PMID- 30249627
OWN - NLM
STAT- MEDLINE
DCOM- 20191125
LR  - 20191125
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 8
IP  - 9
DP  - 2018 Sep 24
TI  - Prevalence of depression in patients with type 2 diabetes mellitus in Spain (the 
      DIADEMA Study) : results from the MADIABETES cohort.
PG  - e020768
LID - 10.1136/bmjopen-2017-020768 [doi]
LID - e020768
AB  - OBJECTIVE: To estimate the prevalence of depression in patients diagnosed with 
      type 2 diabetes mellitus (T2DM), and to identify sociodemographic, clinical and 
      psychological factors associated with depression in this population. 
      Additionally, we examine the annual incidence rate of depression among patients 
      with T2DM. METHODS: We performed a large prospective cohort study of patients 
      with T2DM from the Madrid Diabetes Study. The first recruitment drive included 
      3443 patients. The second recruitment drive included 727 new patients. Data have 
      been collected since 2007 (baseline visit) and annually during the follow-up 
      period (since 2008). RESULTS: Depression was prevalent in 20.03% of patients 
      (n=592; 95% CI 18.6% to 21.5%) and was associated with previous personal history 
      of depression (OR 6.482; 95% CI 5.138 to 8.178), mental health status below mean 
      (OR 1.423; 95% CI 1.452 to 2.577), neuropathy (OR 1.951; 95% CI 1.423 to 2.674), 
      fair or poor self-reported health status (OR 1.509; 95% CI 1.209 to 1.882), 
      treatment with oral antidiabetic agents plus insulin (OR 1.802; 95% CI 1.364 to 
      2.380), female gender (OR 1.333; 95% CI 1.009 to 1.761) and blood cholesterol 
      level (OR 1.005; 95% CI 1.002 to 1.009). The variables inversely associated with 
      depression were: being in employment (OR 0.595; 95% CI 0.397 to 0.894), low 
      physical activity (OR 0.552; 95% CI 0.408 to 0.746), systolic blood pressure (OR 
      0.982; 95% CI 0.971 to 0.992) and social support (OR 0.978; 95% CI 0.963 to 
      0.993). In patients without depression at baseline, the incidence of depression 
      after 1 year of follow-up was 1.20% (95% CI 1.11% to 2.81%). CONCLUSIONS: 
      Depression is very prevalent among patients with T2DM and is associated with 
      several key diabetes-related outcomes. Our results suggest that previous mental 
      status, self-reported health status, gender and several diabetes-related 
      complications are associated with differences in the degree of depression. These 
      findings should alert practitioners to the importance of detecting depression in 
      patients with T2DM.
CI  - (c) Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Salinero-Fort, Miguel Angel
AU  - Salinero-Fort MA
AD  - Subdireccion General de Investigacion Sanitaria, Consejeria de Sanidad, Madrid, 
      Spain.
AD  - Nodo Madrid, Red de Investigacion en Servicios de Salud en Enfermedades Cronicas 
      (REDISSEC), Madrid, Spain.
FAU - Gomez-Campelo, P
AU  - Gomez-Campelo P
AD  - Grupo Respuesta Inmune Innata. Hospital La Paz Institute for Health Research 
      (IdiPAZ), La Paz University Hospital, Madrid, Spain.
AD  - Centro de Ciencias de la Salud San Rafael, Universidad Antonio de Nebrija, 
      Madrid, Spain.
FAU - San Andres-Rebollo, F Javier
AU  - San Andres-Rebollo FJ
AD  - Centro de Salud Las Calesas, Servicio Madrileno de Salud, Madrid, Spain.
FAU - Cardenas-Valladolid, Juan
AU  - Cardenas-Valladolid J
AD  - Gerencia Adjunta de Planificacion y Calidad, Gerencia de Atencion Primaria, 
      Servicio Madrileno de Salud, Madrid, Spain.
