PMID- 30251517
OWN - NLM
STAT- MEDLINE
DCOM- 20181029
LR  - 20181029
IS  - 1872-2059 (Electronic)
IS  - 1000-8713 (Linking)
VI  - 36
IP  - 9
DP  - 2018 Sep 8
TI  - [Simultaneous rapid determination of 12 anti-allergic chemical drugs in Chinese 
      traditional patent medicine and health food by supercritical fluid chromatography 
      tandem mass spectrometry with solid phase extraction].
PG  - 889-894
LID - 10.3724/SP.J.1123.2018.04006 [doi]
AB  - An analytical method was developed for simultaneous rapid determination of 12 
      anti-allergic chemical drugs in Chinese traditional patent medicine and health 
      food by supercritical fluid chromatography tandem mass spectrometry with solid 
      phase extraction (SPE-SFC-MS/MS). Samples were extracted with methanol by 
      sonification and then purified by Oasis mixed-model cation exchange SPE. The 
      extracts were separated on a Waters Trefoil CEL1 (150 mmx3.0 mm, 2.5 mu m) column 
      with a mobile phase consisting of carbon dioxide-methanol containing 0.1% (v/v) 
      ammonia water in a gradient elution mode, at a flow rate of 1.2 mL/min. The 
      column temperature was 45℃ and the back pressure was 12.4x10(6) Pa. The whole 
      analysis was completed in 10 min. The 12 anti-allergic chemical drugs were 
      detected by an electrospray ion source in positive or negative modes with a 
      multiple reaction monitoring (MRM) mode. The calibration curves of the 12 
      anti-allergic chemical drugs showed good linearities in the range of 5-250 mu g/L 
      with the correlation coefficients (r) >/= 0.998. The limits of detection (LODs) 
      were 0.141-0.262 mu g/L, and the limits of quantification (LOQs) were 0.703-1.308 
      mu g/L. The recoveries of the 12 anti-allergic chemical drugs at spiked levels of 
      10, 20 and 100 mu g/L were in the range of 76.1%-112.5%, and the relative standard 
      deviations (RSDs) were 1.1%-8.3% (n=6). The method is simple, sensitive and 
      reliable. It has been successfully used for the detection of illegally added 
      anti-allergic chemical drugs in Chinese traditional patent medicine and health 
      food.
FAU - Yang, Zhi
AU  - Yang Z
AD  - Hangzhou Institute for Food and Drug Control, Hangzhou 310022, China.
FAU - Peng, Yan
AU  - Peng Y
AD  - Hangzhou Institute for Food and Drug Control, Hangzhou 310022, China.
FAU - Jin, Mengna
AU  - Jin M
AD  - Hangzhou Institute for Food and Drug Control, Hangzhou 310022, China.
FAU - Lin, Liqin
AU  - Lin L
AD  - Hangzhou Institute for Food and Drug Control, Hangzhou 310022, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Anti-Allergic Agents/*analysis
MH  - Chromatography, High Pressure Liquid
MH  - Chromatography, Supercritical Fluid
MH  - Drugs, Chinese Herbal/*analysis
MH  - Limit of Detection
MH  - Medicine, Chinese Traditional
MH  - Solid Phase Extraction
MH  - Tandem Mass Spectrometry
OTO - NOTNLM
OT  - Chinese traditional patent medicine
OT  - anti-allergic chemical drug
OT  - health food
OT  - mass spectrometry (MS)
OT  - solid phase extraction (SPE)
OT  - supercritical fluid chromatography (SFC)
EDAT- 2018/09/27 06:00
MHDA- 2018/10/30 06:00
CRDT- 2018/09/26 06:00
PHST- 2018/09/26 06:00 [entrez]
PHST- 2018/09/27 06:00 [pubmed]
PHST- 2018/10/30 06:00 [medline]
AID - 10.3724/SP.J.1123.2018.04006 [doi]
PST - ppublish
SO  - Se Pu. 2018 Sep 8;36(9):889-894. doi: 10.3724/SP.J.1123.2018.04006.