PMID- 30257378
OWN - NLM
STAT- MEDLINE
DCOM- 20190103
LR  - 20220409
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 107
DP  - 2018 Nov
TI  - Brachychiton populneus (Schott & Endl.) R.Br. ameliorate carbon tetrachloride 
      induced oxidative stress through regulation of endoplasmic reticulum stress 
      markers and inflammatory mediators in Sprague-Dawley male rats.
PG  - 1601-1610
LID - S0753-3322(18)35132-1 [pii]
LID - 10.1016/j.biopha.2018.09.005 [doi]
AB  - In this study hepatoprotective aptitude of Brachychiton populneus against carbon 
      tetrachloride (CCl(4)) instigated liver injuries in rats was investigated. 
      High-performance liquid chromatography (HPLC) with a diode array detector (DAD) 
      analysis of methanol extract of B. populneus (BPM) indicated existence of rutin, 
      catechin and myricetin. Administration of CCl(4) to rat decreased (p < 0.01) the 
      level of catalase (CAT), total superoxide dismutase (SOD), peroxidase (POD), 
      soluble protein and reduced glutathione (GSH) whereas elevated the concentration 
      of H(2)O(2), thiobarbituric acid reactive substances and nitrite in hepatic 
      samples. In serum the level of hepatic markers; aspartate transaminase, alanine 
      transaminase, alkaline phosphatase and total bilirubin increased with CCl(4) 
      treatment against control animals. In hepatic samples the expression level of 
      endoplasmic reticulum stress associated genes like glucose regulated protein 
      (GRP78), x-box binding protein- 1 total (XBP-1 t), x-box binding protein- 1 
      spliced (XBP-1 s), x-box binding protein- 1 unspliced (XBP-1 u), 
      glutamate-cysteine ligase catalytic subunit (GCLC) and pro-inflammatory 
      cytokines; tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and monocyte 
      chemoattractant protein-1 (MCP-1) was elevated many fold with CCl(4) 
      administration to rat. Co-administration of BPM along with CCl(4) to rats 
      decreased (p < 0.05) the expression of above genes except GCLC where expression 
      level was enhanced as compared to CCl(4) treatment. Histopathology of liver 
      showed injuries of hepatocytes, infiltration of leukocytes and damaged central 
      lobule in CCl(4) treated rats. However, BPM administration to CCl(4) intoxicated 
      rats restored the altered parameters towards the control rats. These results 
      suggested the presence of antioxidant and anti-inflammatory constituents in 
      methanol extract of B. populneus.
CI  - Copyright (c) 2018 Elsevier Masson SAS. All rights reserved.
FAU - Batool, Riffat
AU  - Batool R
AD  - Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam 
      University Islamabad, Islamabad, Pakistan. Electronic address: 
      biochemist60@gmail.com.
FAU - Rashid Khan, Muhammad
AU  - Rashid Khan M
AD  - Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam 
      University Islamabad, Islamabad, Pakistan. Electronic address: 
      mrkhanqau@yahoo.com.
FAU - Ahmed Zai, Jawaid
AU  - Ahmed Zai J
AD  - Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam 
      University Islamabad, Islamabad, Pakistan. Electronic address: 
      jawaidzai@gmail.co.
FAU - Ali, Saima
AU  - Ali S
AD  - Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam 
      University Islamabad, Islamabad, Pakistan. Electronic address: 
      saima.bch@gmail.com.
FAU - Maryam, Sonia
AU  - Maryam S
AD  - Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam 
      University Islamabad, Islamabad, Pakistan. Electronic address: 
      soniamaryam786@gmail.com.
FAU - Naz, Irum
AU  - Naz I
AD  - Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam 
      University Islamabad, Islamabad, Pakistan. Electronic address: 
      irumnazbs@qau.edu.pk.
FAU - Bibi, Saira
AU  - Bibi S
AD  - Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam 
      University Islamabad, Islamabad, Pakistan. Electronic address: 
      sairabibi350@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20180907
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Plant Extracts)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - CL2T97X0V0 (Carbon Tetrachloride)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/isolation & purification/pharmacology
MH  - Antioxidants/isolation & purification/pharmacology
MH  - Carbon Tetrachloride/toxicity
MH  - Chromatography, High Pressure Liquid/methods
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Endoplasmic Reticulum Stress/drug effects
MH  - Gene Expression Regulation/drug effects
MH  - Hepatocytes/drug effects/pathology
MH  - Hydrogen Peroxide/metabolism
MH  - Inflammation Mediators/metabolism
MH  - Liver Diseases/*drug therapy/physiopathology
MH  - Liver Function Tests
MH  - Male
MH  - Malvaceae/*chemistry
MH  - Oxidative Stress/*drug effects
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Thiobarbituric Acid Reactive Substances/metabolism
OTO - NOTNLM
OT  - Anti-Inflammatory
OT  - Antioxidant
OT  - Brachychiton populneus
OT  - ER stress
OT  - TNF-a
EDAT- 2018/09/28 06:00
MHDA- 2019/01/04 06:00
CRDT- 2018/09/28 06:00
PHST- 2018/07/24 00:00 [received]
PHST- 2018/09/03 00:00 [revised]
PHST- 2018/09/03 00:00 [accepted]
PHST- 2018/09/28 06:00 [entrez]
PHST- 2018/09/28 06:00 [pubmed]
PHST- 2019/01/04 06:00 [medline]
AID - S0753-3322(18)35132-1 [pii]
AID - 10.1016/j.biopha.2018.09.005 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2018 Nov;107:1601-1610. doi: 10.1016/j.biopha.2018.09.005. 
      Epub 2018 Sep 7.