FAU - Abanades-Herranz, Juan C
AU  - Abanades-Herranz JC
AD  - Centro de Salud Monovar, Sevicio Madrileno de Salud, Madrid, Spain.
FAU - Carrillo de Santa Pau, Enrique
AU  - Carrillo de Santa Pau E
AD  - Grupo de Biologia Computacional, Instituto Madrileno de Estudios Avanzados-IMDEA, 
      Madrid, Spain.
FAU - Chico-Moraleja, Rosa M
AU  - Chico-Moraleja RM
AD  - Servicio de Ortopedia y Traumatologia, Hospital Central de la Defensa, Madrid, 
      Spain.
FAU - Beamud-Victoria, Domingo
AU  - Beamud-Victoria D
AD  - Centro de Salud Felipe II, Madrid, Spain.
FAU - de Miguel-Yanes, Jose M
AU  - de Miguel-Yanes JM
AD  - Servicio de Medicina Interna, Hospital Gregorio Maranon, Madrid, Spain.
FAU - Jimenez-Garcia, Rodrigo
AU  - Jimenez-Garcia R
AD  - Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Alcorcon, Madrid, 
      Spain.
FAU - Lopez-de-Andres, Ana
AU  - Lopez-de-Andres A
AD  - Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Alcorcon, Madrid, 
      Spain.
FAU - Ramallo-Farina, Yolanda
AU  - Ramallo-Farina Y
AD  - Nodo Madrid, Red de Investigacion en Servicios de Salud en Enfermedades Cronicas 
      (REDISSEC), Madrid, Spain.
FAU - De Burgos-Lunar, Carmen
AU  - De Burgos-Lunar C
AD  - Nodo Madrid, Red de Investigacion en Servicios de Salud en Enfermedades Cronicas 
      (REDISSEC), Madrid, Spain.
AD  - Servicio de Medicina Preventiva, Hospital Clinico San Carlos, Madrid, Spain.
CN  - MADIABETES Research Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180924
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Depression/*epidemiology/psychology
MH  - Diabetes Mellitus, Type 2/drug therapy/*epidemiology/psychology
MH  - Diabetic Nephropathies/epidemiology
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Mental Disorders/epidemiology
MH  - Middle Aged
MH  - Prevalence
MH  - Prospective Studies
MH  - Protective Factors
MH  - Risk Factors
MH  - Sex Factors
MH  - Spain/epidemiology
PMC - PMC6157517
OTO - NOTNLM
OT  - cohort studies
OT  - depression
OT  - diabetes mellitus, type 2
OT  - self-care
COIS- Competing interests: None declared.
FIR - Am, Sobrado-de
IR  - Am SD
FIR - Sanz-Pascual, Mar
IR  - Sanz-Pascual M
FIR - Arnalte-Barrera, M
IR  - Arnalte-Barrera M
FIR - Pulido-Fernandez, S
IR  - Pulido-Fernandez S
FIR - Donaire-Jimenez, E M
IR  - Donaire-Jimenez EM
FIR - Montero-Lizana, C
IR  - Montero-Lizana C
FIR - Dominguez-Paniagua, M
IR  - Dominguez-Paniagua M
FIR - Serrano-Simarro, P
IR  - Serrano-Simarro P
FIR - Nicolas, R Echegoyen-de
IR  - Nicolas RE
FIR - Gil-Diaz, P
IR  - Gil-Diaz P
FIR - Cerrada-Somolinos, I
IR  - Cerrada-Somolinos I
FIR - Martin-Cano, R
IR  - Martin-Cano R
