PMID- 30264364
OWN - NLM
STAT- MEDLINE
DCOM- 20190423
LR  - 20200225
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 35
IP  - 3
DP  - 2019 Mar
TI  - Prospective evaluation of left atrial function and late gadolinium enhancement 
      with 3 T MRI in patients with atrial fibrillation before and after catheter 
      ablation.
PG  - 499-504
LID - 10.1007/s10554-018-1455-5 [doi]
AB  - In a prospective, randomized study we performed left atrial (LA) functional 
      imaging and late gadolinium enhancement (LGE) in patients undergoing pulmonary 
      vein isolation with ablation of the anterior mitral line to evaluate LA function 
      and visibility of the anterior mitral line and to explore the relationship of 
      these factors to short- and long-term procedural success. Functional imaging of 
      the LA and LGE-visualization 15 min post i.v. administration of gadobutrol was 
      performed on a 3 T MRI system before and after ablation. Patients were grouped in 
      (a) subjects with sinus rhythm, and (b) subjects without sinus rhythm at the 
      follow-up-MRI. Eight patients were excluded due to poor image quality. 37 
      patients were allotted to group a, 4 patients to group b. Group a showed a 
      significant improvement in ejection fraction (22.3 +/- 7.1% vs. 27.2 +/- 5.5%; 
      p < 0.001), end-systolic volume (111.6 +/- 48.3 ml vs. 96.9 +/- 37.2 ml; p = 0.002), 
      stroke volume (30.2 +/- 12.6 ml vs. 35.6 +/- 12.6 ml; p = 0.003) and LGE (12.5% vs. 
      83.7%; p < 0.001). Group b showed no significant changes in functional parameters 
      or LGE. Patients with successful therapy at 12 months showed significantly lower 
      volumes in the baseline MRI. Scarring along the ablation pathways could be 
      visualized with LGE. Patients with successful CA showed a significant improvement 
      in LA cardiac parameters. Pre-ablation atrial volume seems to be a predictor for 
      long-term success.
FAU - Curta, Adrian
AU  - Curta A
AUID- ORCID: 0000-0003-1056-2149
AD  - Department of Radiology, University Hospital, LMU Munich, Munich, Germany. 
      adrian.curta@med.uni-muenchen.de.
FAU - Fichtner, Stephanie
AU  - Fichtner S
AD  - Medizinische Klinik und Poliklinik I, University Hospital, LMU Munich, Munich, 
      Germany.
FAU - Wakili, Reza
AU  - Wakili R
AD  - Clinic for Cardiology and Angiology, University Hospital Essen, Essen, Germany.
FAU - Estner, Heidi
AU  - Estner H
AD  - Medizinische Klinik und Poliklinik I, University Hospital, LMU Munich, Munich, 
      Germany.
FAU - Kramer, Harald
AU  - Kramer H
AD  - Department of Radiology, University Hospital, LMU Munich, Munich, Germany.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20180927
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
SB  - IM
MH  - Aged
MH  - Atrial Fibrillation/*diagnostic imaging/physiopathology/*surgery
MH  - *Atrial Function, Left
MH  - *Catheter Ablation/adverse effects
MH  - Contrast Media/*administration & dosage
MH  - Female
MH  - Germany
MH  - Heart Atria/*diagnostic imaging/physiopathology/*surgery
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Organometallic Compounds/*administration & dosage
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Recovery of Function
MH  - Recurrence
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Anterior mitral line
OT  - Atrial fibrillation
OT  - Atrial function
OT  - Cardiac MRI
OT  - Catheter ablation
OT  - Gadolinium late enhancement
OT  - Scarring
EDAT- 2018/09/29 06:00
MHDA- 2019/04/24 06:00
CRDT- 2018/09/29 06:00
PHST- 2018/05/23 00:00 [received]
PHST- 2018/09/17 00:00 [accepted]
PHST- 2018/09/29 06:00 [pubmed]
PHST- 2019/04/24 06:00 [medline]
PHST- 2018/09/29 06:00 [entrez]
AID - 10.1007/s10554-018-1455-5 [pii]
AID - 10.1007/s10554-018-1455-5 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2019 Mar;35(3):499-504. doi: 10.1007/s10554-018-1455-5. 
      Epub 2018 Sep 27.