PMID- 30258310
OWN - NLM
STAT- MEDLINE
DCOM- 20181119
LR  - 20190610
IS  - 1551-4056 (Electronic)
IS  - 0044-0086 (Print)
IS  - 0044-0086 (Linking)
VI  - 91
IP  - 3
DP  - 2018 Sep
TI  - Gallbladder Agenesis: A Case Report.
PG  - 237-241
AB  - Gallbladder agenesis (GA) is an extremely rare congenital entity. The incidence 
      is around 1 per 6500 live births. The majority of patients, estimated between 50 
      to 70 percent, remain asymptomatic while those who are symptomatic report 
      symptoms mimicking biliary colic. Initial workup for suspected gallbladder 
      pathology such as right upper quadrant ultrasound (US) can be misleading or 
      inconclusive. Furthermore, advanced diagnostic studies such as hepatobiliary 
      iminodiacetic acid (HIDA) scan and endoscopic retrograde 
      cholangio-pancreatography (ERCP) may report non-visualization of the gallbladder 
      and erroneously lead providers to a diagnosis of cystic duct obstruction rather 
      than GA. Consequently, some GA patients are only finally diagnosed 
      intraoperatively. Surgery can be risky in these patients because unnecessary 
      dissection while looking for the non-existent gallbladder can result in injury of 
      the biliary tree, hepatic vasculature, or small bowel. Therefore, clinicians 
      should keep GA on their differential diagnosis list and imaging modalities such 
      as magnetic resonance cholangiopancreatography (MRCP) should be obtained when 
      other tests prove inconclusive. We report a 35-year-old female presenting with 
      chronic symptoms consistent with biliary colic and an equivocal US reported as 
      cholelithiasis. She underwent laparoscopy during which the absence of the 
      gallbladder was noted. Postoperative MRCP confirmed the diagnosis of GA.
FAU - Salazar, Michelle C
AU  - Salazar MC
AD  - Department of Surgery, Yale School of Medicine, New Haven, CT.
FAU - Brownson, Kirstyn E
AU  - Brownson KE
AD  - Department of Surgery, Yale School of Medicine, New Haven, CT.
FAU - Nadzam, Geoffrey S
AU  - Nadzam GS
AD  - Section of Gastrointestinal Surgery, Department of Surgery, Yale School of 
      Medicine, New Haven, CT.
FAU - Duffy, Andrew
AU  - Duffy A
AD  - Section of Gastrointestinal Surgery, Department of Surgery, Yale School of 
      Medicine, New Haven, CT.
FAU - Roberts, Kurt E
AU  - Roberts KE
AD  - Section of Gastrointestinal Surgery, Department of Surgery, Yale School of 
      Medicine, New Haven, CT.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20180921
PL  - United States
TA  - Yale J Biol Med
JT  - The Yale journal of biology and medicine
JID - 0417414
RN  - Gallbladder, Agenesis Of
SB  - IM
MH  - Adult
MH  - Cholecystitis/diagnosis
MH  - Choledocholithiasis/diagnosis
MH  - Congenital Abnormalities/*diagnosis
MH  - Diagnosis, Differential
MH  - Female
MH  - Gallbladder/*abnormalities/pathology
MH  - Humans
PMC - PMC6153629
OTO - NOTNLM
OT  - Biliary Colic
OT  - Cholecystitis
OT  - Choledocholithiasis
OT  - Gallbladder agenesis
EDAT- 2018/09/28 06:00
MHDA- 2018/11/20 06:00
PMCR- 2018/09/21
CRDT- 2018/09/28 06:00
PHST- 2018/09/28 06:00 [entrez]
PHST- 2018/09/28 06:00 [pubmed]
PHST- 2018/11/20 06:00 [medline]
PHST- 2018/09/21 00:00 [pmc-release]
AID - yjbm913237 [pii]
PST - epublish
SO  - Yale J Biol Med. 2018 Sep 21;91(3):237-241. eCollection 2018 Sep.