PMID- 30264378
OWN - NLM
STAT- MEDLINE
DCOM- 20190429
LR  - 20231006
IS  - 1995-8218 (Electronic)
IS  - 1673-7067 (Print)
IS  - 1995-8218 (Linking)
VI  - 35
IP  - 2
DP  - 2019 Apr
TI  - Folate/Vitamin B Alleviates Hyperhomocysteinemia-Induced Alzheimer-Like 
      Pathologies in Rat Retina.
PG  - 325-335
LID - 10.1007/s12264-018-0293-8 [doi]
AB  - Hyperhomocysteinemia (Hhcy) is an independent risk factor for Alzheimer's disease 
      (AD). Visual dysfunction is commonly found and is positively correlated with the 
      severity of cognitive defects in AD patients. Our previous study demonstrated 
      that Hhcy induces memory deficits with AD-like tau and amyloid-beta (Abeta) pathologies 
      in the hippocampus, and supplementation with folate and vitamin B12 (FB) prevents 
      the Hhcy-induced AD-like pathologies in the hippocampus. Here, we investigated 
      whether Hhcy also induces AD-like pathologies in the retina and the effects of 
      FB. An Hhcy rat model was produced by vena caudalis injection of homocysteine for 
      14 days, and the effects of FB were assessed by simultaneous supplementation with 
      FB in drinking water. We found that Hhcy induced vessel damage with Abeta and tau 
      pathologies in the retina, while simultaneous supplementation with FB remarkably 
      attenuated the Hhcy-induced tau hyperphosphorylation at multiple AD-related sites 
      and Abeta accumulation in the retina. The mechanisms involved downregulation of 
      amyloid precursor protein (APP), presenilin-1, beta-site APP-cleaving enzyme 1, 
      and protein phosphatase-2A. Our data suggest that the retina may serve as a 
      window for evaluating the effects of FB on hyperhomocysteinemia-induced 
      Alzheimer-like pathologies.
FAU - Guo, Jing
AU  - Guo J
AD  - Department of Pathophysiology, School of Basic Medicine and Collaborative 
      Innovation Center for Brain Science, Key Laboratory for Neurological Disorders of 
      the Ministry of Education of China, Tongji Medical College, Huazhong University 
      of Science and Technology, Wuhan, 430030, China.
FAU - Ni, Shaozhou
AU  - Ni S
AD  - Emergency Department, Zhongnan Hospital of Wuhan University, Wuhan, 430071, 
      China.
FAU - Li, Qihang
AU  - Li Q
AD  - School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, 
      Wenzhou, 325000, China.
FAU - Wang, Jian-Zhi
AU  - Wang JZ
AD  - Department of Pathophysiology, School of Basic Medicine and Collaborative 
      Innovation Center for Brain Science, Key Laboratory for Neurological Disorders of 
      the Ministry of Education of China, Tongji Medical College, Huazhong University 
      of Science and Technology, Wuhan, 430030, China. wangjz@mail.hust.edu.cn.
AD  - Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226000, 
      China. wangjz@mail.hust.edu.cn.
FAU - Yang, Ying
AU  - Yang Y
AD  - Department of Pathophysiology, School of Basic Medicine and Collaborative 
      Innovation Center for Brain Science, Key Laboratory for Neurological Disorders of 
      the Ministry of Education of China, Tongji Medical College, Huazhong University 
      of Science and Technology, Wuhan, 430030, China. yingyang@hust.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20180928
PL  - Singapore
TA  - Neurosci Bull
JT  - Neuroscience bulletin
JID - 101256850
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Mapt protein, rat)
RN  - 0 (tau Proteins)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Alzheimer Disease/etiology/metabolism/pathology/*therapy
MH  - Amyloid beta-Peptides/metabolism
MH  - Animals
MH  - Dietary Supplements
MH  - Disease Models, Animal
MH  - Folic Acid/*therapeutic use
MH  - Homocysteine
MH  - Hyperhomocysteinemia/complications/metabolism/pathology/*therapy
MH  - Male
MH  - Rats, Sprague-Dawley
MH  - Retina/metabolism/*pathology
MH  - Retinal Vessels/metabolism/pathology
MH  - Vitamin B 12/*therapeutic use
MH  - tau Proteins/metabolism
PMC - PMC6426902
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Folate
OT  - Hyperhomocysteinemia
OT  - Retina
OT  - Vitamin B12
COIS- The authors declare no competing interests.
EDAT- 2018/09/29 06:00
MHDA- 2019/04/30 06:00
PMCR- 2020/04/01
CRDT- 2018/09/29 06:00
PHST- 2018/04/20 00:00 [received]
PHST- 2018/07/18 00:00 [accepted]
PHST- 2018/09/29 06:00 [pubmed]
PHST- 2019/04/30 06:00 [medline]
PHST- 2018/09/29 06:00 [entrez]
PHST- 2020/04/01 00:00 [pmc-release]
AID - 10.1007/s12264-018-0293-8 [pii]
AID - 293 [pii]
AID - 10.1007/s12264-018-0293-8 [doi]
PST - ppublish
SO  - Neurosci Bull. 2019 Apr;35(2):325-335. doi: 10.1007/s12264-018-0293-8. Epub 2018 
      Sep 28.