PMID- 30263003
OWN - NLM
STAT- MEDLINE
DCOM- 20190909
LR  - 20230928
IS  - 1449-2288 (Electronic)
IS  - 1449-2288 (Linking)
VI  - 14
IP  - 11
DP  - 2018
TI  - Depressive symptoms in patients with irritable bowel syndrome: a meta-analysis of 
      comparative studies.
PG  - 1504-1512
LID - 10.7150/ijbs.25001 [doi]
AB  - Depression is common in patients with irritable bowel syndrome (IBS), but the 
      reported prevalence across different studies is inconsistent. This meta-analysis 
      systematically examined the presence and severity of depressive symptoms in 
      patients with IBS. Two investigators independently performed a literature search. 
      The pooled depressive symptom severity was calculated using a random effects 
      model. Subgroup, sensitivity and meta-regression analyses were conducted to 
      examine the moderating factors of the development of depressive symptoms. Twenty 
      four studies (n=2,837) comparing depressive symptoms between IBS patients 
      (n=1,775) and healthy controls (n=1,062) were identified; 14 (58.3%) studies were 
      rated as high quality. Compared to healthy controls, IBS patients had more 
      frequent (OR=9.21, 95%CI: 4.56-18.57, P<0.001; I(2)=76%) and more severe 
      depressive symptoms (n=1,480, SMD=2.02, 95%CI: 1.56-2.48, P<0.001; I(2)=94%). 
      Subgroup analyses revealed that patients with all IBS subtypes had more severe 
      depressive symptoms than controls. In addition, versions of the Hamilton 
      Depression Rating Scale (HAM-D) and IBS diagnostic criteria were significantly 
      associated with depressive symptom severity. Meta-regression analyses revealed 
      that female gender, younger age and small sample size were significantly 
      associated with more severe depressive symptoms. In conclusion, meta-analytic 
      data showed that IBS patients had more frequent and severe depressive symptoms 
      than healthy controls. Adequate screening and treatment for depression should be 
      developed and implemented in this patient population.
FAU - Zhang, Qing-E
AU  - Zhang QE
AD  - The National Clinical Research Center for Mental Disorders & Beijing Key 
      Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical 
      University, Beijing, China.
FAU - Wang, Fei
AU  - Wang F
AD  - Guangdong Mental Health Center, Guangdong General Hospital & Guangdong Academy of 
      Medical Sciences, Guangdong Province, China.
AD  - Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, 
      China.
FAU - Qin, Geng
AU  - Qin G
AD  - Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, China.
FAU - Zheng, Wei
AU  - Zheng W
AD  - The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai 
      Hospital), Guangzhou, China.
FAU - Ng, Chee H
AU  - Ng CH
AD  - Department of Psychiatry, University of Melbourne, Melbourne, Victoria, 
      Australia.
FAU - Ungvari, Gabor S
AU  - Ungvari GS
AD  - University of Notre Dame Australia, Perth, Australia.
AD  - Division of Psychiatry, University of Western Australia Medical School, Perth, 
      Australia.
FAU - Yuan, Zhen
AU  - Yuan Z
AD  - Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, 
      China.
FAU - Mei, Songli
AU  - Mei S
AD  - School of Public Health, Jilin University, Jilin province, China.
FAU - Wang, Gang
AU  - Wang G
AD  - The National Clinical Research Center for Mental Disorders & Beijing Key 
      Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical 
      University, Beijing, China.
FAU - Xiang, Yu-Tao
AU  - Xiang YT
AD  - Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, 
      China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20180815
PL  - Australia
TA  - Int J Biol Sci
JT  - International journal of biological sciences
JID - 101235568
SB  - IM
MH  - Cross-Sectional Studies
MH  - Depression/*physiopathology/*psychology
MH  - Female
MH  - Humans
MH  - Irritable Bowel Syndrome/*physiopathology/*psychology
MH  - Male
MH  - Quality of Life
PMC - PMC6158731
OTO - NOTNLM
OT  - IBS
OT  - controlled studies
OT  - depressive symptoms
OT  - meta-analysis
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2018/09/29 06:00
MHDA- 2019/09/10 06:00
PMCR- 2018/01/01
CRDT- 2018/09/29 06:00
PHST- 2018/01/17 00:00 [received]
PHST- 2018/05/13 00:00 [accepted]
PHST- 2018/09/29 06:00 [entrez]
PHST- 2018/09/29 06:00 [pubmed]
PHST- 2019/09/10 06:00 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - ijbsv14p1504 [pii]
AID - 10.7150/ijbs.25001 [doi]
PST - epublish
SO  - Int J Biol Sci. 2018 Aug 15;14(11):1504-1512. doi: 10.7150/ijbs.25001. 
      eCollection 2018.