PMID- 30253386
OWN - NLM
STAT- MEDLINE
DCOM- 20200601
LR  - 20201214
IS  - 1662-8128 (Electronic)
IS  - 1662-811X (Print)
IS  - 1662-811X (Linking)
VI  - 11
IP  - 3
DP  - 2019
TI  - Cyclic Dimeric Guanosine Monophosphate: Activation and Inhibition of Innate 
      Immune Response.
PG  - 242-248
LID - 10.1159/000492679 [doi]
AB  - Cyclic dimeric guanosine monophosphate (c-di-GMP) is a universally conserved 
      second messenger that contributes to the pathogenicity of numerous bacterial 
      species. In recent years, growing evidence has shown that bacterial extracellular 
      c-di-GMP can interact with the innate immune system and regulate host immune 
      responses. This review summarizes our current understanding on the dual roles of 
      bacterial c-di-GMP in pathogen-host interaction: activation of the antibacterial 
      innate immune response through the cytosolic surveillance pathway and inhibition 
      of innate immune defense for iron restriction.
CI  - (c) 2018 The Author(s) Published by S. Karger AG, Basel.
FAU - Cui, Tao
AU  - Cui T
AD  - School of Life Sciences, Northwestern Polytechnical University, Xi'an, China.
FAU - Cang, Huaixing
AU  - Cang H
AD  - School of Life Sciences, Northwestern Polytechnical University, Xi'an, China.
FAU - Yang, Baoqiang
AU  - Yang B
AD  - School of Life Sciences, Northwestern Polytechnical University, Xi'an, China.
FAU - He, Zheng-Guo
AU  - He ZG
AD  - National Key Laboratory of Agricultural Microbiology, College of Life Science and 
      Technology, Huazhong Agricultural University, Wuhan, China, 
      hezhengguo@mail.hzau.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180925
PL  - Switzerland
TA  - J Innate Immun
JT  - Journal of innate immunity
JID - 101469471
RN  - 0 (LCN2 protein, human)
RN  - 0 (Lipocalin-2)
RN  - 0 (Membrane Proteins)
RN  - 0 (STING1 protein, human)
RN  - 61093-23-0 (bis(3',5')-cyclic diguanylic acid)
RN  - EC 3.6.1.- (DDX41 protein, human)
RN  - EC 3.6.4.13 (DEAD-box RNA Helicases)
RN  - H2D2X058MU (Cyclic GMP)
SB  - IM
MH  - Cyclic GMP/*analogs & derivatives/physiology
MH  - DEAD-box RNA Helicases/physiology
MH  - *Host-Pathogen Interactions
MH  - Humans
MH  - *Immunity, Innate
MH  - Lipocalin-2/physiology
MH  - Membrane Proteins/physiology
PMC - PMC6738221
OTO - NOTNLM
OT  - Cyclic dimeric guanosine monophosphate
OT  - Cytosolic surveillance pathway
OT  - DDX41
OT  - Innate immune defense
OT  - Lipocalin-2
OT  - STING
OT  - Siderocalin
EDAT- 2018/09/27 06:00
MHDA- 2020/06/02 06:00
PMCR- 2018/09/25
CRDT- 2018/09/26 06:00
PHST- 2018/04/14 00:00 [received]
PHST- 2018/08/04 00:00 [accepted]
PHST- 2018/09/27 06:00 [pubmed]
PHST- 2020/06/02 06:00 [medline]
PHST- 2018/09/26 06:00 [entrez]
PHST- 2018/09/25 00:00 [pmc-release]
AID - 000492679 [pii]
AID - jin-0011-0242 [pii]
AID - 10.1159/000492679 [doi]
PST - ppublish
SO  - J Innate Immun. 2019;11(3):242-248. doi: 10.1159/000492679. Epub 2018 Sep 25.