PMID- 30257264
OWN - NLM
STAT- MEDLINE
DCOM- 20210215
LR  - 20211204
IS  - 1439-3646 (Electronic)
IS  - 0947-7349 (Linking)
VI  - 128
IP  - 5
DP  - 2020 May
TI  - Angiopoietin-like 8 Improves Insulin Resistance and Attenuates Adipose Tissue 
      Inflammation in Diet-Induced Obese Mice.
PG  - 290-296
LID - 10.1055/a-0725-7897 [doi]
AB  - Angiopoietin-like 8 (ANGPTL8) is closely linked to obesity-associated metabolic 
      diseases and insulin resistance. The aim of the current study was to investigate 
      the ability of ANGPTL8 to reverse insulin resistance in obese mice. The 
      administration of ANGPTL8 reduced weight gain and improved glucose tolerance in 
      mice with diet-induced obesity. In addition, ANGPTL8 administration modified 
      macrophage infiltration, reduced monocyte chemoattractant protein-1 (MCP-1) and 
      interleukin-1beta(IL-1beta) levels, and increased adiponectin gene expression in 
      inguinal white adipose tissue (iWAT). Moreover, the exposure of a cultured 
      peritoneal macrophage line to ANGPTL8 reduced the mRNA expression of M1 
      macrophage markers (TNF-alpha and IL-1beta) upon stimulation with lipopolysaccharides in 
      a dose-dependent manner. By contrast, when incubated with IL-4, exposure of 
      macrophages to ANGPTL8 increased the mRNA expression of M2 macrophage markers 
      (Arg1 and Chi3l3) in a dose-dependent manner. Collectively, the results of the 
      present study demonstrated that treatment with ANGPTL8 can attenuate adipose 
      tissue inflammation through regulation of macrophage polarization, and thus, it 
      could be useful for improving insulin resistance.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Luo, Deng
AU  - Luo D
AD  - Department of Endocrinology, Renmin Hospital, Wuhan University, Wuhan, 430060, 
      China.
FAU - Chen, Xiaolin
AU  - Chen X
AD  - Department of Endocrinology, Renmin Hospital, Wuhan University, Wuhan, 430060, 
      China.
FAU - Yang, Wenqiang
AU  - Yang W
AD  - Department of Clinical Laboratory, Wuhan No. 1 Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, 430023, China.
FAU - Ran, Wenzhuo
AU  - Ran W
AD  - Department of Clinical Laboratory, Wuhan No. 1 Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, 430023, China.
FAU - Wen, Zhongyuan
AU  - Wen Z
AD  - Department of Endocrinology, Renmin Hospital, Wuhan University, Wuhan, 430060, 
      China.
LA  - eng
GR  - Wuhan Science and Technology Bureau/2015061701011619/
GR  - Wuhan University of China/2042017kf0084/
GR  - Natural Science Foundation of Hubei Province/2018CFB230/
PT  - Journal Article
DEP - 20180926
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
RN  - 0 (ANGPTL8 protein, mouse)
RN  - 0 (Angiopoietin-Like Protein 8)
RN  - 0 (Angiopoietin-like Proteins)
SB  - IM
MH  - Adipose Tissue, White/*drug effects
MH  - Angiopoietin-Like Protein 8
MH  - Angiopoietin-like Proteins/*pharmacology
MH  - Animals
MH  - Cell Line
MH  - Diet, High-Fat/adverse effects
MH  - Disease Models, Animal
MH  - Glucose Intolerance/*drug therapy/etiology
MH  - Inflammation/*drug therapy/etiology
MH  - *Insulin Resistance
MH  - Macrophages/*drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Obesity/complications/*drug therapy/etiology
COIS- No conflict of interest has been declared by the authors.
EDAT- 2018/09/27 06:00
MHDA- 2021/02/16 06:00
CRDT- 2018/09/27 06:00
PHST- 2018/09/27 06:00 [pubmed]
PHST- 2021/02/16 06:00 [medline]
PHST- 2018/09/27 06:00 [entrez]
AID - 10.1055/a-0725-7897 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2020 May;128(5):290-296. doi: 10.1055/a-0725-7897. 
      Epub 2018 Sep 26.