PMID- 30251731
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1658-3175 (Electronic)
IS  - 0379-5284 (Print)
IS  - 0379-5284 (Linking)
VI  - 39
IP  - 9
DP  - 2018 Sep
TI  - Relationship between human leukocyte antigen DRB1 and psoriasis in Iraqi 
      patients.
PG  - 886-890
LID - 10.15537/smj.2018.9.23156 [doi]
AB  - OBJECTIVES: To investigate the role of Human leukocyte antigen (HLA) Class II 
      DRB1 in susceptibility to psoriasis in Iraqi patients. METHODS: A cross-sectional 
      comparative study including 40 patients with psoriasis attending the Department 
      of Dermatology, Al-Kindy teaching hospital in Baghdad, Iraq, between September 
      2013-2015. Patient selection was carried out by the dermatologists. Ninety 
      healthy individuals were included in the study. Human leukocyte antigen 
      genotyping was carried out by the sequence specific oligonucleotide (SSO) method 
      using Auto LiPA 48 (Innogenetics, Belgium) in the HLA typing research unit of the 
      Al-Kindy College of Medicine, Baghdad, Iraq. RESULTS: There is an increased 
      frequency of HLA-DRB1*0102, *0306 in psoriatic patients with psoriasis 
      p-values=0.001, confidence interval(CI)=2.492-37.487 and odds ratio(OR)=9.666. 
      Human leukocyte antigen-DRB1*1101 is significantly associated with plaque-type 
      psoriasis with p=0.0434, CI=1.04-1.69, and OR=4.2. Human leukocyte 
      antigen-DRB1*0102 is significantly associated with other types of psoriasis with 
      p=0.018, CI=0.0223-0.701, and OR=0.125. CONCLUSION: Human leukocyte 
      antigen-DRB1*0102 and *0306 are significantly associated with psoriasis. Human 
      leukocyte antigen-DRB1*1101 is significantly associated with plaque-type 
      psoriasis. Human leukocyte antigen-DRB1*0102 is significantly associated with 
      other types of psoriasis rather than plaque-type psoriasis.
FAU - Zalzala, Haider H
AU  - Zalzala HH
AD  - Department of Microbiology & Immunology, HLA Typing Research Unit, Al-kindy 
      College of Medicine, University of Baghdad, Baghdad, Iraq. E-mail. 
      haiderhashim@kmc.uobaghdad.edu.iq.
FAU - Abdullah, Galawish A
AU  - Abdullah GA
FAU - Abbas, Mohammed Y
AU  - Abbas MY
FAU - Mohammedsalih, Hyam R
AU  - Mohammedsalih HR
FAU - Mahdi, Batool M
AU  - Mahdi BM
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DRB1 Chains/blood/genetics/*immunology
MH  - Humans
MH  - Iraq
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Psoriasis/blood/*immunology
MH  - Young Adult
PMC - PMC6201012
EDAT- 2018/09/27 06:00
MHDA- 2018/12/12 06:00
PMCR- 2018/09/01
CRDT- 2018/09/26 06:00
PHST- 2018/09/26 06:00 [entrez]
PHST- 2018/09/27 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/09/01 00:00 [pmc-release]
AID - SaudiMedJ-39-886 [pii]
AID - 10.15537/smj.2018.9.23156 [doi]
PST - ppublish
SO  - Saudi Med J. 2018 Sep;39(9):886-890. doi: 10.15537/smj.2018.9.23156.