PMID- 3026275
OWN - NLM
STAT- MEDLINE
DCOM- 19870206
LR  - 20161123
IS  - 0003-9683 (Print)
IS  - 0003-9683 (Linking)
VI  - 79
IP  - 6
DP  - 1986 Jun
TI  - [Antihypertensive action and inhibition of tissue conversion enzyme by ramipril, 
      perindopril and enalapril in the spontaneously hypertensive rat (SHRSP)].
PG  - 971-4
AB  - Ramipril and perindopril, the active diacids of two new converting enzyme (CE) 
      inhibitors proved to possess a similar inhibitory potency against rat plasma CE 
      in vitro. These diacid compounds were more active than enalaprilic acid or 
      captopril. In stroke-prone spontaneously hypertensive rats (SHRSP) chronic oral 
      treatment for two weeks with enalapril (30 mg/kg per day), ramipril or 
      perindopril (each 1 mg/kg per day) normalized blood pressure. The CE 
      inhibitor-induced changes in parameters of the plasma renin-angiotensin system 
      (angiotensin I, angiotensin II, PRC, CE activity) followed the expected pattern, 
      but were not quantitatively related to the antihypertensive action of the three 
      inhibitors. Four weeks of oral equi-dose treatment with the three CE inhibitors 
      (10 mg/kg per day) inhibited tissue CE activity in various organs including 
      kidney, heart, vascular wall and brain. Ramipril and perindopril lowered blood 
      pressure and tissue CE activity more potently than enalapril. These results 
      confirm the hypothesis that CE inhibition in tissue with subsequent local 
      reduction of ANG II synthesis may contribute to the antihypertensive mechanisms 
      of CE inhibitors.
FAU - Unger, T
AU  - Unger T
FAU - Moursi, M G
AU  - Moursi MG
FAU - Lebrun, C
AU  - Lebrun C
FAU - Ganten, D
AU  - Ganten D
FAU - Lang, R E
AU  - Lang RE
LA  - fre
PT  - Comparative Study
PT  - Journal Article
TT  - Action antihypertensive et inhibition de l'enzyme de conversion tissulaire par 
      ramipril, perindopril et enalapril chez des rats spontanement hypertendus 
      (SHRSP).
PL  - France
TA  - Arch Mal Coeur Vaiss
JT  - Archives des maladies du coeur et des vaisseaux
JID - 0406011
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Bridged Bicyclo Compounds)
RN  - 0 (Bridged-Ring Compounds)
RN  - 0 (Indoles)
RN  - 69PN84IO1A (Enalapril)
RN  - L35JN3I7SJ (Ramipril)
RN  - Y5GMK36KGY (Perindopril)
SB  - IM
MH  - *Angiotensin-Converting Enzyme Inhibitors
MH  - Animals
MH  - Antihypertensive Agents/*therapeutic use
MH  - Bridged Bicyclo Compounds/pharmacology/*therapeutic use
MH  - Bridged-Ring Compounds/*therapeutic use
MH  - Enalapril/pharmacology/*therapeutic use
MH  - Humans
MH  - Hypertension/*drug therapy
MH  - Indoles/pharmacology/*therapeutic use
MH  - Male
MH  - Perindopril
MH  - Ramipril
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred Strains
EDAT- 1986/06/01 00:00
MHDA- 1986/06/01 00:01
CRDT- 1986/06/01 00:00
PHST- 1986/06/01 00:00 [pubmed]
PHST- 1986/06/01 00:01 [medline]
PHST- 1986/06/01 00:00 [entrez]
PST - ppublish
SO  - Arch Mal Coeur Vaiss. 1986 Jun;79(6):971-4.