PMID- 30258373
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 9
DP  - 2018
TI  - Role of Frontostriatal Connectivity in Adolescents With Excessive Smartphone Use.
PG  - 437
LID - 10.3389/fpsyt.2018.00437 [doi]
LID - 437
AB  - As smartphone use has grown rapidly over recent decade, it has been a growing 
      interest in the potential negative impact of excessive smartphone use. In this 
      study, we aim to identify altered brain connectivity associated with excessive 
      smartphone use, and to investigate correlations between withdrawal symptoms, 
      cortisol concentrations, and frontostriatal connectivity. We focused on 
      investigating functional connectivity in frontostriatal regions, including the 
      orbitofrontal cortex (OFC), midcingulate cortex (MCC), and nucleus accumbens 
      (NAcc), which is related to reward processing and cognitive control. We analyzed 
      data from 38 adolescents with excessive smartphone use (SP) and 42 healthy 
      controls (HC). In the SP group compared with HC, we observed lower functional 
      connectivity between the right OFC and NAcc, and between the left OFC and MCC. 
      Moreover, functional connectivity between the MCC and NAcc was greater in SP 
      compared with HC. Subsequently, we examined the relationship between Internet use 
      withdrawal symptoms, cortisol concentrations, and functional connectivity between 
      the OFC and NAcc in SP and HC. We observed that more severe withdrawal symptoms 
      were associated with higher cortisol concentrations in adolescents with excessive 
      smartphone use. The most interesting finding was that we observed a negative 
      correlation between OFC connectivity with the NAcc and both withdrawal symptoms 
      and cortisol concentrations. The functional connectivity between the OFC and 
      NAcc, and between the OFC and MCC are related to cognitive control of emotional 
      stimuli including reward. The current study suggests that adolescents with SP had 
      reduced functional connectivity in these regions related to cognitive control. 
      Furthermore, Internet use withdrawal symptoms appear to elicit cortisol 
      secretion, and this psychophysiological change may affect frontostriatal 
      connectivity. Our findings provide important clues to understanding the effects 
      of excessive use of smartphones on brain functional connectivity in adolescence.
FAU - Chun, Ji-Won
AU  - Chun JW
AD  - Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of 
      Korea College of Medicine, Seoul, South Korea.
FAU - Choi, Jihye
AU  - Choi J
AD  - Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of 
      Korea College of Medicine, Seoul, South Korea.
FAU - Cho, Hyun
AU  - Cho H
AD  - Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of 
      Korea College of Medicine, Seoul, South Korea.
AD  - Department of Psychology, Korea University, Seoul, South Korea.
FAU - Choi, Mi-Ran
AU  - Choi MR
AD  - Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of 
      Korea College of Medicine, Seoul, South Korea.
FAU - Ahn, Kook-Jin
AU  - Ahn KJ
AD  - Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of 
      Korea College of Medicine, Seoul, South Korea.
FAU - Choi, Jung-Seok
AU  - Choi JS
AD  - Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul, South Korea.
FAU - Kim, Dai-Jin
AU  - Kim DJ
AD  - Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of 
      Korea College of Medicine, Seoul, South Korea.
LA  - eng
PT  - Journal Article
DEP - 20180912
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC6143708
OTO - NOTNLM
OT  - cortisol
OT  - excessive smartphone use
OT  - frontostriatal connectivity
OT  - problematic internet use
OT  - withdrawal
EDAT- 2018/09/28 06:00
MHDA- 2018/09/28 06:01
PMCR- 2018/09/12
CRDT- 2018/09/28 06:00
PHST- 2018/03/29 00:00 [received]
PHST- 2018/08/23 00:00 [accepted]
PHST- 2018/09/28 06:00 [entrez]
PHST- 2018/09/28 06:00 [pubmed]
PHST- 2018/09/28 06:01 [medline]
PHST- 2018/09/12 00:00 [pmc-release]
AID - 10.3389/fpsyt.2018.00437 [doi]
PST - epublish
SO  - Front Psychiatry. 2018 Sep 12;9:437. doi: 10.3389/fpsyt.2018.00437. eCollection 
      2018.