PMID- 30260594
OWN - NLM
STAT- MEDLINE
DCOM- 20200911
LR  - 20220202
IS  - 1755-5949 (Electronic)
IS  - 1755-5930 (Print)
IS  - 1755-5930 (Linking)
VI  - 25
IP  - 4
DP  - 2019 Apr
TI  - Nicotinate-curcumin ameliorates cognitive impairment in diabetic rats by rescuing 
      autophagic flux in CA1 hippocampus.
PG  - 430-441
LID - 10.1111/cns.13059 [doi]
AB  - INTRODUCTION: Our previous study has confirmed that a novel curcumin derivate 
      nicotinate-curcumin (NC) can facilitate autophagic flux in THP-1 cells induced by 
      oxidized low-density lipoprotein. AIMS: Given that autophagy plays critical roles 
      in neurodegenerative diseases, the present study was carried out to investigate 
      whether NC can improve cognitive function of rats with diabetes mellitus (DM) via 
      restoring autophagic flux in CA1 hippocampus. RESULTS: Our results showed that NC 
      treatment improved cognitive deficit and attenuated neuronal loss as well as 
      cellular ultrastructure impairment in the CA1 region of DM rats induced by 
      streptozotocin. Moreover, NC lowered the expressions of the apoptosis-related 
      proteins Bcl-2, Bax, Cyt-c, and cleaved Caspase-3. Notably, NC treatment reversed 
      autophagic flux impairment as evidenced by the deceases in LC3-II and p62 protein 
      levels, and autophagosome accumulation in the hippocampal CA1 region of DM rats. 
      However, these protective effects of NC were abolished by cotreatment with 
      3-methyladenine (an autophagy inhibitor) and chloroquine (an autophagic flux 
      inhibitor), respectively. Furthermore, NC treatment decreased the expressions of 
      phosphorylated mammalian target of rapamycin (mTOR) and p70 ribosomal protein S6 
      kinase (p70S6k) proteins in the CA1 region of DM rats. CONCLUSIONS: These results 
      indicate that NC ameliorates DM-induced cognitive function impairment via 
      restoring autophagic flux might by inhibiting mTOR/p70S6k activation in the CA1 
      region, and NC may be a promising agent for diabetic cognitive dysfunction 
      prevention and treatment.
CI  - (c) 2018 John Wiley & Sons Ltd.
FAU - Gu, Hong-Feng
AU  - Gu HF
AUID- ORCID: 0000-0002-4062-7057
AD  - Department of Physiology & Institute of Neuroscience, University of South China, 
      Hengyang, China.
FAU - Li, Na
AU  - Li N
AD  - Department of Physiology & Institute of Neuroscience, University of South China, 
      Hengyang, China.
FAU - Tang, Ya-Ling
AU  - Tang YL
AD  - Department of Physiology & Institute of Neuroscience, University of South China, 
      Hengyang, China.
FAU - Yan, Can-Qun
AU  - Yan CQ
AD  - Department of Endocrine of the Second Affiliated Hospital, University of South 
      China, Hengyang, China.
FAU - Shi, Zhe
AU  - Shi Z
AD  - Division of Stem Cell Regulation and Application, State Key Laboratory of Chinese 
      Medicine Powder and Medicine Innovation in Hunan, Hunan University of Chinese 
      Medicine, Changsha, China.
FAU - Yi, Si-Ni
AU  - Yi SN
AD  - Department of Endocrine of the Second Affiliated Hospital, University of South 
      China, Hengyang, China.
FAU - Zhou, Hao-Ling
AU  - Zhou HL
AD  - Department of Endocrine of the Second Affiliated Hospital, University of South 
      China, Hengyang, China.
FAU - Liao, Duan-Fang
AU  - Liao DF
AD  - Division of Stem Cell Regulation and Application, State Key Laboratory of Chinese 
      Medicine Powder and Medicine Innovation in Hunan, Hunan University of Chinese 
      Medicine, Changsha, China.
FAU - OuYang, Xin-Ping
AU  - OuYang XP
AD  - Department of Physiology & Institute of Neuroscience, University of South China, 
      Hengyang, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180909
PL  - England
TA  - CNS Neurosci Ther
JT  - CNS neuroscience & therapeutics
JID - 101473265
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (curcumin nicotinate)
RN  - 12001-76-2 (Vitamin B Complex)
RN  - 2679MF687A (Niacin)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage
MH  - Autophagy/*drug effects/physiology
MH  - CA1 Region, Hippocampal/*drug effects/metabolism/ultrastructure
MH  - Cognitive Dysfunction/*drug therapy/metabolism/psychology
MH  - Curcumin/*administration & dosage/*analogs & derivatives/pharmacology
MH  - Diabetes Mellitus, Experimental/*drug therapy/metabolism/psychology
MH  - Drug Therapy, Combination
MH  - Male
MH  - Niacin/*administration & dosage/*analogs & derivatives/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Vitamin B Complex/administration & dosage
PMC - PMC6488886
OTO - NOTNLM
OT  - autophagy
OT  - cognitive function
OT  - diabetes mellitus
OT  - hippocampus
OT  - mammalian target of rapamycin complex
OT  - nicotinate-curcumin
COIS- The authors declare no conflict of interest, and all the authors listed have 
      approved the manuscript that is enclosed.
EDAT- 2018/09/28 06:00
MHDA- 2020/09/12 06:00
PMCR- 2018/09/09
CRDT- 2018/09/28 06:00
PHST- 2018/06/09 00:00 [received]
PHST- 2018/08/09 00:00 [revised]
PHST- 2018/08/15 00:00 [accepted]
PHST- 2018/09/28 06:00 [pubmed]
PHST- 2020/09/12 06:00 [medline]
PHST- 2018/09/28 06:00 [entrez]
PHST- 2018/09/09 00:00 [pmc-release]
AID - CNS13059 [pii]
AID - 10.1111/cns.13059 [doi]
PST - ppublish
SO  - CNS Neurosci Ther. 2019 Apr;25(4):430-441. doi: 10.1111/cns.13059. Epub 2018 Sep 
      9.