PMID- 30251503
OWN - NLM
STAT- MEDLINE
DCOM- 20181018
LR  - 20181018
IS  - 1872-2059 (Electronic)
IS  - 1000-8713 (Linking)
VI  - 36
IP  - 8
DP  - 2018 Aug 8
TI  - [Determination of 16 phthalate acid esters in infant formula by gas 
      chromatography-tandem mass spectrometry].
PG  - 786-794
LID - 10.3724/SP.J.1123.2018.03010 [doi]
AB  - A method was established for the determination of 16 phthalate acid esters (PAEs) 
      in infant formula by gas chromatography-tandem mass spectrometry (GC-MS/MS). PAEs 
      in infant formula samples were homogenized by deionized water, extracted with 
      acetonitrile, and purified by a solid-phase extraction (SPE) method using primary 
      secondary amine (PSA) sorbents. The separation was performed on a DB-5 MS UI (30 
      mx0.25 mmx0.25 mum) capillary column. Effects of different elution solvents on 
      alumina/PSA and PSA SPE columns were investigated. Fair recoveries of 16 PAEs 
      were achieved on the PSA column upon elution by mixed n-hexane-acetone (60:40, 
      v/v). All the 16 PAEs were quantified by matrix-matched isotopic-dilution mass 
      spectrometry (IDMS); the 16 PAEs showed linear relationships in the concentration 
      range of 0.01-2.0 mg/kg with linear coefficients (R(2)) greater than 0.9996. The 
      limits of detection (LODs) and quantification (LOQs) were in the range of 
      0.15-2.5 mug/kg and 0.50-8.33 mug/kg, respectively. The recoveries of the 16 PAEs, 
      obtained using the IDMS method, were 96.1%-104.0% with relative standard 
      deviations (RSDs) lower than 3.3% (n=5). These results established the method 
      described here as sensitive and precise for the simultaneous determination of 16 
      PAEs in infant formula, even at trace concentrations.
FAU - Xu, Bingbing
AU  - Xu B
AD  - School of Environmental and Municipal Engineering, Xi'an University of 
      Architecture & Technology, Xi'an 710055, China.
AD  - Division of Chemical Metrology and Analytical Science, National Institute of 
      Metrology, Beijing 100029, China.
FAU - Li, Xiaomin
AU  - Li X
AD  - Division of Chemical Metrology and Analytical Science, National Institute of 
      Metrology, Beijing 100029, China.
FAU - Zhang, Qinghe
AU  - Zhang Q
AD  - Division of Chemical Metrology and Analytical Science, National Institute of 
      Metrology, Beijing 100029, China.
FAU - Zhu, Weihuang
AU  - Zhu W
AD  - School of Environmental and Municipal Engineering, Xi'an University of 
      Architecture & Technology, Xi'an 710055, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Esters)
RN  - 0 (Phthalic Acids)
RN  - 6O7F7IX66E (phthalic acid)
SB  - IM
MH  - Esters/*analysis
MH  - Food Contamination/*analysis
MH  - Gas Chromatography-Mass Spectrometry
MH  - Infant Formula/*analysis
MH  - Limit of Detection
MH  - Phthalic Acids/*analysis
MH  - Solid Phase Extraction
MH  - Tandem Mass Spectrometry
OTO - NOTNLM
OT  - gas chromatography-tandem mass spectrometry (GC-MS/MS)
OT  - infant formula
OT  - isotopic-dilution mass spectrometry (IDMS)
OT  - phthalate acid esters (PAEs)
OT  - solid-phase extraction (SPE)
EDAT- 2018/09/27 06:00
MHDA- 2018/10/20 06:00
CRDT- 2018/09/26 06:00
PHST- 2018/09/26 06:00 [entrez]
PHST- 2018/09/27 06:00 [pubmed]
PHST- 2018/10/20 06:00 [medline]
AID - 10.3724/SP.J.1123.2018.03010 [doi]
PST - ppublish
SO  - Se Pu. 2018 Aug 8;36(8):786-794. doi: 10.3724/SP.J.1123.2018.03010.