PMID- 30258300
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 1524-5012 (Print)
IS  - 1524-5012 (Linking)
VI  - 18
IP  - 2
DP  - 2018 Summer
TI  - Multiple Endocrine Neoplasia Type 1: A Case Report With Review of Imaging 
      Findings.
PG  - 170-175
LID - 10.31486/toj.17.0019 [doi]
AB  - BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1) is a rare, autosomal 
      dominant inherited syndrome caused by mutations in the MEN1 tumor suppressor 
      gene. The diagnosis is defined clinically by the presence of 2 or more primary 
      MEN1 tumors (parathyroid, anterior pituitary, and pancreatic islet). We describe 
      the case of a patient who presented with classic history and imaging findings for 
      MEN1. CASE REPORT: A male in his early thirties with a history of 
      hyperparathyroidism and a transsphenoidal prolactinoma resection presented years 
      later with abdominal symptoms concerning for Zollinger-Ellison syndrome: 
      worsening epigastric abdominal pain, nausea, vomiting, and diarrhea. 
      Contrast-enhanced computed tomography (CT) of the abdomen revealed hyperenhancing 
      pancreatic lesions and duodenal inflammation, suggesting pancreatic 
      neuroendocrine tumor (gastrinoma) with secondary duodenitis. Bilateral 
      indeterminate hypoattenuating adrenal nodules were also seen on contrast-enhanced 
      CT, and follow-up magnetic resonance imaging confirmed benign adrenal adenomas. 
      Furthermore, thyroid ultrasound and sestamibi scintigraphy revealed a parathyroid 
      adenoma. With confirmatory imaging findings, history, and presenting symptoms, 
      the patient was clinically diagnosed with MEN1 syndrome and underwent surgical 
      and medical management. CONCLUSION: This case exhibits the classic history with 
      corresponding imaging findings of MEN1 syndrome, including pancreatic 
      neuroendocrine tumors, parathyroid adenoma, and adrenal adenomas. High clinical 
      suspicion for MEN1 should lead to endocrinology evaluation with appropriate 
      laboratory workup and targeted imaging evaluation of the typical endocrine organs 
      as described for this patient.
FAU - Keller, Hilary R
AU  - Keller HR
AD  - Department of Surgery, Guthrie Robert Packer Hospital, Sayre, PA.
FAU - Record, Jessica L
AU  - Record JL
AD  - Department of Radiology, Ochsner Clinic Foundation, New Orleans, LA.
FAU - Lall, Neil U
AU  - Lall NU
AD  - Department of Radiology, Ochsner Clinic Foundation, New Orleans, LA.
LA  - eng
PT  - Case Reports
PL  - United States
TA  - Ochsner J
JT  - Ochsner journal
JID - 101125795
PMC - PMC6135292
OTO - NOTNLM
OT  - Adrenal gland neoplasms
OT  - Zollinger-Ellison syndrome
OT  - gastrinoma
OT  - multiple endocrine neoplasia type 1
OT  - neuroendocrine tumors
OT  - parathyroid neoplasms
OT  - pituitary neoplasms
EDAT- 2018/09/28 06:00
MHDA- 2018/09/28 06:01
PMCR- 2018/06/01
CRDT- 2018/09/28 06:00
PHST- 2018/09/28 06:00 [entrez]
PHST- 2018/09/28 06:00 [pubmed]
PHST- 2018/09/28 06:01 [medline]
PHST- 2018/06/01 00:00 [pmc-release]
AID - toj.17.0019 [pii]
AID - 10.31486/toj.17.0019 [doi]
PST - ppublish
SO  - Ochsner J. 2018 Summer;18(2):170-175. doi: 10.31486/toj.17.0019.