PMID- 30253913
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1575
DP  - 2018 Nov 9
TI  - Magnesium-aluminum-layered double hydroxide-graphene oxide composite mixed-matrix 
      membrane for the thin-film microextraction of diclofenac in biological fluids.
PG  - 11-17
LID - S0021-9673(18)31175-0 [pii]
LID - 10.1016/j.chroma.2018.09.024 [doi]
AB  - Herein, the applicability of Mg-Al-layered double hydroxide-graphene oxide 
      (LDH/GO) mixed-matrix membrane (MMM) for microextraction purposes is reported for 
      the first time. The LDH/GO MMM was used as sorbent for the thin film 
      microextraction (TFME) of diclofenac in human body fluids. The prepared LDH/GO 
      composite has been incorporated into a mechanically stable polyvinylidene 
      difluoride (PVDF) membrane. The contribution of GO in LDH/GO composites 
      significantly improved the extraction efficiency of the TFME sorbent. After 
      elution with methanol, diclofenac was quantified by high performance liquid 
      chromatography-ultraviolet detection (HPLC-UV). Plackett-Burman design was used 
      for screening the experimental factors of interest and specify the significant 
      variables affecting the extraction efficiency. The effective factors were 
      optimized using Box-Behnken design (BBD). Under the optimum conditions, limits of 
      detections (LODs) were 0.14, 0.23 and 0.57 mug L(-1) in water, urine and plasma 
      samples, respectively. Limits of quantifications (LOQs) were 0.46, 0.76 and 
      1.8 mug L(-1) in water, urine and plasma samples, respectively. Relative standard 
      deviations (RSDs) at a spiked concentration of 10 mug L(-1) were 6.7, 6.9 and 7.1% 
      (as intra-day RSD) in water, urine and plasma samples, respectively. The linear 
      dynamic ranges (LDRs) were in the range of 0.5-200 mug L(-1). The applicability of 
      the method was investigated by the extraction and determination of diclofenac in 
      different biological fluids including urine and plasma samples.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Ghani, Milad
AU  - Ghani M
AD  - Department of Analytical Chemistry, Faculty of Chemistry, University of 
      Mazandaran, Babolsar, Iran.
FAU - Ghoreishi, Sayed Mehdi
AU  - Ghoreishi SM
AD  - Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, 
      Kashan, Iran. Electronic address: s.m.ghoreishi@kashanu.ac.ir.
FAU - Azamati, Mostafa
AU  - Azamati M
AD  - Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, 
      Kashan, Iran.
LA  - eng
PT  - Journal Article
DEP - 20180917
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Membranes, Artificial)
RN  - 0 (Oxides)
RN  - 059QF0KO0R (Water)
RN  - 144O8QL0L1 (Diclofenac)
RN  - 7782-42-5 (Graphite)
RN  - CPD4NFA903 (Aluminum)
RN  - I38ZP9992A (Magnesium)
SB  - IM
MH  - Aluminum/chemistry
MH  - Body Fluids/*chemistry
MH  - Chromatography, High Pressure Liquid
MH  - Diclofenac/*isolation & purification
MH  - Graphite/chemistry
MH  - Humans
MH  - Limit of Detection
MH  - Liquid Phase Microextraction/*instrumentation
MH  - Magnesium/chemistry
MH  - *Membranes, Artificial
MH  - Oxides/*chemistry
MH  - Plasma/chemistry
MH  - Urine/chemistry
MH  - Water/chemistry
OTO - NOTNLM
OT  - Biological fluids
OT  - Diclofenac
OT  - Experimental design
OT  - Mg-Al-layered double hydroxide-graphene oxide composite
OT  - Thin film microextraction
EDAT- 2018/09/27 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/09/27 06:00
PHST- 2018/05/24 00:00 [received]
PHST- 2018/09/09 00:00 [revised]
PHST- 2018/09/15 00:00 [accepted]
PHST- 2018/09/27 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/09/27 06:00 [entrez]
AID - S0021-9673(18)31175-0 [pii]
AID - 10.1016/j.chroma.2018.09.024 [doi]
PST - ppublish
SO  - J Chromatogr A. 2018 Nov 9;1575:11-17. doi: 10.1016/j.chroma.2018.09.024. Epub 
      2018 Sep 17.