PMID- 30257529
OWN - NLM
STAT- MEDLINE
DCOM- 20190111
LR  - 20190111
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 19
IP  - 10
DP  - 2018 Sep 25
TI  - Contribution of Resident Stem Cells to Liver and Biliary Tree Regeneration in 
      Human Diseases.
LID - 10.3390/ijms19102917 [doi]
LID - 2917
AB  - Two distinct stem/progenitor cell populations of biliary origin have been 
      identified in the adult liver and biliary tree. Hepatic Stem/progenitor Cells 
      (HpSCs) are bipotent progenitor cells located within the canals of Hering and can 
      be differentiated into mature hepatocytes and cholangiocytes; Biliary Tree 
      Stem/progenitor Cells (BTSCs) are multipotent stem cells located within the 
      peribiliary glands of large intrahepatic and extrahepatic bile ducts and able to 
      differentiate into hepatic and pancreatic lineages. HpSCs and BTSCs are endowed 
      in a specialized niche constituted by supporting cells and extracellular matrix 
      compounds. The actual contribution of these stem cell niches to liver and biliary 
      tree homeostatic regeneration is marginal; this is due to the high replicative 
      capabilities and plasticity of mature parenchymal cells (i.e., hepatocytes and 
      cholangiocytes). However, the study of human liver and biliary diseases disclosed 
      how these stem cell niches are involved in the regenerative response after 
      extensive and/or chronic injuries, with the activation of specific signaling 
      pathways. The present review summarizes the contribution of stem/progenitor cell 
      niches in human liver diseases, underlining mechanisms of activation and clinical 
      implications, including fibrogenesis and disease progression.
FAU - Overi, Diletta
AU  - Overi D
AD  - Department of Anatomical, Histological, Forensic Medicine and Orthopedics 
      Sciences, Sapienza University of Rome, Via Borelli 50, 00161 Rome, Italy. 
      diletta.overi@uniroma1.it.
FAU - Carpino, Guido
AU  - Carpino G
AD  - Department of Movement, Human and Health Sciences, Division of Health Sciences, 
      University of Rome "Foro Italico", Piazza Lauro de Bosis 6, 00135 Rome, Italy. 
      guido.carpino@uniroma1.it.
FAU - Cardinale, Vincenzo
AU  - Cardinale V
AD  - Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University 
      of Rome, Corso della Repubblica 79, 04100 Latina, Italy. v.cardinale80@gmail.com.
FAU - Franchitto, Antonio
AU  - Franchitto A
AD  - Department of Anatomical, Histological, Forensic Medicine and Orthopedics 
      Sciences, Sapienza University of Rome, Via Borelli 50, 00161 Rome, Italy. 
      antonio.franchitto@uniroma1.it.
FAU - Safarikia, Samira
AU  - Safarikia S
AD  - Department of Internal Medicine and Medical Specialties, Sapienza University of 
      Rome, Viale del Policlinico 151, 00161 Rome, Italy. samira.safarikia@uniroma1.it.
FAU - Onori, Paolo
AU  - Onori P
AUID- ORCID: 0000-0002-7195-3760
AD  - Department of Anatomical, Histological, Forensic Medicine and Orthopedics 
      Sciences, Sapienza University of Rome, Via Borelli 50, 00161 Rome, Italy. 
      paolo.onori@uniroma1.it.
FAU - Alvaro, Domenico
AU  - Alvaro D
AD  - Department of Internal Medicine and Medical Specialties, Sapienza University of 
      Rome, Viale del Policlinico 151, 00161 Rome, Italy. domenico.alvaro@uniroma1.it.
FAU - Gaudio, Eugenio
AU  - Gaudio E
AD  - Department of Anatomical, Histological, Forensic Medicine and Orthopedics 
      Sciences, Sapienza University of Rome, Via Borelli 50, 00161 Rome, Italy. 
      eugenio.gaudio@uniroma1.it.
LA  - eng
GR  - Ateneo/Sapienza Universita di Roma/
GR  - SRA/Vesta Therapeutics/
PT  - Journal Article
PT  - Review
DEP - 20180925
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Animals
MH  - Biliary Tract/*cytology/metabolism/*pathology/physiology
MH  - Biliary Tract Diseases/etiology/metabolism/*pathology
MH  - Disease Progression
MH  - Humans
MH  - Liver/*cytology/metabolism/*pathology/physiology
MH  - Liver Diseases/etiology/metabolism/*pathology
MH  - Liver Regeneration
MH  - Regeneration
MH  - Signal Transduction
MH  - Stem Cell Niche
MH  - Stem Cells/*cytology/metabolism/pathology
PMC - PMC6213374
OTO - NOTNLM
OT  - biliary tree stem/progenitor cells
OT  - cholangiopathies
OT  - ductular reaction
OT  - hepatic stem/progenitor cells
OT  - liver fibrosis
OT  - liver regeneration
OT  - peribiliary glands
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2018/09/28 06:00
MHDA- 2019/01/12 06:00
PMCR- 2018/10/01
CRDT- 2018/09/28 06:00
PHST- 2018/08/29 00:00 [received]
PHST- 2018/09/18 00:00 [revised]
PHST- 2018/09/19 00:00 [accepted]
PHST- 2018/09/28 06:00 [entrez]
PHST- 2018/09/28 06:00 [pubmed]
PHST- 2019/01/12 06:00 [medline]
PHST- 2018/10/01 00:00 [pmc-release]
AID - ijms19102917 [pii]
AID - ijms-19-02917 [pii]
AID - 10.3390/ijms19102917 [doi]
PST - epublish
SO  - Int J Mol Sci. 2018 Sep 25;19(10):2917. doi: 10.3390/ijms19102917.