PMID- 30260258
OWN - NLM
STAT- MEDLINE
DCOM- 20191030
LR  - 20200309
IS  - 1461-7285 (Electronic)
IS  - 0269-8811 (Print)
IS  - 0269-8811 (Linking)
VI  - 32
IP  - 10
DP  - 2018 Oct
TI  - Anhedonia and depression severity dissociated by dmPFC resting-state functional 
      connectivity in adolescents.
PG  - 1067-1074
LID - 10.1177/0269881118799935 [doi]
AB  - INTRODUCTION: Given the heterogeneity within depression, in this study we aim to 
      examine how resting-state functional connectivity (RSFC) in adolescents is 
      related to anhedonia and depression severity on a continuum in line with the 
      research domain criteria (RDoC) approach. METHODS: We examined how RSFC in the 
      dorsal medial prefrontal cortex (dmPFC), nucleus accumbens (NAcc) and pregenual 
      anterior cingulate cortex (pgACC) was related to anhedonia and depression 
      severity in 86 adolescents (13-21 years). RESULTS: We found both anhedonia and 
      depression severity related to decreased dmPFC RSFC with the precuneus, a part of 
      the default mode network. However we also found that increased dmPFC connectivity 
      with the ACC/paracingulate gyrus related to anhedonia whereas increased RSFC with 
      the frontal pole related to depression severity. DISCUSSION: This work extends 
      the view that the dmPFC is a potential therapeutic target for depression in two 
      ways: 1. We report dmPFC connectivity in adolescents; and 2. We show different 
      dmPFC RSFC specific to anhedonia and depression severity, providing neural 
      targets for intervention in young people at risk of depression.
FAU - Rzepa, Ewelina
AU  - Rzepa E
AD  - School of Psychology and Clinical Language Sciences, University of Reading, UK.
FAU - McCabe, Ciara
AU  - McCabe C
AUID- ORCID: 0000-0001-8704-3473
AD  - School of Psychology and Clinical Language Sciences, University of Reading, UK.
LA  - eng
GR  - MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180927
PL  - United States
TA  - J Psychopharmacol
JT  - Journal of psychopharmacology (Oxford, England)
JID - 8907828
SB  - IM
MH  - Adolescent
MH  - Anhedonia/*physiology
MH  - Brain/*diagnostic imaging
MH  - *Brain Mapping
MH  - Depressive Disorder, Major/diagnostic imaging/*physiopathology
MH  - Female
MH  - Gyrus Cinguli/diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/diagnostic imaging
MH  - Nucleus Accumbens/diagnostic imaging
MH  - Prefrontal Cortex/diagnostic imaging
MH  - Severity of Illness Index
MH  - Young Adult
PMC - PMC6380625
OTO - NOTNLM
OT  - DMN
OT  - Depression
OT  - adolescent
OT  - biomarker
OT  - dmPFC
OT  - resting-state
COIS- Declaration of conflicting interest: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article
EDAT- 2018/09/28 06:00
MHDA- 2019/10/31 06:00
PMCR- 2019/02/19
CRDT- 2018/09/28 06:00
PHST- 2018/09/28 06:00 [pubmed]
PHST- 2019/10/31 06:00 [medline]
PHST- 2018/09/28 06:00 [entrez]
PHST- 2019/02/19 00:00 [pmc-release]
AID - 10.1177_0269881118799935 [pii]
AID - 10.1177/0269881118799935 [doi]
PST - ppublish
SO  - J Psychopharmacol. 2018 Oct;32(10):1067-1074. doi: 10.1177/0269881118799935. Epub 
      2018 Sep 27.