - Comparative single-dose pharmacokinetics of sildenafil after oral and rectal 
      administration in healthy beagle dogs.
PG  - 291
LID - 10.1186/s12917-018-1617-7 [doi]
LID - 291
AB  - BACKGROUND: Sildenafil citrate, a highly selective phosphodiesterase type 5 
      inhibitor, is used to treat pulmonary hypertension (PH) in veterinary medicine. 
      The objective of this study was to investigate pharmacokinetic profiles by oral 
      administration of orally disintegrating film (ODF) and film coated tablet (FCT) 
      formulations and rectal administration of ODF formulation in healthy dogs. Twelve 
      healthy beagle dogs were administered four separate doses of sildenafil: FCT 
      formulation 2 mg/kg orally, ODF formulation 2 mg/kg orally, ODF formulation 
      2 mg/kg rectally, and ODF formulation 10 mg/kg rectally. For 24 hours following 
      administration, blood samples were collected and the plasma concentrations of 
      sildenafil were assayed by liquid chromatography-tandem mass spectrometry. 
      RESULTS: There were no significant differences in all the pharmacokinetic 
      parameters between FCT and ODF formulations when administrated orally. C(max) at 
      the time of rectal administration was lower when the same dose was given as that 
      orally administered. No serious systemic adverse events (AEs) were observed. 
      CONCLUSIONS: These findings suggest that sildenafil ODF formulation can be used 
      as an alternative to FCT formulation in the treatment of canine PH patients; 
      additionally, rectal administration of sildenafil ODF may be a beneficial 
      treatment option for canine patients who are unable to receive medication orally.
FAU - Yang, Hyuck-Joo
AU  - Yang HJ
AD  - Department of Veterinary Internal Medicine, College of Veterinary Medicine, 
      Chungnam National University, Daejeon, 34134, Republic of Korea.
FAU - Oh, Ye-In
AU  - Oh YI
AD  - Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul 
      National University, Seoul, 08826, Republic of Korea.
FAU - Jeong, Jong-Woo
AU  - Jeong JW
AD  - Graduate School of New Drug Discovery and Development, Chungnam National 
      University, Daejeon, 34134, Republic of Korea.
FAU - Song, Kun-Ho
AU  - Song KH
AD  - Department of Veterinary Internal Medicine, College of Veterinary Medicine, 
      Chungnam National University, Daejeon, 34134, Republic of Korea.
FAU - Koo, Tae-Sung
AU  - Koo TS
AD  - Graduate School of New Drug Discovery and Development, Chungnam National 
      University, Daejeon, 34134, Republic of Korea. kootae@cnu.ac.kr.
FAU - Seo, Kyoung-Won
AU  - Seo KW
AUID- ORCID: 0000-0002-1561-3278
AD  - Department of Veterinary Internal Medicine, College of Veterinary Medicine, 
      Chungnam National University, Daejeon, 34134, Republic of Korea. kwseo@cnu.ac.kr.
LA  - eng
GR  - 2017M3A9C8021844/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20180924
PL  - England
TA  - BMC Vet Res
JT  - BMC veterinary research
JID - 101249759
RN  - 0 (Phosphodiesterase 5 Inhibitors)
RN  - 0 (Tablets)
RN  - BW9B0ZE037 (Sildenafil Citrate)
SB  - IM
MH  - Administration, Oral
MH  - Administration, Rectal
MH  - Animals
MH  - Area Under Curve
MH  - Cross-Over Studies
MH  - Dogs/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Male
MH  - Phosphodiesterase 5 Inhibitors/administration & dosage/*pharmacokinetics
MH  - Sildenafil Citrate/administration & dosage/*pharmacokinetics
MH  - Tablets
PMC - PMC6154896
OTO - NOTNLM
OT  - Dog
OT  - Orally disintegrating film formulation
OT  - Pulmonary hypertension
OT  - Rectal administration
OT  - Sildenafil
COIS- COMPETING INTEREST: The authors declare that they have no competing interests. 
      ETHICS APPROVAL AND CONSENT TO PARTICIPATE: All animal procedures undertaken were 
      approved by Institutional Animal Care and Use Committee (IACUC) at Chungnam 
      National University (approval number, CNU-00749). CONSENT FOR PUBLICATION: Not 
      applicable. PUBLISHER'S NOTE: Springer Nature remains neutral with regard to 
      jurisdictional claims in published maps and institutional affiliations.
EDAT- 2018/09/27 06:00
MHDA- 2018/12/12 06:00
PMCR- 2018/09/24
CRDT- 2018/09/26 06:00
PHST- 2018/05/06 00:00 [received]
PHST- 2018/09/16 00:00 [accepted]
PHST- 2018/09/26 06:00 [entrez]
PHST- 2018/09/27 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/09/24 00:00 [pmc-release]
AID - 10.1186/s12917-018-1617-7 [pii]
AID - 1617 [pii]
AID - 10.1186/s12917-018-1617-7 [doi]
PST - epublish
SO  - BMC Vet Res. 2018 Sep 24;14(1):291. doi: 10.1186/s12917-018-1617-7.