PMID- 30262417
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20230918
IS  - 1532-2785 (Electronic)
IS  - 0143-4179 (Linking)
VI  - 72
DP  - 2018 Dec
TI  - Brain-derived neurotrophic factor and epilepsy: a systematic review.
PG  - 23-29
LID - S0143-4179(18)30065-9 [pii]
LID - 10.1016/j.npep.2018.09.005 [doi]
AB  - Several in vitro, ex vivo and in vivo studies imply brain-derived neurotrophic 
      factor (BDNF) in the pathophysiology of epilepsy. Aim of our work is to report 
      the most important findings regarding BDNF and its potential role in epilepsy. We 
      targeted those publications addressing both in vitro and in vivo evidences of 
      relationship between BDNF and epilepsy. Basic researches, randomized trials, 
      cohort studies, and reviews were contemplated to give a breadth of clinical data. 
      Medline, CENTRAL, and Science Direct were searched till August 2017 using 
      keywords agreed by the authors. Together with a defined role in developmental and 
      mature brain, BDNF has excitatory effects in neuronal cultures and animal brain 
      slices. Furthermore, both BDNF and its conjugated receptor (i.e. Tropomyosin 
      receptor kinase B or TrkB) are increased in animal models and humans with 
      epilepsy, particularly in the temporal and hippocampal areas. Acute injection of 
      BDNF in brain of mice induces seizures, which are almost or totally abolished 
      blocking its transcription and pathway. Chronic infusion of BDNF is conversely 
      associated with a decreased neuronal excitability, probably via several mechanism 
      including an increase in central levels of neuropeptide Y (NPY), altered 
      conductance of chloride, and downregulation of TrkB. While genetic studies are 
      inconclusive, serum BDNF is more frequently higher in patients with epilepsy and 
      appears to be correlated to severity of disease. Current evidences suggest that 
      inhibiting BDNF-TrkB signaling and reinforcing the NPY system could represent a 
      potential therapeutic strategy for epilepsy, especially for temporal lobe 
      epilepsy.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Iughetti, Lorenzo
AU  - Iughetti L
AD  - Department of Medical and Surgical Sciences of the Mother, Children and Adults. 
      University of Modena and Reggio Emilia, Via del Pozzo n. 71, 41124 Modena, Italy. 
      Electronic address: iughetti.lorenzo@unimore.it.
FAU - Lucaccioni, Laura
AU  - Lucaccioni L
AD  - Department of Medical and Surgical Sciences of the Mother, Children and Adults. 
      University of Modena and Reggio Emilia, Via del Pozzo n. 71, 41124 Modena, Italy.
FAU - Fugetto, Francesco
AU  - Fugetto F
AD  - Department of Medical and Surgical Sciences of the Mother, Children and Adults. 
      University of Modena and Reggio Emilia, Via del Pozzo n. 71, 41124 Modena, Italy.
FAU - Predieri, Barbara
AU  - Predieri B
AD  - Department of Medical and Surgical Sciences of the Mother, Children and Adults. 
      University of Modena and Reggio Emilia, Via del Pozzo n. 71, 41124 Modena, Italy.
FAU - Berardi, Alberto
AU  - Berardi A
AD  - Department of Medical and Surgical Sciences of the Mother, Children and Adults. 
      University of Modena and Reggio Emilia, Via del Pozzo n. 71, 41124 Modena, Italy.
FAU - Ferrari, Fabrizio
AU  - Ferrari F
AD  - Department of Medical and Surgical Sciences of the Mother, Children and Adults. 
      University of Modena and Reggio Emilia, Via del Pozzo n. 71, 41124 Modena, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20180920
PL  - Netherlands
TA  - Neuropeptides
JT  - Neuropeptides
JID - 8103156
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Epilepsy/*metabolism
MH  - Humans
MH  - Neurons/*metabolism
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Epilepsy
OT  - Epileptogenesis
OT  - Neurotrophins
EDAT- 2018/09/29 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/09/29 06:00
PHST- 2018/04/17 00:00 [received]
PHST- 2018/08/13 00:00 [revised]
PHST- 2018/09/19 00:00 [accepted]
PHST- 2018/09/29 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/09/29 06:00 [entrez]
AID - S0143-4179(18)30065-9 [pii]
AID - 10.1016/j.npep.2018.09.005 [doi]
PST - ppublish
SO  - Neuropeptides. 2018 Dec;72:23-29. doi: 10.1016/j.npep.2018.09.005. Epub 2018 Sep 
      20.