PMID- 30251758
OWN - NLM
STAT- MEDLINE
DCOM- 20200407
LR  - 20200613
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 40
IP  - 2
DP  - 2019 Feb 1
TI  - Resting state functional connectivity of networks associated with reward and 
      habit in anorexia nervosa.
PG  - 652-662
LID - 10.1002/hbm.24402 [doi]
AB  - Neurobiological disturbances associated with reward and/or habit learning are 
      theorized to maintain symptoms of anorexia nervosa (AN). Although research has 
      investigated responses in brain regions associated with reward and habit to 
      disorder-specific cues (e.g., food) and presumed rewards (e.g., money), little is 
      known about the functional organization of the circuits underlying these 
      constructs independent of stimulus. This study aimed to provide initial data on 
      the synchrony of networks associated with reward and habit in AN by comparing 
      resting-state functional connectivity (RSFC) patterns between AN and healthy 
      control (HC) participants in these circuits and delineating how these patterns 
      relate to symptoms. Using theoretically selected seeds in the nucleus accumbens 
      (NAcc), ventral caudate, and dorsal caudate, reflecting a continuum from reward- 
      to habit- oriented regions, RSFC patterns were compared between AN restricting 
      subtype (n = 19) and HC (n = 19) participants (cluster threshold: p < .01). 
      Exploratory correlations between RSFC z-scores and Eating Disorder Examination 
      (EDE) scores, BMI, and illness duration were conducted. The AN group demonstrated 
      lower RSFC between the NAcc and superior frontal gyrus, between the ventral 
      caudate and frontal and posterior regions, and between the dorsal caudate and 
      frontal, temporal, and posterior regions. In the AN group, lower NAcc- superior 
      frontal gyrus RSFC correlated with greater EDE Global scores (r = -.58, CI: -.83, 
      -.13). These resting-state synchrony disruptions of the ventral and dorsal 
      frontostriatal circuits, considered in context of the broader literature, support 
      the utility of further investigating possible reward and habit disturbances 
      supporting symptoms in AN.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Haynos, Ann F
AU  - Haynos AF
AUID- ORCID: 0000-0002-2548-1731
AD  - Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota.
FAU - Hall, Leah M J
AU  - Hall LMJ
AD  - Department of Psychology, University of Minnesota, Minneapolis, Minnesota.
AD  - Eastern Oklahoma VA Medical Center, Tulsa, Oklahoma.
FAU - Lavender, Jason M
AU  - Lavender JM
AD  - Department of Psychiatry, University of California, San Diego, California.
FAU - Peterson, Carol B
AU  - Peterson CB
AD  - Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota.
AD  - The Emily Program, St. Paul, Minnesota.
FAU - Crow, Scott J
AU  - Crow SJ
AD  - Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota.
AD  - The Emily Program, St. Paul, Minnesota.
FAU - Klimes-Dougan, Bonnie
AU  - Klimes-Dougan B
AD  - Department of Psychology, University of Minnesota, Minneapolis, Minnesota.
FAU - Cullen, Kathryn R
AU  - Cullen KR
AD  - Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota.
FAU - Lim, Kelvin O
AU  - Lim KO
AD  - Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota.
FAU - Camchong, Jazmin
AU  - Camchong J
AD  - Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota.
LA  - eng
GR  - T32 MH082761/MH/NIMH NIH HHS/United States
GR  - UL1 TR002494/TR/NCATS NIH HHS/United States
GR  - KL2 TR002492/TR/NCATS NIH HHS/United States
GR  - T32MH082761/MH/NIMH NIH HHS/United States
GR  - K23 MH112867/MH/NIMH NIH HHS/United States
GR  - K23MH112867/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20180925
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anorexia Nervosa/diagnostic imaging/*physiopathology
MH  - Caudate Nucleus/diagnostic imaging/*physiopathology
MH  - Cerebral Cortex/diagnostic imaging/*physiopathology
MH  - *Connectome
MH  - Female
MH  - *Habits
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Nerve Net/diagnostic imaging/*physiopathology
MH  - Nucleus Accumbens/diagnostic imaging/*physiopathology
MH  - *Reward
MH  - Young Adult
PMC - PMC6314844
MID - NIHMS1000982
OTO - NOTNLM
OT  - anorexia nervosa
OT  - eating disorder
OT  - functional connectivity
OT  - habit
OT  - resting state fMRI
OT  - reward
EDAT- 2018/09/27 06:00
MHDA- 2020/04/09 06:00
PMCR- 2018/09/25
CRDT- 2018/09/26 06:00
PHST- 2018/01/15 00:00 [received]
PHST- 2018/08/27 00:00 [revised]
PHST- 2018/09/04 00:00 [accepted]
PHST- 2018/09/27 06:00 [pubmed]
PHST- 2020/04/09 06:00 [medline]
PHST- 2018/09/26 06:00 [entrez]
PHST- 2018/09/25 00:00 [pmc-release]
AID - HBM24402 [pii]
AID - 10.1002/hbm.24402 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2019 Feb 1;40(2):652-662. doi: 10.1002/hbm.24402. Epub 2018 Sep 
      25.