PMID- 30258091
OWN - NLM
STAT- MEDLINE
DCOM- 20191024
LR  - 20191115
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Sep 26
TI  - Assessing cortical plasticity after spinal cord injury by using resting-state 
      functional magnetic resonance imaging in awake adult mice.
PG  - 14406
LID - 10.1038/s41598-018-32766-8 [doi]
LID - 14406
AB  - Neural connectivity has recently been shown to be altered after spinal cord 
      injury (SCI) not only in the spinal cord but also in the brain. However, to date, 
      no studies have analyzed the functional alterations after SCI in various areas of 
      the cerebral cortex over time. To examine the plasticity of the neural 
      connectivity in the brain after SCI, we performed resting-state functional 
      magnetic resonance imaging (rs-fMRI) in awake adult mice pre- and post-SCI. After 
      a complete thoracic SCI, the functional connectivity between the primary motor 
      (MOp) and primary sensory (SSp) areas was significantly decreased during the 
      chronic phase. In contrast, the connectivity between the MOp and motivation area 
      was increased. Thus, impairments in sensory and motor connections after SCI led 
      to a time-dependent compensatory upregulation of "motor functional motivation". 
      Moreover, the functional connectivity between the SSp and pain-related areas, 
      such as the caudoputamen (CP) and the anterior cingulate area (ACA), was 
      strengthened during the chronic phase, thus suggesting that rs-fMRI can indicate 
      the presence of neuropathic pain after SCI. Therefore, rs-fMRI is a useful tool 
      for revealing the pathological changes that occur in the brain after SCI.
FAU - Matsubayashi, Kohei
AU  - Matsubayashi K
AD  - Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, 
      Japan.
AD  - Department of Physiology, Keio University School of Medicine, Tokyo, Japan.
FAU - Nagoshi, Narihito
AU  - Nagoshi N
AD  - Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, 
      Japan.
FAU - Komaki, Yuji
AU  - Komaki Y
AUID- ORCID: 0000-0002-9793-0938
AD  - Department of Physiology, Keio University School of Medicine, Tokyo, Japan.
AD  - Central Institute for Experimental Animals, Kawasaki, Japan.
FAU - Kojima, Kota
AU  - Kojima K
AD  - Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, 
      Japan.
FAU - Shinozaki, Munehisa
AU  - Shinozaki M
AD  - Department of Physiology, Keio University School of Medicine, Tokyo, Japan.
FAU - Tsuji, Osahiko
AU  - Tsuji O
AD  - Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, 
      Japan.
FAU - Iwanami, Akio
AU  - Iwanami A
AD  - Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, 
      Japan.
FAU - Ishihara, Ryosuke
AU  - Ishihara R
AD  - Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
FAU - Takata, Norio
AU  - Takata N
AD  - Central Institute for Experimental Animals, Kawasaki, Japan.
AD  - Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
FAU - Matsumoto, Morio
AU  - Matsumoto M
AD  - Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, 
      Japan.
FAU - Mimura, Masaru
AU  - Mimura M
AD  - Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
FAU - Okano, Hideyuki
AU  - Okano H
AD  - Department of Physiology, Keio University School of Medicine, Tokyo, Japan. 
      hidokano@a2.keio.jp.
AD  - Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, 
      Wako-shi, Saitama, 351-0198, Japan. hidokano@a2.keio.jp.
FAU - Nakamura, Masaya
AU  - Nakamura M
AD  - Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, 
      Japan. masa@keio.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180926
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Animals
MH  - *Connectome
MH  - Female
MH  - *Magnetic Resonance Imaging
MH  - Mice
MH  - *Motor Cortex/diagnostic imaging/physiopathology
MH  - *Neuronal Plasticity
MH  - *Somatosensory Cortex/diagnostic imaging/physiopathology
MH  - *Spinal Cord Injuries/diagnostic imaging/physiopathology
MH  - *Wakefulness
PMC - PMC6158265
COIS- H.O. serves as a paid scientific advisor at SanBio Co. Ltd. and K Pharma Inc., 
      M.N. serves as a paid scientific advisor at K Pharma Inc. The other authors 
      declare no competing financial interests.
EDAT- 2018/09/28 06:00
MHDA- 2019/10/28 06:00
PMCR- 2018/09/26
CRDT- 2018/09/28 06:00
PHST- 2017/07/17 00:00 [received]
PHST- 2018/07/26 00:00 [accepted]
PHST- 2018/09/28 06:00 [entrez]
PHST- 2018/09/28 06:00 [pubmed]
PHST- 2019/10/28 06:00 [medline]
PHST- 2018/09/26 00:00 [pmc-release]
AID - 10.1038/s41598-018-32766-8 [pii]
AID - 32766 [pii]
AID - 10.1038/s41598-018-32766-8 [doi]
PST - epublish
SO  - Sci Rep. 2018 Sep 26;8(1):14406. doi: 10.1038/s41598-018-32766-8.