FIR - Cava-Rosado, A
IR  - Cava-Rosado A
FIR - Mesonero-Grandes, T
IR  - Mesonero-Grandes T
FIR - Gomez-Navarro, E
IR  - Gomez-Navarro E
FIR - Maestro-Martin, A
IR  - Maestro-Martin A
FIR - Munoz-Cildoz, A
IR  - Munoz-Cildoz A
FIR - Calonge-Garcia, Me
IR  - Calonge-Garcia M
FIR - Martin-Bun, M
IR  - Martin-Bun M
FIR - Carreno-Freire, P
IR  - Carreno-Freire P
FIR - Fernandez-Garcia, J
IR  - Fernandez-Garcia J
FIR - Moran-Escudero, A
IR  - Moran-Escudero A
FIR - Martinez-Irazusta, J
IR  - Martinez-Irazusta J
FIR - Calvo-Garcia, E
IR  - Calvo-Garcia E
FIR - Alayeto-Sanchez, A M
IR  - Alayeto-Sanchez AM
FIR - Reyes-Madridejos, C
IR  - Reyes-Madridejos C
FIR - Bedoya-Frutos, Mj
IR  - Bedoya-Frutos M
FIR - Lopez-Sabater, B
IR  - Lopez-Sabater B
FIR - Innerarity-Martinez, J
IR  - Innerarity-Martinez J
FIR - Rosillo-Gonzalez, A
IR  - Rosillo-Gonzalez A
FIR - Menendez-Fernandez, Ai
IR  - Menendez-Fernandez A
FIR - Mata-Benjumea, F
IR  - Mata-Benjumea F
FIR - Vich-Perez, P
IR  - Vich-Perez P
FIR - Martin-Madrazo, C
IR  - Martin-Madrazo C
FIR - Gomara-Martinez, Mj
IR  - Gomara-Martinez M
FIR - Bello-Gonzalez, C
IR  - Bello-Gonzalez C
FIR - Pinilla-Carrasco, A
IR  - Pinilla-Carrasco A
FIR - Camarero-Shelly, M
IR  - Camarero-Shelly M
FIR - Cano-Espin, A
IR  - Cano-Espin A
FIR - Martin, J Castro
IR  - Martin JC
FIR - Llama-Arauz, B De
IR  - Llama-Arauz B
FIR - Miguel-Ballano, A De
IR  - Miguel-Ballano A
FIR - Garcia-Alonso, Ma
IR  - Garcia-Alonso M
FIR - Garcia-Pascual, J N
IR  - Garcia-Pascual JN
FIR - Gonzalez-Garcia, M I
IR  - Gonzalez-Garcia MI
FIR - Lopez-Rodriguez, C
IR  - Lopez-Rodriguez C
FIR - Miguel-Garzon, M
IR  - Miguel-Garzon M
FIR - Montero-Garcia, M C
IR  - Montero-Garcia MC
FIR - Munoz-Quiros-Aliaga, S
IR  - Munoz-Quiros-Aliaga S
FIR - Nunez-Palomo, S
IR  - Nunez-Palomo S
FIR - Olmos-Carrasco, O
IR  - Olmos-Carrasco O
FIR - Pertierra-Galindo, N
IR  - Pertierra-Galindo N
FIR - Reviriego-Jaen, G
IR  - Reviriego-Jaen G
FIR - Rius-Fortea, P
IR  - Rius-Fortea P
FIR - Rodriguez-Castro, G
IR  - Rodriguez-Castro G
FIR - Vicente-Rodriguez, Jm San
IR  - Vicente-Rodriguez JS
FIR - Serrano-Serrano, M E
IR  - Serrano-Serrano ME
FIR - Zamora-Gomez, M M
IR  - Zamora-Gomez MM
FIR - Zazo-Lazaro, M P
IR  - Zazo-Lazaro MP
EDAT- 2018/09/27 06:00
MHDA- 2019/11/26 06:00
PMCR- 2018/09/24
CRDT- 2018/09/26 06:00
PHST- 2018/09/26 06:00 [entrez]
PHST- 2018/09/27 06:00 [pubmed]
PHST- 2019/11/26 06:00 [medline]
PHST- 2018/09/24 00:00 [pmc-release]
AID - bmjopen-2017-020768 [pii]
AID - 10.1136/bmjopen-2017-020768 [doi]
PST - epublish
SO  - BMJ Open. 2018 Sep 24;8(9):e020768. doi: 10.1136/bmjopen-2017-020768.