PMID- 30259307
OWN - NLM
STAT- MEDLINE
DCOM- 20190416
LR  - 20210109
IS  - 1439-0973 (Electronic)
IS  - 0300-8126 (Linking)
VI  - 47
IP  - 1
DP  - 2019 Feb
TI  - Tuberculosis-associated hemophagocytic lymphohistiocytosis with subsequent 
      unmasking cryptococcal immune reconstitution inflammatory syndrome (IRIS) in an 
      HIV-negative man.
PG  - 129-133
LID - 10.1007/s15010-018-1226-1 [doi]
AB  - A 22-year-old HIV-negative man from Ghana was diagnosed with severe 
      hemophagocytic lymphohistiocytosis (HLH) induced by multiorgan tuberculosis with 
      peritoneal, hepatic, pericardial, myocardial, pleural, pulmonary, and bone 
      manifestation. His body mass index was 12.9 m(2)/kg. Bioptic material of a 
      peritoneal biopsy grew M. tuberculosis, sensitive to all first-line 
      antituberculous drugs. HLH resolved with antituberculous therapy, without 
      additional anti-inflammatory therapy being given. The initial CT scan of his 
      brain was normal. After 5 months of antituberculous treatment, he developed a 
      paralysis of the left arm. A cerebral MRT showed ring-enhanced lesions. Blood 
      cultures and lumbar puncture revealed Cryptococcus neoformans var. grubi. The HIV 
      test was repeatedly negative. Antituberculous treatment was continued for a total 
      of 9 months, and additional treatment with antifungal therapy was established. He 
      recovered fully after 14 months of antifungal treatment.
FAU - Geerdes-Fenge, Hilte F
AU  - Geerdes-Fenge HF
AD  - Department of Tropical Medicine and Infectious Diseases, Rostock University 
      Medical Center, Ernst-Heydemann-Str. 6, 18057, Rostock, Germany. 
      hilte.geerdes-fenge@uni-rostock.de.
FAU - Lobermann, Micha
AU  - Lobermann M
AD  - Department of Tropical Medicine and Infectious Diseases, Rostock University 
      Medical Center, Ernst-Heydemann-Str. 6, 18057, Rostock, Germany.
FAU - Hemmer, Christoph J
AU  - Hemmer CJ
AD  - Department of Tropical Medicine and Infectious Diseases, Rostock University 
      Medical Center, Ernst-Heydemann-Str. 6, 18057, Rostock, Germany.
FAU - Benedek, Orsolya
AU  - Benedek O
AD  - Institute for Microbiology, Rostock University Medical Center, 
      Ernst-Heydemann-Str. 6, 18057, Rostock, Germany.
FAU - Reisinger, Emil C
AU  - Reisinger EC
AD  - Department of Tropical Medicine and Infectious Diseases, Rostock University 
      Medical Center, Ernst-Heydemann-Str. 6, 18057, Rostock, Germany.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20180926
PL  - Germany
TA  - Infection
JT  - Infection
JID - 0365307
RN  - 0 (Antifungal Agents)
RN  - 0 (Antitubercular Agents)
SB  - IM
MH  - Antifungal Agents/administration & dosage
MH  - Antitubercular Agents/administration & dosage
MH  - Brain/diagnostic imaging/microbiology/pathology
MH  - Cryptococcosis/*diagnosis/diagnostic imaging/drug therapy/microbiology
MH  - Cryptococcus neoformans/*isolation & purification
MH  - Germany
MH  - Ghana/ethnology
MH  - HIV Seronegativity
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*diagnosis/diagnostic 
      imaging/microbiology
MH  - Lymphohistiocytosis, Hemophagocytic/*diagnosis/drug therapy/microbiology
MH  - Male
MH  - Mycobacterium tuberculosis/isolation & purification
MH  - Tuberculosis/*complications/drug therapy
MH  - Young Adult
OTO - NOTNLM
OT  - Cryptococcosis
OT  - HLH
OT  - Hemophagocytic lymphohistiocytosis
OT  - Tuberculosis
OT  - Unmasking IRIS
EDAT- 2018/09/28 06:00
MHDA- 2019/04/17 06:00
CRDT- 2018/09/28 06:00
PHST- 2018/07/03 00:00 [received]
PHST- 2018/09/24 00:00 [accepted]
PHST- 2018/09/28 06:00 [pubmed]
PHST- 2019/04/17 06:00 [medline]
PHST- 2018/09/28 06:00 [entrez]
AID - 10.1007/s15010-018-1226-1 [pii]
AID - 10.1007/s15010-018-1226-1 [doi]
PST - ppublish
SO  - Infection. 2019 Feb;47(1):129-133. doi: 10.1007/s15010-018-1226-1. Epub 2018 Sep 
      26.