PMID- 30263566
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2092-6456 (Electronic)
IS  - 1226-7708 (Print)
IS  - 1226-7708 (Linking)
VI  - 26
IP  - 2
DP  - 2017
TI  - Anti-allergic and anti-inflammatory activity of Phellinus linteus grown on Panax 
      ginseng.
PG  - 467-472
LID - 10.1007/s10068-017-0064-8 [doi]
AB  - Panax ginseng (PG) or Phellinus linteus (PL) have been widely used as traditional 
      medicine owing to their many biological activities, including anti-inflammatory 
      and anti-allergic activities. Previously, our group produced PL that was grown on 
      PG media (PGP) to enhance anti-cancer activities of PGP. Here we studied the 
      anti-allergic activity of PGP and its mechanism of action. The ethyl acetate 
      fraction of PGP exhibited the anti-allergic activity by suppressing 
      beta-hexosaminidase release, a marker of degranulation, from antigen/immunoglobulin 
      E (IgE)-stimulated RBL-2H3 cells. Exposure to PGP inhibited the level of 
      antigen/IgE-induced TNF-alpha in RBL-2H3 cells. It markedly suppressed the 
      phosphorylation of spleen associated tyrosine kinase, GRB2-associated-binding 
      protein 2 (Gab2) and extracellular signal-regulated kinases proteins, which are 
      required for the degranulation and production of pro-inflammatory cytokines. Its 
      anti-inflammatory activity was observed in lipopolysaccharide-stimulated RAW 
      264.7 cells. In addition, PGP contained higher contents of Rg1 than PG. Our 
      findings suggest that PGP might be developed as a therapeutic agent for 
      IgE-mediated allergic diseases.
FAU - Park, Hye-Jin
AU  - Park HJ
AD  - Department of Food Science and Biotechnology, College of BioNano Technology, 
      Gachon University, Seongnam, Gyeonggi, 13120 Korea. ISNI: 0000 0004 0647 2973. 
      GRID: grid.256155.0
LA  - eng
PT  - Journal Article
DEP - 20170430
PL  - Korea (South)
TA  - Food Sci Biotechnol
JT  - Food science and biotechnology
JID - 9816587
PMC - PMC6049448
OTO - NOTNLM
OT  - PGP
OT  - anti-allergic activity
OT  - anti-inflammatory activity
EDAT- 2017/04/30 00:00
MHDA- 2017/04/30 00:01
PMCR- 2018/04/30
CRDT- 2018/09/29 06:00
PHST- 2016/07/14 00:00 [received]
PHST- 2016/12/21 00:00 [revised]
PHST- 2017/01/06 00:00 [accepted]
PHST- 2018/09/29 06:00 [entrez]
PHST- 2017/04/30 00:00 [pubmed]
PHST- 2017/04/30 00:01 [medline]
PHST- 2018/04/30 00:00 [pmc-release]
AID - 64 [pii]
AID - 10.1007/s10068-017-0064-8 [doi]
PST - epublish
SO  - Food Sci Biotechnol. 2017 Apr 30;26(2):467-472. doi: 10.1007/s10068-017-0064-8. 
      eCollection 2017.