PMID- 30259774
OWN - NLM
STAT- MEDLINE
DCOM- 20190114
LR  - 20190114
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 46
IP  - 11
DP  - 2018 Nov
TI  - Optical coherence tomography findings predictive of response to treatment in 
      diabetic macular edema.
PG  - 4455-4464
LID - 10.1177/0300060518798503 [doi]
AB  - OBJECTIVE: To evaluate the short-term efficacy of intravitreal bevacizumab (IVB) 
      and posterior sub-tenon triamcinolone injections (PSTI) on the basis of 
      spectral-domain optical coherence tomography (SD-OCT) patterns in diabetic 
      macular edema (DME). METHODS: We retrospectively reviewed 73 eyes of 73 patients 
      with DME. Based on the presence of serous retinal detachment (SRD), eyes were 
      categorized into two groups, and either IVB or PSTI treatment was performed. 
      Central macular thickness (CMT) and the degree of SRD were assessed 
      preoperatively and 1 month postoperatively. The severity of intraretinal edema 
      was approximated based on the distance from the external limiting membrane to the 
      internal limiting membrane. RESULTS: In eyes with SRD, reduction of SRD was 
      greater with IVB than with PSTI. Moreover, reduction of intraretinal edema was 
      greater with PSTI than with IVB. In eyes without SRD, PSTI achieved greater CMT 
      reduction, compared with IVB. CONCLUSIONS: In DME patients with SRD, IVB achieved 
      greater reduction of SRD, compared with PSTI; however, intraretinal edema 
      responded more favorably to PSTI, regardless of the presence of SRD. Our results 
      suggest that the classification of DME based on OCT findings may be useful to 
      predict responses to IVB or PSTI treatments.
FAU - Cho, Young Joo
AU  - Cho YJ
AD  - 1 Department of Ophthalmology, HanGil Eye Hospital, Incheon, Korea.
FAU - Lee, Dong Hyun
AU  - Lee DH
AD  - 2 Institute of Vision Research, Department of Ophthalmology, Severance Eye and 
      ENT Hospital, Yonsei, University College of Medicine, Seoul, Republic of Korea.
FAU - Kim, Min
AU  - Kim M
AUID- ORCID: 0000-0003-1873-6959
AD  - 3 Department of Ophthalmology, Gangnam Severance Hospital, Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20180927
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
SB  - IM
MH  - Diabetic Retinopathy/*diagnostic imaging/*drug therapy
MH  - Female
MH  - Humans
MH  - Macular Edema/*diagnostic imaging/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Retinal Detachment/complications/pathology
MH  - *Tomography, Optical Coherence
MH  - Treatment Outcome
PMC - PMC6259392
OTO - NOTNLM
OT  - Diabetic macular edema
OT  - diabetic retinopathy
OT  - edema
OT  - intravitreal bevacizumab
OT  - optical coherence tomography
OT  - posterior sub-tenon triamcinolone
OT  - retina
OT  - serous retinal detachment
EDAT- 2018/09/28 06:00
MHDA- 2019/01/15 06:00
PMCR- 2018/11/01
CRDT- 2018/09/28 06:00
PHST- 2018/09/28 06:00 [pubmed]
PHST- 2019/01/15 06:00 [medline]
PHST- 2018/09/28 06:00 [entrez]
PHST- 2018/11/01 00:00 [pmc-release]
AID - 10.1177_0300060518798503 [pii]
AID - 10.1177/0300060518798503 [doi]
PST - ppublish
SO  - J Int Med Res. 2018 Nov;46(11):4455-4464. doi: 10.1177/0300060518798503. Epub 
      2018 Sep 27.