PMID- 30250482
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210410
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 9
DP  - 2018
TI  - mTOR Signaling, Translational Control, and the Circadian Clock.
PG  - 367
LID - 10.3389/fgene.2018.00367 [doi]
LID - 367
AB  - Almost all cellular processes are regulated by the approximately 24 h rhythms 
      that are endogenously driven by the circadian clock. mRNA translation, as the 
      most energy consuming step in gene expression, is temporally controlled by 
      circadian rhythms. Recent research has uncovered key mechanisms of translational 
      control that are orchestrated by circadian rhythmicity and in turn feed back to 
      the clock machinery to maintain robustness and accuracy of circadian timekeeping. 
      Here I review recent progress in our understanding of translation control 
      mechanisms in the circadian clock, focusing on a role for the 
      mammalian/mechanistic target of rapamycin (mTOR) signaling pathway in modulating 
      entrainment, synchronization and autonomous oscillation of circadian clocks. I 
      also discuss the relevance of circadian mTOR functions in disease.
FAU - Cao, Ruifeng
AU  - Cao R
AD  - Department of Biomedical Sciences, University of Minnesota Medical School, 
      Duluth, MN, United States.
AD  - Department of Neuroscience, University of Minnesota Medical School, Minneapolis, 
      MN, United States.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180910
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC6139299
OTO - NOTNLM
OT  - SCN
OT  - circadian clock
OT  - entrainment
OT  - mRNA
OT  - mTOR
OT  - oscillation
OT  - synchronization
OT  - translational control
EDAT- 2018/09/27 06:00
MHDA- 2018/09/27 06:01
PMCR- 2018/09/10
CRDT- 2018/09/26 06:00
PHST- 2018/06/25 00:00 [received]
PHST- 2018/08/22 00:00 [accepted]
PHST- 2018/09/26 06:00 [entrez]
PHST- 2018/09/27 06:00 [pubmed]
PHST- 2018/09/27 06:01 [medline]
PHST- 2018/09/10 00:00 [pmc-release]
AID - 10.3389/fgene.2018.00367 [doi]
PST - epublish
SO  - Front Genet. 2018 Sep 10;9:367. doi: 10.3389/fgene.2018.00367. eCollection 2018.