PMID- 30264663
OWN - NLM
STAT- MEDLINE
DCOM- 20210330
LR  - 20210330
IS  - 1476-8305 (Electronic)
IS  - 1028-415X (Linking)
VI  - 23
IP  - 7
DP  - 2020 Jul
TI  - Omega-3 fatty acids and anxiety: A systematic review of the possible mechanisms 
      at play.
PG  - 494-504
LID - 10.1080/1028415X.2018.1525092 [doi]
AB  - Introduction: Anxiety is prevalent, costly, and associated with significant 
      adverse outcomes. The importance of nutrition is underestimated in the management 
      of mental health disorders. In particular, omega-3 fatty acids (omega-3 FAs) are a 
      critical component for healthy development and have been shown to reduce anxiety 
      symptoms. Objective: This paper reviews the current state of the research to 
      identify potential mechanisms underlying the relationship between omega-3 FAs and 
      anxiety reduction. Method: Studies were identified using PubMed, PsycINFO, and 
      CINAHL databases. Results: Of the 197 full-text studies screened, six met 
      criteria for inclusion. Four mechanisms were identified based on primary outcomes 
      reported by each study, Inflammatory Response, Brain-Derived Neurotrophic Factor 
      (BDNF), Cortisol, and Cardiovascular Activity. Conclusion: Five key 
      recommendations are provided to guide future research examining omega-3 FAs and 
      anxiety. They include: (1) standardization of dosage and duration of omega-3 
      supplementation, (2) more rigorous measurement of variables, (3) effective 
      blinding of participants, (4) designing experiments that test mediation, and (5) 
      increasing sample diversity.
FAU - Polokowski, Ashley R
AU  - Polokowski AR
AUID- ORCID: 0000-0002-9246-005X
AD  - The Graduate Center, City University of New York, New York, NY, USA.
AD  - Brooklyn College, City University of New York, Brooklyn, NY, USA.
FAU - Shakil, Haque
AU  - Shakil H
AD  - Brooklyn College, City University of New York, Brooklyn, NY, USA.
FAU - Carmichael, Cheryl L
AU  - Carmichael CL
AUID- ORCID: 0000-0002-4474-3485
AD  - The Graduate Center, City University of New York, New York, NY, USA.
AD  - Brooklyn College, City University of New York, Brooklyn, NY, USA.
FAU - Reigada, Laura C
AU  - Reigada LC
AUID- ORCID: 0000-0003-3424-759X
AD  - The Graduate Center, City University of New York, New York, NY, USA.
AD  - Brooklyn College, City University of New York, Brooklyn, NY, USA.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20180928
PL  - England
TA  - Nutr Neurosci
JT  - Nutritional neuroscience
JID - 100892202
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Anxiety/complications/*diet therapy/*physiopathology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Dietary Supplements
MH  - Fatty Acids, Omega-3/*administration & dosage
MH  - Humans
MH  - Hydrocortisone/metabolism
MH  - Inflammation/complications
MH  - Stress, Physiological
OTO - NOTNLM
OT  - Anxiety
OT  - Brain-derived neurotrophic factor
OT  - Inflammation
OT  - Omega-3 fatty acids
EDAT- 2018/09/29 06:00
MHDA- 2021/03/31 06:00
CRDT- 2018/09/29 06:00
PHST- 2018/09/29 06:00 [pubmed]
PHST- 2021/03/31 06:00 [medline]
PHST- 2018/09/29 06:00 [entrez]
AID - 10.1080/1028415X.2018.1525092 [doi]
PST - ppublish
SO  - Nutr Neurosci. 2020 Jul;23(7):494-504. doi: 10.1080/1028415X.2018.1525092. Epub 
      2018 Sep 28.