PMID- 30263017
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240426
IS  - 1507-1367 (Print)
IS  - 2083-4640 (Electronic)
IS  - 1507-1367 (Linking)
VI  - 23
IP  - 5
DP  - 2018 Sep-Oct
TI  - Nanoparticles and nanothermia for malignant brain tumors, a suggestion of 
      treatment for further investigations.
PG  - 474-480
LID - 10.1016/j.rpor.2018.08.001 [doi]
AB  - The current treatment for brain tumors, such as glioblastoma multiforme (GBM), 
      has not been developed enough yet in order to fully heal them. The main causes 
      are the lack of specificity of the treatments, the difficulty of passage of drugs 
      through the blood-brain barrier, heterogeneity and tumor aggressiveness, and 
      widespread dissemination in the brain. The application of nanoparticles (Nps) 
      have been a breakthrough for both diagnostic imaging and targeted therapies. 
      There have been numerous studies with different types of Nps in brain tumors, but 
      we have focused on thermosensitive liposomes, which are characterized by 
      releasing the chemotherapeutic agent included within its lipophilic membranes 
      through heat. Furthermore, increasing the temperature in brain tumors through 
      hyperthermia has been proven therapeutically beneficial. Nanothermia or 
      modulated-electro-hyperthermia (MEHT) is an improved technique that allows to 
      create hot spots in nanorange at the membrane rafts, specifically in tumor cells, 
      theoretically increasing the selectivity of the damage. In scientific records, 
      experiments that combine both techniques (thermosensitive liposomes and 
      nanothermia) have never been conducted. We propose a hypothesis for further 
      research.
FAU - Prieto, Cristina
AU  - Prieto C
AD  - Radiation Oncology Department, University Hospital San Cecilio, Av. Dr. Oloriz 
      16, 18012 Granada, Spain.
FAU - Linares, Isabel
AU  - Linares I
AD  - Radiation Oncology Department, Institut Catala d'Oncologia, Avinguda Granvia, 
      199-203, 08908, L'Hospitalet de Llobregat, Barcelona, Spain.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180906
PL  - Poland
TA  - Rep Pract Oncol Radiother
JT  - Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer 
      Center in Poznan and Polish Society of Radiation Oncology
JID - 100885761
PMC - PMC6158037
OTO - NOTNLM
OT  - GBM
OT  - Liposomes
OT  - MEHT
OT  - Nanoparticles
OT  - Termosensitive
EDAT- 2018/09/29 06:00
MHDA- 2018/09/29 06:01
PMCR- 2019/09/01
CRDT- 2018/09/29 06:00
PHST- 2018/02/28 00:00 [received]
PHST- 2018/06/19 00:00 [revised]
PHST- 2018/08/09 00:00 [accepted]
PHST- 2018/09/29 06:00 [entrez]
PHST- 2018/09/29 06:00 [pubmed]
PHST- 2018/09/29 06:01 [medline]
PHST- 2019/09/01 00:00 [pmc-release]
AID - S1507-1367(18)30102-0 [pii]
AID - 10.1016/j.rpor.2018.08.001 [doi]
PST - ppublish
SO  - Rep Pract Oncol Radiother. 2018 Sep-Oct;23(5):474-480. doi: 
      10.1016/j.rpor.2018.08.001. Epub 2018 Sep 6.