PMID- 30263608
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2092-6456 (Electronic)
IS  - 1226-7708 (Print)
IS  - 1226-7708 (Linking)
VI  - 26
IP  - 3
DP  - 2017
TI  - Green lipped mussel oil complex suppresses lipopolysaccharide stimulated 
      inflammation via regulating nuclear factor-kappaB and mitogen activated protein 
      kinases signaling in RAW264.7 murine macrophages.
PG  - 815-822
LID - 10.1007/s10068-017-0091-5 [doi]
AB  - Here we investigated the effect of green lipped mussel oil complex (GLMOC) on 
      inflammation and underlying mechanism in lipopolysaccharide stimulated RAW264.7 
      murine macrophage cells. GLMOC containing green lipped mussel oil (GLMO), olive 
      oil, and vitamin E (10:20:1) can induce significant suppression of iNOS, leading 
      to reduced nitric oxide synthesis, and cyclooxygenase-2, leading to reduced 
      prostaglandin E2 synthesis. In addition, it down-regulated the release of 
      pro-inflammatory cytokines, including tumor necrosis factor-alpha, interleukin 
      (IL)-6, and IL-1beta. Similar to upstream signaling mediators, GLMCO inhibited the 
      degradation of inhibitory kappaB, nuclear translocation of NF-kappaB, and phosphorylation 
      of mitogen activated protein kinases (MAPKs) in a dose-dependent manner. Among 
      the components of GLMOC, GLMO was responsible for anti-inflammatory efficacy. 
      Taken together, GLMOC induces anti-inflammatory activity via regulating NF-kappaB and 
      MAPK signaling in lipopolysaccharide-induced RAW264.7 cells, providing underlying 
      mechanisms that elucidate the anti-inflammatory efficacy of GLMOC.
FAU - Chen, Jing
AU  - Chen J
AD  - 1Department of Food Science and Technology, Chung-Ang University, Anseong, 
      Gyeonggi 17546 Korea. ISNI: 0000 0001 0789 9563. GRID: grid.254224.7
FAU - Bao, Cheng
AU  - Bao C
AD  - 1Department of Food Science and Technology, Chung-Ang University, Anseong, 
      Gyeonggi 17546 Korea. ISNI: 0000 0001 0789 9563. GRID: grid.254224.7
FAU - Cho, Se Haeng
AU  - Cho SH
AD  - Syspang, Seoul, 08378 Korea.
FAU - Lee, Hong Jin
AU  - Lee HJ
AD  - 1Department of Food Science and Technology, Chung-Ang University, Anseong, 
      Gyeonggi 17546 Korea. ISNI: 0000 0001 0789 9563. GRID: grid.254224.7
LA  - eng
PT  - Journal Article
DEP - 20170608
PL  - Korea (South)
TA  - Food Sci Biotechnol
JT  - Food science and biotechnology
JID - 9816587
PMC - PMC6049590
OTO - NOTNLM
OT  - Green lipped mussel oil
OT  - Inflammation
OT  - Mitogen activated protein kinase
OT  - Nuclear factor kappaB
OT  - RAW264.7
COIS- Compliance with ethical standardsThe authors declare no conflict of interest.
EDAT- 2017/06/08 00:00
MHDA- 2017/06/08 00:01
PMCR- 2018/06/08
CRDT- 2018/09/29 06:00
PHST- 2017/01/06 00:00 [received]
PHST- 2017/03/06 00:00 [revised]
PHST- 2017/03/06 00:00 [accepted]
PHST- 2018/09/29 06:00 [entrez]
PHST- 2017/06/08 00:00 [pubmed]
PHST- 2017/06/08 00:01 [medline]
PHST- 2018/06/08 00:00 [pmc-release]
AID - 91 [pii]
AID - 10.1007/s10068-017-0091-5 [doi]
PST - epublish
SO  - Food Sci Biotechnol. 2017 Jun 8;26(3):815-822. doi: 10.1007/s10068-017-0091-5. 
      eCollection 2017.