PMID- 30255014
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2296-2646 (Print)
IS  - 2296-2646 (Electronic)
IS  - 2296-2646 (Linking)
VI  - 6
DP  - 2018
TI  - Cyclodextrin-Based Polymer-Supported Bacterium for the Adsorption and in-situ 
      Biodegradation of Phenolic Compounds.
PG  - 403
LID - 10.3389/fchem.2018.00403 [doi]
LID - 403
AB  - Dual function polymer materials with immobilized Sphingobium Chorophenolicum 
      (SpC) bacterium cells are reported herein that undergo tandem adsorption and 
      biodegradation of phenolic compounds. The cross-linked polymer materials contain 
      beta-cyclodextrin (beta-CD) with incremental hexamethylene diisocyanate (HDI) 
      cross-linker at variable mole ratios (X = 1, 3, or 6), denoted as HDI-X systems. 
      The adsorptive uptake properties of the insoluble HDI-X polymers (X = 3 and 6) 
      with various phenolic compounds [pentachlorophenol (PCP), 2,4,6-trichlorophenol 
      (TCP), and 2,4,6-trimethylphenol (TMP)] were studied using batch adsorption 
      isotherms. The molecular selective phenol removal (S(R)) capacity of the HDI-3 
      and HDI-6 materials was evaluated by electrospray ionization mass spectrometry 
      (ESI-MS). The results were compared against granular activated carbon (GAC) and 
      native beta-CD, where 1D/2D (1)H NMR spectral characterization of the complexes 
      formed between phenolic guests and a soluble polymer (HDI-1) in aqueous solution 
      provide insight on the intermolecular interactions and the role of cross-linking 
      effects. Immobilization of SpC onto HDI-3 was shown to form a composite 
      polymer/bacterium material. The composite system displays synergistic removal 
      effects due to tandem PCP adsorption and SpC biodegradation to yield by-products 
      such as 2,6-dichloro-1,4-hydroquinone (DCHQ). Apoptosis and cytotoxicity of DCHQ 
      were evaluated using three breast cancer cell lines.
FAU - Karoyo, Abdalla H
AU  - Karoyo AH
AD  - Department of Chemistry, University of Saskatchewan, Saskatoon, SK, Canada.
FAU - Yang, Jian
AU  - Yang J
AD  - Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, 
      University of Saskatchewan, Saskatoon, SK, Canada.
FAU - Wilson, Lee D
AU  - Wilson LD
AD  - Department of Chemistry, University of Saskatchewan, Saskatoon, SK, Canada.
LA  - eng
PT  - Journal Article
DEP - 20180911
PL  - Switzerland
TA  - Front Chem
JT  - Frontiers in chemistry
JID - 101627988
PMC - PMC6141685
OTO - NOTNLM
OT  - adsorption
OT  - bacterium immobilization
OT  - biodegradation
OT  - phenolic compounds
OT  - polymer
OT  - beta-cyclodextrin
EDAT- 2018/09/27 06:00
MHDA- 2018/09/27 06:01
PMCR- 2018/01/01
CRDT- 2018/09/27 06:00
PHST- 2018/06/01 00:00 [received]
PHST- 2018/08/20 00:00 [accepted]
PHST- 2018/09/27 06:00 [entrez]
PHST- 2018/09/27 06:00 [pubmed]
PHST- 2018/09/27 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fchem.2018.00403 [doi]
PST - epublish
SO  - Front Chem. 2018 Sep 11;6:403. doi: 10.3389/fchem.2018.00403. eCollection 2018.