PMID- 30261068
OWN - NLM
STAT- MEDLINE
DCOM- 20190304
LR  - 20230928
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 9
DP  - 2018
TI  - Stimulating the nucleus accumbens in obesity: A positron emission tomography 
      study after deep brain stimulation in a rodent model.
PG  - e0204740
LID - 10.1371/journal.pone.0204740 [doi]
LID - e0204740
AB  - PURPOSE: The nucleus accumbens (NAcc) has been suggested as a possible target for 
      deep brain stimulation (DBS) in the treatment of obesity. Our hypothesis was that 
      NAcc-DBS would modulate brain regions related to reward and food intake 
      regulation, consequently reducing the food intake and, finally, the weight gain. 
      Therefore, we examined changes in brain glucose metabolism, weight gain and food 
      intake after NAcc-DBS in a rat model of obesity. PROCEDURES: Electrodes were 
      bilaterally implanted in 2 groups of obese Zucker rats targeting the NAcc. One 
      group received stimulation one hour daily during 15 days, while the other 
      remained as control. Weight and daily consumption of food and water were everyday 
      registered the days of stimulation, and twice per week during the following 
      month. Positron emission tomography (PET) studies with 
      2-deoxy-2-[18F]fluoro-D-glucose (FDG) were performed 1 day after the end of DBS. 
      PET data was assessed by statistical parametric mapping (SPM12) software and 
      region of interest (ROI) analyses. RESULTS: NAcc-DBS lead to increased metabolism 
      in the cingulate-retrosplenial-parietal association cortices, and decreased 
      metabolism in the NAcc, thalamic and pretectal nuclei. Furthermore, ROIs analyses 
      confirmed these results by showing a significant striatal and thalamic 
      hypometabolism, and a cortical hypermetabolic region. However, NAcc-DBS did not 
      induce a decrease in either weight gain or food intake. CONCLUSIONS: NAcc-DBS led 
      to changes in the metabolism of regions associated with cognitive and reward 
      systems, whose impairment has been described in obesity.
FAU - Casquero-Veiga, Marta
AU  - Casquero-Veiga M
AUID- ORCID: 0000-0003-0859-9495
AD  - Instituto de Investigacion Sanitaria Gregorio Maranon (IiSGM), Madrid, Spain.
FAU - Garcia-Garcia, David
AU  - Garcia-Garcia D
AD  - Facultad de Ciencia y Tecnologia, Universidad Isabel I, Burgos, Spain.
FAU - Pascau, Javier
AU  - Pascau J
AD  - Instituto de Investigacion Sanitaria Gregorio Maranon (IiSGM), Madrid, Spain.
AD  - CIBER de Salud Mental (CIBERSAM), Madrid, Spain.
AD  - Departamento de Bioingenieria e Ingenieria Aeroespacial, Universidad Carlos III 
      de Madrid, Leganes, Spain.
FAU - Desco, Manuel
AU  - Desco M
AD  - Instituto de Investigacion Sanitaria Gregorio Maranon (IiSGM), Madrid, Spain.
AD  - CIBER de Salud Mental (CIBERSAM), Madrid, Spain.
AD  - Departamento de Bioingenieria e Ingenieria Aeroespacial, Universidad Carlos III 
      de Madrid, Leganes, Spain.
AD  - Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
FAU - Soto-Montenegro, Maria Luisa
AU  - Soto-Montenegro ML
AD  - Instituto de Investigacion Sanitaria Gregorio Maranon (IiSGM), Madrid, Spain.
AD  - CIBER de Salud Mental (CIBERSAM), Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180927
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Animals
MH  - *Deep Brain Stimulation
MH  - Disease Models, Animal
MH  - Male
MH  - *Nucleus Accumbens/diagnostic imaging/physiopathology
MH  - *Obesity/diagnostic imaging/physiopathology/therapy
MH  - *Positron-Emission Tomography
MH  - Rats
MH  - Rats, Zucker
PMC - PMC6160153
COIS- The authors have declared that no competing interests exist.
EDAT- 2018/09/28 06:00
MHDA- 2019/03/05 06:00
PMCR- 2018/09/27
CRDT- 2018/09/28 06:00
PHST- 2018/03/14 00:00 [received]
PHST- 2018/09/13 00:00 [accepted]
PHST- 2018/09/28 06:00 [entrez]
PHST- 2018/09/28 06:00 [pubmed]
PHST- 2019/03/05 06:00 [medline]
PHST- 2018/09/27 00:00 [pmc-release]
AID - PONE-D-18-07882 [pii]
AID - 10.1371/journal.pone.0204740 [doi]
PST - epublish
SO  - PLoS One. 2018 Sep 27;13(9):e0204740. doi: 10.1371/journal.pone.0204740. 
      eCollection 2018.