PMID- 30250575
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 16
IP  - 4
DP  - 2018 Oct
TI  - MicroRNA-153 suppresses human laryngeal squamous cell carcinoma migration and 
      invasion by targeting the SNAI1 gene.
PG  - 5075-5083
LID - 10.3892/ol.2018.9302 [doi]
AB  - Human laryngeal squamous cell carcinoma (LSCC) is a malignant cancer type. 
      Epithelial-mesenchymal transition marker Snail family transcriptional repressor 1 
      (SNAI1) is associated with the occurrence, development, invasion and metastasis 
      of numerous tumor types, such as lung, liver and ovarian cancer. Previous studies 
      have indicated that microRNA-153 (miR-153) may serve as a novel tumor suppressor, 
      which is involved in tumor metastasis; however, the role and clinical 
      significance of miR-153 in LSCC are not fully understood. The aim of the present 
      study was to determine the role of miR-153 in the growth and aggressiveness of 
      LSCC cells. Bioinformatics prediction method, western blot analysis, Matrigel 
      invasion assay and immunofluorescence were used to analyze whether SNAI1 can be 
      regulated and controlled by miR-153 in LSCC cells. An inverse association between 
      miR-153 and SNAI1 was observed in LSCC tissues. It was demonstrated that SNAI1 is 
      a direct target of miR-153 in LSCC. In addition, the results indicated that 
      miR-153 knockdown inhibited PCI-13 cell migration and invasion by targeting 
      SNAI1, which may be a potential marker that can reflect the degree of malignancy 
      in patients with LSCC. Furthermore, miR-153 knockdown decreased Twist family BHLH 
      transcription factor 1 and metastasis-associated 1 family member 3 expression in 
      LSCC cells. In conclusion, these data indicated that miR-153 regulates LSCC 
      migration via the targeting of SNAI1 gene, which may be a potential predictor for 
      patients with LSCC.
FAU - Zhang, Binbin
AU  - Zhang B
AD  - Department of Otorhinolaryngology and Maxillofacial Oncology, Tianjin Medical 
      University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and 
      Therapy, Tianjin 300060, P.R. China.
FAU - Fu, Tao
AU  - Fu T
AD  - Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin 300060, P.R. China.
FAU - Zhang, Lun
AU  - Zhang L
AD  - Department of Otorhinolaryngology and Maxillofacial Oncology, Tianjin Medical 
      University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and 
      Therapy, Tianjin 300060, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20180813
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC6144539
OTO - NOTNLM
OT  - Snail family transcriptional repressor 1
OT  - invasion
OT  - laryngeal squamous cell carcinoma
OT  - microRNA-153
OT  - migration
EDAT- 2018/09/27 06:00
MHDA- 2018/09/27 06:01
PMCR- 2018/08/13
CRDT- 2018/09/26 06:00
PHST- 2017/10/19 00:00 [received]
PHST- 2018/05/09 00:00 [accepted]
PHST- 2018/09/26 06:00 [entrez]
PHST- 2018/09/27 06:00 [pubmed]
PHST- 2018/09/27 06:01 [medline]
PHST- 2018/08/13 00:00 [pmc-release]
AID - OL-0-0-9302 [pii]
AID - 10.3892/ol.2018.9302 [doi]
PST - ppublish
SO  - Oncol Lett. 2018 Oct;16(4):5075-5083. doi: 10.3892/ol.2018.9302. Epub 2018 Aug 
      13.